Collated Gene Ontology terms

Biological process: S-adenosylmethionine-dependent methyltransferase activity(2023) methyltransferase activity(2021, 2022, 2023) rRNA methyltransferase activity(2023) rRNA (adenine-N6,N6-)-dimethyltransferase activity(2023) transferase activity(2023) sequence-specific DNA binding(2023) oxidoreductase activity(2023) DNA-binding transcription factor activity(2023) DNA binding(2023) 2-alkenal reductase [NAD(P)+] activity(2023)

Molecular function: methylation2023 rRNA modification2023 rRNA methylation2023 regulation of DNA-templated transcription2023

Cellular component: membrane2023 striated muscle dense body2012 nucleus2023 cytoplasm2012

Phylogenetic distribution

Chordates: 20/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 6/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 3/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 34/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 0 2 4 6 8 10 Knownness

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
W1NQP7_AMBTC
EnsemblPlants»
0.0
AMTR_s00092p00143460 Methyltransferase domain-containing protein Amborella trichopoda
TI:13333 None
 
A0A803SNG3_ANOCA
Ensembl»
0.0
METTL25B Ribosomal RNA adenine
dimethylase domain containing 1		 Anolis carolinensis
TI:28377 None
   
G1KQ73_ANOCA
Ensembl»
0.0
METTL25 Methyltransferase like 25 Anolis carolinensis
TI:28377 None
   
A0A1S4GT52_ANOGA
EnsemblMetazoa»
0.0
Methyltransferase domain-containing protein Anopheles gambiae
TI:7165 None
 
A0A1S4H5B8_ANOGA
EnsemblMetazoa»
0.0
Methyltransferase domain-containing protein Anopheles gambiae
TI:7165 None
 
Q7QJP7_ANOGA
EnsemblMetazoa»
0.0
1269622 AGAP007607-PA Anopheles gambiae
TI:7165 None
 
A0A1P8AP99_ARATH
TAIR»
0.0
At1g16650 S-adenosyl-L-methionine-dependent methyltransferases
superfamily protein		 Arabidopsis thaliana
TI:3702 None
 
Q4WEG1_ASPFU
EnsemblFungi»
0.0
AFUA_5G02890 Methyltransferase domain-containing protein Aspergillus fumigatus
TI:746128 None 		 
 
E1BDD1_BOVIN
Ensembl»
0.0
METTL25 Methyltransferase like 25 Bos taurus
TI:9913 None
   
F1MN22_BOVIN
Ensembl»
0.0
METTL25B Methyltransferase like 25B Bos taurus
TI:9913 None
   
MT25B_BOVIN
CTD»
0.0
METTL25B Methyltransferase-like protein
25B (Protein RRNAD1)		 Bos taurus
TI:9913 None
 
I1IGK1_BRADI
EnsemblPlants»
0.0
100846767 Methyltransferase domain-containing protein Brachypodium distachyon
TI:15368 None
 
A0A9J7HPE0_BRAFL
CTD»
0.0
LOC118406831 Methyltransferase-like protein 25 Branchiostoma floridae
TI:7739 None
   
A0A9J7ML28_BRAFL
CTD»
0.0
LOC118412741 Methyltransferase-like protein 25 Branchiostoma floridae
TI:7739 None
   
A0A9J7N6N0_BRAFL
CTD»
0.0
LOC118428960 Protein RRNAD1-like Branchiostoma floridae
TI:7739 None 		     
A0A078HCB7_BRANA
EnsemblPlants»
0.0
BnaA06g11190D (rape) hypothetical
protein (BnaA06g11190D protein)		 Brassica napus
TI:3708 None
 
A0A078HQG1_BRANA
EnsemblPlants»
0.0
BnaC05g12730D (rape) hypothetical
protein (BnaC05g12730D protein)		 Brassica napus
TI:3708 None
 
A8WS57_CAEBR
WormBase»
0.0
CBG02258 CBG_02258 Protein CBG02258 Caenorhabditis briggsae
TI:6238 None 		 
 
Q93574_CAEEL
WormBase»
0.0
CELE_F25H2.12 F25H2.12 Methyltransferase domain-containing protein Caenorhabditis elegans
TI:6239 None
 
A0A8I3N2U9_CANLF
Ensembl»
0.0
METTL25B Methyltransferase domain-containing protein Canis lupus
TI:9612 None
   
A0A8I3NER4_CANLF
Ensembl»
0.0
METTL25 Methyltransferase like 25 Canis lupus
TI:9612 None
   
