Collated Gene Ontology terms

Biological process: protein methyltransferase activity(2024, 2025) methyltransferase activity(2025) protein-lysine N-methyltransferase activity(2020, 2025) transferase activity(2025) heat shock protein binding(2017, 2025)

Molecular function: methylation2025 protein methylation2017, 2025 hematopoietic stem cell differentiation2017

Cellular component: nucleus2017, 2018, 2020, 2022, 2025 protein-containing complex2017, 2025 nucleoplasm2016, 2024, 2025 nucleolus2024, 2025 cytoplasm2018, 2022

Phylogenetic distribution

Chordates: 20/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 1/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 1/4 
Hacrobia: 0/0 
Plants: 38/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
MET22_HUMAN
Ensembl»
4.7
METTL22 Methyltransferase-like protein 22 (EC 2.1.1.-) Homo sapiens
TI:9606 None
 
MET22_MOUSE
Ensembl»
2.0
Mettl22 Methyltransferase-like protein 22 (EC 2.1.1.-) Mus musculus
TI:10090 None
 
D3Z9R2_RAT
RGD»
2.0
Mettl22 Methyltransferase 22, Kin17 lysine Rattus norvegicus
TI:10116 None
   
A0A8V0Z7S4_CHICK
Ensembl»
0.5
METTL22 Methyltransferase-like protein 22 Gallus gallus
TI:9031 None
   
A0A8W4FMY7_PIG
Ensembl»
0.0
METTL22 Methyltransferase-like protein 22 Sus scrofa
TI:9823 None
   
A0A9L0TR24_HORSE
Ensembl»
0.0
METTL22 Methyltransferase-like protein 22 Equus caballus
TI:9796 None
   
F6VLF6_ORNAN
Ensembl»
0.0
METTL22 Methyltransferase-like protein 22 Ornithorhynchus anatinus
TI:9258 None
   
G3R9T0_GORGO
Ensembl»
0.0
METTL22 Methyltransferase-like protein 22 Gorilla gorilla
TI:9593 None
 
G7NPL3_MACMU
Ensembl»
0.0
METTL22 Methyltransferase-like protein 22 Macaca mulatta
TI:9544 None
 
H2RAD8_PANTR
Ensembl»
0.0
METTL22 Methyltransferase-like protein 22 Pan troglodytes
TI:9598 None
 
H9GC35_ANOCA
Ensembl»
0.0
METTL22 Methyltransferase-like protein 22 Anolis carolinensis
TI:28377 None
   
A0A1L8EXE4_XENLA
Xenbase»
0.0
mettl22.L Methyltransferase-like protein 22 isoform X1 Xenopus laevis
TI:8355 None
   
A0A1U8NY88_GOSHI
euHCVdb»
0.0
LOC107953192 Protein N-lysine methyltransferase METTL21A Gossypium hirsutum
TI:3635 None
   
A0A251T5H5_HELAN
euHCVdb»
0.0
HannXRQ_Chr12g0380421 Putative methyltransferase family protein Helianthus annuus
TI:4232 None
 
A0A251VDP1_HELAN
euHCVdb»
0.0
HannXRQ_Chr02g0032801 HanXRQr2_Chr02g0047591 Lysine methyltransferase, S-adenosyl-L-methionine-dependent methyltransferase
(Putative methyltransferase family protein)		 Helianthus annuus
TI:4232 None
 
B3DIQ7_DANRE
ZFIN»
1.3
mettl22 Methyltransferase 22, Kin17 lysine
(Methyltransferase-like protein 22) (Zgc:194177 protein)		 Danio rerio
TI:7955 None
 
F4HQD3_ARATH
TAIR»
0.5
At1g79915 Methyltransferase family protein Arabidopsis thaliana
TI:3702 None
 
F4IVK3_ARATH
TAIR»
0.5
At2g26810 Methyltransferase family protein Arabidopsis thaliana
TI:3702 None
 
G7II38_MEDTR
EnsemblPlants»
0.0
11436359 Methyltransferase family protein (Putative
lysine methyltransferase, S-adenosyl-L-methionine-dependent methyltransferase)		 Medicago truncatula
TI:3880 None
 
A0A061GCA1_THECC
euHCVdb»
0.0
TCM_028730 Methyltransferase family protein, putative Theobroma cacao
TI:3641 None
 
