Collated Gene Ontology terms

Biological process: iron-sulfur cluster binding(2009, 2011, 2025) metal ion binding(2025) 4 iron, 4 sulfur cluster binding(2025) lamin binding(2007, 2018, 2025) ferredoxin hydrogenase activity(2005, 2025) iron ion binding(2025) oxidoreductase activity(2025) 2 iron, 2 sulfur cluster binding(2025) NADH dehydrogenase (ubiquinone) activity(2025) iron-sulfur cluster chaperone activity(2025)
hydrogenase activity (NAD+, ferredoxin)2025 electron transfer activity2025

Molecular function: iron-sulfur cluster assembly2009, 2011, 2013, 2024, 2025 response to hypoxia2007, 2025 regulation of gene expression2016, 2025 intracellular oxygen homeostasis2007, 2025 regulation of angiogenesis2022, 2025 proton transmembrane transport2025 ATP synthesis coupled electron transport2025 hematopoietic progenitor cell differentiation2014 vesicle-mediated transport2025 sprouting angiogenesis2017
response to oxygen levels2013 endoplasmic reticulum to Golgi vesicle-mediated transport2025 [4Fe-4S] cluster assembly2025

Cellular component: cytosolic [4Fe-4S] assembly targeting complex2012, 2018, 2025 cytosol2009, 2012, 2013, 2018, 2025 nucleus2009, 2013, 2018, 2025 lamin filament2007, 2018, 2025 nuclear lumen2007, 2017, 2025 nucleoplasm2024, 2025 nucleolus2024, 2025 cytoplasm2017, 2024, 2025 membrane2013, 2025 ciliary plasm2017
perinuclear region of cytoplasm2025 nuclear lamina2003

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 15/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 4/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 38/39 
Archea: 0/8 
Bacteria: 6/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
CIAO3_HUMAN
Ensembl»
4.6
CIAO3 Cytosolic iron-sulfur assembly component 3 (Cytosolic Fe-S cluster assembly factor NARFL) (Iron-only hydrogenase-like
protein 1) (IOP1) (Nuclear prelamin A recognition factor-like protein) (Protein related to Narf)		 Homo sapiens
TI:9606 None
 
NARF_HUMAN
Ensembl»
1.3
NARF Nuclear prelamin A recognition factor
(Iron-only hydrogenase-like protein 2) (IOP2)		 Homo sapiens
TI:9606 None
 
NAR1_ARATH
TAIR»
0.8
NAR1 Protein NAR1 (Nuclear architecture related 1) (Protein GROWTH
AT DIFFERENT OXYGEN LEVELS INFLUENCES MORPHOGENESIS) ([FeFe]-hydrogenase-like protein GOLLUM)		 Arabidopsis thaliana
TI:3702 None
 
CIAO3_MOUSE
Ensembl»
4.1
Ciao3 Cytosolic iron-sulfur assembly component 3 (Cytosolic Fe-S cluster assembly factor NARFL)
(Iron-only hydrogenase-like protein 1) (IOP1) (Nuclear prelamin A recognition factor-like protein)		 Mus musculus
TI:10090 None
 
NAR1_YEAST
SGD»
1.6
NAR1 Cytosolic Fe-S cluster assembly factor
NAR1 (Nuclear architecture-related protein 1)		 Saccharomyces cerevisiae
TI:4932 None
 
NARF_DROME
FlyBase»
1.7
CG17683 Probable cytosolic Fe-S
cluster assembly factor CG17683		 Drosophila melanogaster
TI:7227 None
 
NARF_MOUSE
Ensembl»
1.0
Narf Nuclear prelamin A recognition factor
(Iron-only hydrogenase-like protein 2) (IOP2)		 Mus musculus
TI:10090 None
 
CIAO3_RAT
RGD»
3.0
Ciao3 Cytosolic iron-sulfur assembly component 3 (Cytosolic Fe-S cluster assembly factor NARFL)
(Iron-only hydrogenase-like protein 1) (IOP1) (Nuclear prelamin A recognition factor-like protein)		 Rattus norvegicus
TI:10116 None
 
NAR1_SCHPO
PomBase»
1.5
SPCC1450.10c Cytosolic Fe-S cluster assembly factor NAR1
homolog (Nuclear architecture-related protein 1 homolog)		 Schizosaccharomyces pombe
TI:4896 None
 
NARFL_DANRE
ZFIN»
2.1
narfl Cytosolic Fe-S cluster assembly factor narfl
(Nuclear prelamin A recognition factor-like protein)		 Danio rerio
TI:7955 None
 
NARF_CAEEL
WormBase»
0.5
oxy-4 Probable cytosolic Fe-S
cluster assembly factor oxy-4		 Caenorhabditis elegans
TI:6239 None
 
NARF_DANRE
ZFIN»
0.5
narf Nuclear prelamin A recognition factor Danio rerio
TI:7955 None
 
NARF_DICDI
dictyBase»
0.0
narfl Probable cytosolic Fe-S
cluster assembly factor narfl		 Dictyostelium discoideum
TI:44689 None
 
NARF_RAT
RGD»
1.0
Narf Nuclear prelamin A recognition factor
(Iron-only hydrogenase-like protein 2) (IOP2)		 Rattus norvegicus
TI:10116 None
 
A0A8V0Z7C1_CHICK
Ensembl»
0.0
NARFL Nuclear prelamin A
recognition factor-like protein		 Gallus gallus
TI:9031 None
   
E1BYV6_CHICK
Ensembl»
0.0
NARF Nuclear prelamin A recognition
factor (Iron-only hydrogenase-like protein 2)		 Gallus gallus
TI:9031 None