A0A1U8HDV0_CAPAN
EnsemblPlants»
0.0
T459_21066 Methyltransferase domain-containing protein Capsicum annuum
TI:4072 None
 
F6PZV6_CIOIN
Ensembl»
0.0
Methyltransferase domain-containing protein Ciona intestinalis
TI:7719 None
 
A0A067EE87_CITSI
Ensembl»
0.0
CISIN_1g022433mg Methyltransferase domain-containing protein Citrus sinensis
TI:2711 None 		 
   
A0A0A0L857_CUCSA
EnsemblPlants»
0.0
Csa_3G523080 Uncharacterized protein Cucumis sativus
TI:3659 None
   
A0A0A0LB00_CUCSA
EnsemblPlants»
0.0
Csa_3G523070 Methyltransferase domain-containing protein Cucumis sativus
TI:3659 None
 
A0A0R4IL77_DANRE
ZFIN»
0.0
rrnad1 Protein RRNAD1 (Ribosomal RNA
adenine dimethylase domain containing 1)		 Danio rerio
TI:7955 None
 
Q5RGQ0_DANRE
ZFIN»
0.0
si:dkey-21h14.1 Methyltransferase-like 25
(Methyltransferase-like protein 25)		 Danio rerio
TI:7955 None
 
E9FS17_DAPPU
EnsemblMetazoa»
0.0
DAPPUDRAFT_309622 Methyltransferase domain-containing protein Daphnia pulex
TI:6669 None
 
E9FVX3_DAPPU
EnsemblMetazoa»
0.0
DAPPUDRAFT_95488 Methyltransferase domain-containing protein Daphnia pulex
TI:6669 None
 
E9FWR0_DAPPU
EnsemblMetazoa»
0.0
DAPPUDRAFT_96038 Methyltransferase domain-containing protein Daphnia pulex
TI:6669 None 		 
 
Q86K81_DICDI
dictyBase»
0.0
DDB_G0277177 Methyltransferase domain-containing protein Dictyostelium discoideum
TI:44689 None
 
A8DY65_DROME
FlyBase»
0.5
Dmel\CG2906 Uncharacterized protein, isoform D Drosophila melanogaster
TI:7227 None
 
Q86NX3_DROME
FlyBase»
0.5
CG8447 GM20958p Drosophila melanogaster
TI:7227 None
 
Q5AU65_EMENI
EnsemblFungi»
0.0
ANIA_08165 Methyltransferase domain-containing protein Emericella nidulans
TI:162425 None 		 
 
C4LUH0_ENTH1
EnsemblProtists»
0.0
EHI_049710 Methyltransferase domain-containing protein Entamoeba histolytica
TI:5759 None
 
C4LZG4_ENTH1
EnsemblProtists»
0.0
EHI_138040 Methyltransferase domain-containing protein Entamoeba histolytica
TI:5759 None
 
C4MAJ6_ENTH1
EnsemblProtists»
0.0
EHI_160690 Methyltransferase domain-containing protein Entamoeba histolytica
TI:5759 None
 
A0A022QM32_ERYGU
Ensembl»
0.0
MIMGU_mgv1a003870mg Methyltransferase domain-containing protein Erythranthe guttata
TI:4155 None
 
A0A059BP92_EUCGR
EnsemblPlants»
0.0
EUGRSUZ_F01450 Methyltransferase domain-containing protein Eucalyptus grandis
TI:71139 None
 
M3WIR5_FELCA
Ensembl»
0.0
METTL25 Methyltransferase like 25 Felis catus
TI:9685 None
 
M3X477_FELCA
Ensembl»
0.0
METTL25B Methyltransferase like 25B Felis catus
TI:9685 None
 
A0A8V0Y5K3_CHICK
Ensembl»
0.0
METTL25 Methyltransferase like 25 Gallus gallus
TI:9031 None
   
A0A8V1A3Q1_CHICK
Ensembl»
0.0
RRNAD1 Methyltransferase like 25B Gallus gallus
TI:9031 None
   
A0A644F669_GIAIC
EnsemblProtists»
0.0
GL50803_005272 Methyltransferase domain-containing protein Giardia intestinalis
TI:5741 None
 
K7L7A1_SOYBN
EnsemblPlants»
0.0
100815120 Methyltransferase domain-containing protein Glycine max
TI:3847 None
 