A0A061GZD7_THECC
euHCVdb»
0.0
TCM_040875 Methyltransferase family protein isoform 3 Theobroma cacao
TI:3641 None
 
A0A1U8B7C0_NELNU
euHCVdb»
0.0
LOC104607808 Protein N-lysine methyltransferase METTL21A Nelumbo nucifera
TI:4432 None
   
A0A2I4G263_JUGRE
euHCVdb»
0.0
LOC109004044 Protein N-lysine methyltransferase METTL21A Juglans regia
TI:51240 None
   
A0A3B3I3L3_ORYLA
Ensembl»
0.0
METTL22 Methyltransferase 22, Kin17 lysine Oryzias latipes
TI:8090 None
   
A0A8I3NUW4_CANLF
Ensembl»
0.0
METTL22 Methyltransferase-like protein 22 Canis lupus
TI:9612 None
   
A0A9J7KKJ4_BRAFL
neXtProt»
0.0
LOC118407204 Methyltransferase-like protein 22 Branchiostoma floridae
TI:7739 None
   
A0A9K3MX42_HELAN
neXtProt»
0.0
HanXRQr2_Chr12g0554521 Lysine methyltransferase,
S-adenosyl-L-methionine-dependent methyltransferase		 Helianthus annuus
TI:4232 None
 
D6WHD5_TRICA
CTD»
0.0
AUGUSTUS-3.0.2_02921 Methyltransferase-like protein 22 Tribolium castaneum
TI:7070 None
 
F6XFW3_MONDO
Ensembl»
0.0
METTL22 Methyltransferase-like protein 22 Monodelphis domestica
TI:13616 None
   
W5MI07_LEPOC
Ensembl»
0.0
Methyltransferase 22, Kin17 lysine Lepisosteus oculatus
TI:7918 None
 
A0A1S4B9A6_TOBAC
euHCVdb»
0.0
LOC107805892 Uncharacterized protein LOC107805892 Nicotiana tabacum
TI:4097 None
   
A0A1U8I1D9_GOSHI
euHCVdb»
0.0
LOC107891703 Methyltransferase-like protein 22 Gossypium hirsutum
TI:3635 None
   
A0A1U8P2I0_GOSHI
euHCVdb»
0.0
LOC107954314 Protein N-lysine methyltransferase
METTL21A isoform X1		 Gossypium hirsutum
TI:3635 None
   
A0A9R0ICL0_SPIOL
euHCVdb»
0.0
LOC110786610 Uncharacterized protein isoform X1 Spinacia oleracea
TI:3562 None
   
A0EGI8_PARTE
euHCVdb»
0.0
GSPATT00026753001 Calmodulin-lysine N-methyltransferase Paramecium tetraurelia
TI:5888 None
 
Q9VP86_DROME
FlyBase»
1.0
anon-WO0118547.713 IP09210p Drosophila melanogaster
TI:7227 None
 
A0A022Q0K2_ERYGU
euHCVdb»
0.0
MIMGU_mgv1a018716mg Methyltransferase-like protein 22 Erythranthe guttata
TI:4155 None
 
A0A067E7T9_CITSI
neXtProt»
0.0
CISIN_1g019839mg Methyltransferase-like protein 22 Citrus sinensis
TI:2711 None
 
A0A067EU60_CITSI
euHCVdb»
0.0
CISIN_1g030274mg Methyltransferase small
domain-containing protein		 Citrus sinensis
TI:2711 None
 
A0A072UWU7_MEDTR
EnsemblPlants»
0.0
MTR_3g045720 Methyltransferase family protein, putative Medicago truncatula
TI:3880 None
 
A0A0A0KI86_CUCSA
euHCVdb»
0.0
Csa_6G429120 Uncharacterized protein Cucumis sativus
TI:3659 None
 
A0A0K9PS00_ZOSMR
euHCVdb»
0.0
ZOSMA_18G01130 Protein N-lysine methyltransferase METTL21A Zostera marina
TI:29655 None
 
A0A0P0WZ67_ORYSJ
neXtProt»
0.0
Os06g0639300 Os06g0639300 protein Oryza sativa
TI:4530 None
 