A0A2I2YC73_GORGO
Ensembl»
0.0
METTL25B Ribosomal RNA adenine
dimethylase domain containing 1		 Gorilla gorilla
TI:9593 None
 
G3SGS5_GORGO
Ensembl»
0.0
METTL25 Methyltransferase like 25 Gorilla gorilla
TI:9593 None
 
A0A1U8JUZ8_GOSHI
Ensembl»
0.0
LOC107909161 Protein RRNAD1-like isoform X1 Gossypium hirsutum
TI:3635 None
   
A0A1U8LKI5_GOSHI
Ensembl»
0.0
LOC107928400 Protein RRNAD1-like isoform X1 Gossypium hirsutum
TI:3635 None
   
A0A251UU99_HELAN
EnsemblPlants»
0.0
HannXRQ_Chr05g0160631 HanXRQr2_Chr05g0234991 Methyltransferase domain-containing protein (Putative
S-adenosyl-L-methionine-dependent methyltransferases superfamily protein)		 Helianthus annuus
TI:4232 None
 
T1ENR3_HELRO
EnsemblMetazoa»
0.0
20198213 Methyltransferase domain-containing protein Helobdella robusta
TI:6412 None
 
T1FY66_HELRO
EnsemblMetazoa»
0.0
20213764 Methyltransferase domain-containing protein Helobdella robusta
TI:6412 None 		 
 
MET25_HUMAN
Ensembl»
0.0
METTL25 Probable methyltransferase-like protein
25 (EC 2.1.1.-)		 Homo sapiens
TI:9606 None
 
MT25B_HUMAN
Ensembl»
0.0
METTL25B Methyltransferase-like protein 25B (Protein RRNAD1) (Ribosomal
RNA adenine dimethylase domain-containing protein 1)		 Homo sapiens
TI:9606 None
 
A0A8I6YN74_HORVV
EnsemblPlants»
0.0
Methyltransferase domain-containing protein Hordeum vulgare
TI:4513 None
   
B7PN77_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW005962 Myosin heavy chain, putative (EC 1.3.1.74) Ixodes scapularis
TI:6945 None
 
B7PV43_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW007652 Methyltransferase domain-containing protein Ixodes scapularis
TI:6945 None
 
B7PWI6_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW019274 Uncharacterized protein Ixodes scapularis
TI:6945 None 		 
   
A0A6P9E741_JUGRE
EnsemblPlants»
0.0
LOC108995674 Protein RRNAD1 isoform X1 Juglans regia
TI:51240 None
   
A0A1Y1IBG0_KLENI
EnsemblPlants»
0.0
KFL_002670060 S-adenosyl-L-methionine-dependent methyltransferases
superfamily protein		 Klebsormidium nitens
TI:105231 None
 
Q4QE60_LEIMA
EnsemblProtists»
0.0
LMJF_17_1310 Methyltransferase domain-containing protein Leishmania major
TI:5664 None 		 
 
W5MN45_LEPOC
Ensembl»
0.0
Ribosomal RNA adenine
dimethylase domain containing 1		 Lepisosteus oculatus
TI:7918 None
 
W5NHP7_LEPOC
Ensembl»
0.0
Methyltransferase like 25 Lepisosteus oculatus
TI:7918 None
 
F6UBC5_MACMU
Ensembl»
0.0
METTL25B Methyltransferase like 25B
(Protein RRNAD1 isoform 1)		 Macaca mulatta
TI:9544 None
 
F7HEH7_MACMU
Ensembl»
0.0
METTL25 Methyltransferase like 25 Macaca mulatta
TI:9544 None
   
A0A2C9W5N6_MANES
EnsemblPlants»
0.0
MANES_03G082700 Methyltransferase domain-containing protein Manihot esculenta
TI:3983 None
 
G7IGY2_MEDTR
EnsemblPlants»
0.0
11424717 Methyltransferase-like protein
(Putative S-adenosyl-L-methionine-dependent methyltransferase)		 Medicago truncatula
TI:3880 None
 
F7F5G2_MONDO
Ensembl»
0.0
METTL25 Methyltransferase like 25 Monodelphis domestica
TI:13616 None
   
F7FVV1_MONDO
Ensembl»
0.0
METTL25B Ribosomal RNA adenine
dimethylase domain containing 1		 Monodelphis domestica
TI:13616 None
   
A9UVZ7_MONBE
EnsemblProtists»
0.0
MONBRDRAFT_31878 Fork-head domain-containing protein Monosiga brevicollis
TI:81824 None
 
MET25_MOUSE
AG»
0.0
Mettl25 Probable methyltransferase-like protein
25 (EC 2.1.1.-)		 Mus musculus
TI:10090 None
 
MT25B_MOUSE
Ensembl»
0.0
Mettl25b Methyltransferase-like protein
25B (Protein RRNAD1)		 Mus musculus
TI:10090 None
 
A0A804I2Z6_MUSAM
EnsemblPlants»
0.0
Methyltransferase domain-containing protein Musa acuminata
TI:4641 None
   
A0A1U7ZW38_NELNU
EnsemblBacteria»
0.0
LOC104598351 Protein RRNAD1 isoform X1 Nelumbo nucifera
TI:4432 None
   
A7RHS3_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g197305 Methyltransferase domain-containing protein Nematostella vectensis
TI:45351 None
 
A7SXF1_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g218997 Methyltransferase domain-containing protein Nematostella vectensis
TI:45351 None 		 
   
A7SXF2_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g218998 Methyltransferase domain-containing protein Nematostella vectensis
TI:45351 None 		 
 
A7SXF3_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g218999 Uncharacterized protein Nematostella vectensis
TI:45351 None
   
Q7S2C1_NEUCR
EnsemblFungi»
0.0
NCU09540 Methyltransferase domain-containing protein Neurospora crassa
TI:5141 None 		 
 
A0A1S3Y454_TOBAC
EnsemblFungi»
0.0
LOC107772045 Methyltransferase-like protein 25 isoform X1 Nicotiana tabacum
TI:4097 None
   
A0A1S3YN09_TOBAC
EnsemblFungi»
0.0
LOC107777989 Protein RRNAD1-like isoform X1 Nicotiana tabacum
TI:4097 None
   
A0A6I8PEA8_ORNAN
Ensembl»
0.0
METTL25B Ribosomal RNA adenine
dimethylase domain containing 1		 Ornithorhynchus anatinus
TI:9258 None
   
F7DKA2_ORNAN
Ensembl»
0.0
Methyltransferase domain-containing protein Ornithorhynchus anatinus
TI:9258 None
   
Q2QMB6_ORYSJ
EnsemblPlants»
0.0
LOC_Os12g41670 Os12g0610500 Expressed protein (Os12g0610500 protein) Oryza sativa
TI:4530 None
 
H2MIW8_ORYLA
Ensembl»
0.0
mettl25 Methyltransferase like 25 Oryzias latipes
TI:8090 None
   
A0A2I3RRF6_PANTR
Ensembl»
0.0
METTL25B Methyltransferase like 25B Pan troglodytes
TI:9598 None
 
H2Q6J7_PANTR
Ensembl»
0.0
METTL25 Chromosome 12 open reading
frame 26 (Methyltransferase like 25)		 Pan troglodytes
TI:9598 None
 
Q0TYD2_PHANO
EnsemblFungi»
0.0
SNOG_15464 Methyltransferase domain-containing protein Phaeosphaeria nodorum
TI:13684 None 		 
 
A0A2K1JHB3_PHYPA
EnsemblPlants»
0.0
PHYPA_018089 Methyltransferase domain-containing protein Physcomitrium patens
TI:3218 None
 
A0A2K1L945_PHYPA
EnsemblPlants»
0.0
PHYPA_000967 Methyltransferase domain-containing protein Physcomitrium patens
TI:3218 None
 
B9HH14_POPTR
EnsemblPlants»
0.0
POPTR_007G065300 Methyltransferase domain-containing protein Populus trichocarpa
TI:3694 None
 
A0A8R1V2C7_PRIPA
EnsemblMetazoa»
0.0
WBGene00304549 Methyltransferase domain-containing protein Pristionchus pacificus
TI:54126 None
   
A0A251PLZ0_PRUPE
EnsemblPlants»
0.0
PRUPE_4G143400 Methyltransferase domain-containing protein Prunus persica
TI:3760 None 		 
 
A0A8I6GC39_RAT
RGD»
0.0
Mettl25 Methyltransferase like 25 Rattus norvegicus
TI:10116 None
   
MT25B_RAT
RGD»
0.0
Mettl25b Methyltransferase-like protein
25B (Protein RRNAD1)		 Rattus norvegicus
TI:10116 None
 
B9SVD6_RICCO
EnsemblBacteria»
0.0
RCOM_0565640 Methyltransferase domain-containing protein Ricinus communis
TI:3988 None
 