A0A0Q3JAQ8_BRADI
EnsemblPlants»
0.0
BRADI_1g19870v3 Uncharacterized protein Brachypodium distachyon
TI:15368 None
 
A0A0Q3JFL1_BRADI
EnsemblPlants»
0.0
LOC100831791 Methyltransferase-like protein 22 Brachypodium distachyon
TI:15368 None
 
A0A0R0IWS7_SOYBN
EnsemblPlants»
0.0
GLYMA_08G154800 Methyltransferase small
domain-containing protein		 Glycine max
TI:3847 None
 
A0A194YLI2_SORBI
neXtProt»
0.0
SORBI_3010G202900 Methyltransferase-like protein 22 Sorghum bicolor
TI:4558 None
 
A0A1S4H7S5_ANOGA
EnsemblMetazoa»
0.0
Uncharacterized protein Anopheles gambiae
TI:7165 None
 
A0A1U7ZAT9_NELNU
euHCVdb»
0.0
LOC104592229 Methyltransferase-like protein 22 isoform X1 Nelumbo nucifera
TI:4432 None
   
A0A1Y1HLW6_KLENI
neXtProt»
0.0
KFL_000340280 Methyltransferase family protein Klebsormidium nitens
TI:105231 None
 
A0A1Y1HQB0_KLENI
neXtProt»
0.0
KFL_000630130 Uncharacterized protein Klebsormidium nitens
TI:105231 None
 
A0A251PWJ4_PRUPE
euHCVdb»
0.0
PRUPE_3G070300 Methyltransferase-like protein 22 Prunus persica
TI:3760 None
 
A0A2C9UZY4_MANES
neXtProt»
0.0
MANES_11G045900v8 Methyltransferase-like protein 22 Manihot esculenta
TI:3983 None
 
A0A2G2YFQ1_CAPAN
euHCVdb»
0.0
T459_28026 Uncharacterized protein Capsicum annuum
TI:4072 None
 
A0A2G3A3E3_CAPAN
euHCVdb»
0.0
T459_10870 Methyltransferase-like protein 22 Capsicum annuum
TI:4072 None
 
A0A2I4GAC9_JUGRE
euHCVdb»
0.0
LOC109006110 Methyltransferase-like protein 22 Juglans regia
TI:51240 None
   
A0A2K1J7Q7_PHYPA
EnsemblPlants»
0.0
LOC112293367 Methyltransferase-like protein 22 Physcomitrium patens
TI:3218 None
 
A0A2K1KT74_PHYPA
EnsemblPlants»
0.0
LOC112280054 Uncharacterized protein Physcomitrium patens
TI:3218 None
 
A0A2K1Z415_POPTR
neXtProt»
0.0
POPTR_009G068400 Methyltransferase family protein Populus trichocarpa
TI:3694 None
 
A0A2K3E5X4_CHLRE
euHCVdb»
0.0
CHLRE_01g019051v5 Uncharacterized protein Chlamydomonas reinhardtii
TI:3055 None
 
A0A2R6WN10_MARPO
euHCVdb»
0.0
MARPO_0072s0004 Methyltransferase-like protein 22 Marchantia polymorpha
TI:3197 None
 
A0A2R6XW22_MARPO
euHCVdb»
0.0
MARPO_0001s0305 Calmodulin-lysine N-methyltransferase Marchantia polymorpha
TI:3197 None
 
A0A2X0S2A5_WHEAT
EnsemblPlants»
0.0
LOC123051895 Uncharacterized protein Triticum aestivum
TI:4565 None
   
A0A3B6AUY6_WHEAT
EnsemblPlants»
0.0
LOC123187776 Protein N-lysine methyltransferase METTL21A Triticum aestivum
TI:4565 None
   
A0A3B6C1Q6_WHEAT
EnsemblPlants»
0.0
LOC123044019 Protein N-lysine methyltransferase METTL21A Triticum aestivum
TI:4565 None
   
A0A3B6RS33_WHEAT
EnsemblPlants»
0.0
Methyltransferase-like protein 22 Triticum aestivum
TI:4565 None
   
A0A3B6SKP6_WHEAT
EnsemblPlants»
0.0
LOC123157363 Methyltransferase-like protein 22 Triticum aestivum
TI:4565 None
   