A7E945_SCLS1
EnsemblFungi»
0.0
SS1G_01825 Methyltransferase domain-containing protein Sclerotinia sclerotiorum
TI:5180 None 		 
 
D8RTL1_SELML
EnsemblPlants»
0.0
SELMODRAFT_101072 Methyltransferase domain-containing protein Selaginella moellendorffii
TI:88036 None
 
D8T5K1_SELML
EnsemblPlants»
0.0
SELMODRAFT_429256 Methyltransferase domain-containing protein Selaginella moellendorffii
TI:88036 None 		 
 
D8T5K4_SELML
EnsemblPlants»
0.0
SELMODRAFT_132321 Methyltransferase domain-containing protein Selaginella moellendorffii
TI:88036 None
 
K3Y3H4_SETIT
EnsemblPlants»
0.0
Methyltransferase domain-containing protein Setaria italica
TI:4555 None
 
K3Z543_SETIT
EnsemblPlants»
0.0
101784830 Methyltransferase domain-containing protein Setaria italica
TI:4555 None
 
A0A3Q7HIS7_SOLLC
EnsemblPlants»
0.0
Methyltransferase domain-containing protein Solanum lycopersicum
TI:4081 None
   
M1C026_SOLTU
EnsemblPlants»
0.0
102585032 Methyltransferase domain-containing protein Solanum tuberosum
TI:4113 None
   
C5YRU7_SORBI
EnsemblPlants»
0.0
SORBI_3008G164600 Methyltransferase domain-containing protein Sorghum bicolor
TI:4558 None
 
A0A7M7N849_STRPU
EnsemblMetazoa»
0.0
Methyltransferase domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7NZJ0_STRPU
EnsemblMetazoa»
0.0
Methyltransferase domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A287AWU4_PIG
Ensembl»
0.0
METTL25B Methyltransferase like 25B Sus scrofa
TI:9823 None
   
A0A480U521_PIG
Ensembl»
0.0
METTL25 Methyltransferase like 25 (Methyltransferase-like protein 25
isoform 1) (Methyltransferase-like protein 25 isoform X3)		 Sus scrofa
TI:9823 None
 
A0A061FH79_THECC
EnsemblPlants»
0.0
TCM_032475 S-adenosyl-L-methionine-dependent methyltransferases superfamily
protein, putative isoform 1		 Theobroma cacao
TI:3641 None
 
A0A139WMX3_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_32221 Protein RRNAD1-like Protein Tribolium castaneum
TI:7070 None
 
D6W7X6_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_04755 Protein RRNAD1-like Protein Tribolium castaneum
TI:7070 None 		 
 
B3S7W8_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_60323 Methyltransferase domain-containing protein Trichoplax adhaerens
TI:10228 None
 
A0A3B6KCJ6_WHEAT
EnsemblPlants»
0.0
Methyltransferase domain-containing protein Triticum aestivum
TI:4565 None
   
A0A3B6LGJ0_WHEAT
EnsemblPlants»
0.0
Methyltransferase domain-containing protein Triticum aestivum
TI:4565 None
   
A0A3B6MM84_WHEAT
EnsemblPlants»
0.0
CFC21_075994 Methyltransferase domain-containing protein Triticum aestivum
TI:4565 None
 
Q57ZT6_TRYB2
VEuPathDB»
0.0
Tb05.26K5.970 Methyltransferase domain-containing protein Trypanosoma brucei
TI:5691 None 		 
 
D7SX07_VITVI
EnsemblPlants»
0.0
VIT_19s0027g00240 Methyltransferase domain-containing protein Vitis vinifera
TI:29760 None
 
F6H4V6_VITVI
EnsemblPlants»
0.0
VIT_19s0027g00300 Uncharacterized protein Vitis vinifera
TI:29760 None 		 
   
F6XA78_XENTR
Xenbase»
0.0
mettl25 Methyltransferase-like 25 (Methyltransferase-like
protein 25 isoform X1)		 Xenopus tropicalis
TI:8364 None
   
Q28C31_XENTR
Xenbase»
0.0
mettl25b Novel protein (Protein RRNAD1) Xenopus tropicalis
TI:8364 None
 
A0A1D6MWB7_MAIZE
EnsemblPlants»
0.0
100216669 S-adenosyl-L-methionine-dependent methyltransferase
superfamily protein		 Zea mays
TI:4577 None