A0A3B6TMB5_WHEAT
EnsemblPlants»
0.0
LOC123166264 Methyltransferase-like protein 22 Triticum aestivum
TI:4565 None
   
A0A3Q7FVC3_SOLLC
EnsemblPlants»
0.0
LOC101251073 Methyltransferase-like protein 22 Solanum lycopersicum
TI:4081 None
   
A0A3Q7IYQ6_SOLLC
EnsemblPlants»
0.0
Uncharacterized protein Solanum lycopersicum
TI:4081 None
   
A0A7M7GQ05_STRPU
EnsemblMetazoa»
0.0
Methyltransferase-like protein 22 Strongylocentrotus purpuratus
TI:7668 None
   
A0A804IP36_MUSAM
EnsemblPlants»
0.0
GSMUA_118030.1 (wild Malaysian banana) hypothetical protein Musa acuminata
TI:4641 None
 
A0A804K3A9_MUSAM
EnsemblPlants»
0.0
Calmodulin-lysine N-methyltransferase Musa acuminata
TI:4641 None
   
A0A804PVE8_MAIZE
EnsemblPlants»
0.0
LOC100217263 Methyltransferase family protein Zea mays
TI:4577 None
   
A0A9R1WIP1_LACSA
euHCVdb»
0.0
LSAT_V11C100014600 Methyltransferase-like protein 22 Lactuca sativa
TI:4236 None
 
A0ABI7WR89_FELCA
Ensembl»
0.0
METTL22 Methyltransferase like 22 Felis catus
TI:9685 None
   
A9UXY8_MONBE
euHCVdb»
0.0
MONBRDRAFT_7669 Uncharacterized protein Monosiga brevicollis
TI:81824 None
 
B3RMS0_TRIAD
CTD»
0.0
TRIADDRAFT_20455 Methyltransferase-like protein 22 Trichoplax adhaerens
TI:10228 None
 
B3RMS2_TRIAD
CTD»
0.0
TRIADDRAFT_21429 Methyltransferase-like protein 22 Trichoplax adhaerens
TI:10228 None
 
B7Q9F2_IXOSC
EnsemblMetazoa»
0.0
8037870 Methyltransferase-like protein 22 Ixodes scapularis
TI:6945 None
 
B9GFN7_POPTR
euHCVdb»
0.0
POPTR_001G181200 Methyltransferase family protein Populus trichocarpa
TI:3694 None
 
B9RQQ2_RICCO
euHCVdb»
0.0
RCOM_1494750 Methyltransferase-like protein 22 Ricinus communis
TI:3988 None
 
D7T199_VITVI
euHCVdb»
0.0
VIT_06s0009g02660 Protein N-lysine methyltransferase METTL21A Vitis vinifera
TI:29760 None
 
D7U0K3_VITVI
euHCVdb»
0.0
VIT_09s0002g04570 Methyltransferase-like protein 22 Vitis vinifera
TI:29760 None
 
D8SP32_SELML
euHCVdb»
0.0
SELMODRAFT_446149 Uncharacterized protein Selaginella moellendorffii
TI:88036 None
 
E9H382_DAPPU
neXtProt»
0.0
DAPPUDRAFT_231335 Methyltransferase-like protein 22 Daphnia pulex
TI:6669 None
 
F1ML61_BOVIN
Ensembl»
0.0
METTL22 Methyltransferase 22, Kin17 lysine Bos taurus
TI:9913 None
   
F2E3I4_HORVV
EnsemblPlants»
0.0
Predicted protein Hordeum vulgare
TI:4513 None
 
I1MCP1_SOYBN
EnsemblPlants»
0.0
LOC100306070 Methyltransferase-like protein 22 Glycine max
TI:3847 None
 
K3Y3J0_SETIT
EnsemblPlants»
0.0
LOC101768665 Methyltransferase-like protein 22 Setaria italica
TI:4555 None
 
K3ZWA6_SETIT
EnsemblPlants»
0.0
Protein N-lysine methyltransferase METTL21A Setaria italica
TI:4555 None
 
M0VN53_HORVV
EnsemblPlants»
0.0
Methyltransferase-like protein 22 Hordeum vulgare
TI:4513 None
   
M1A4D8_SOLTU
EnsemblPlants»
0.0
LOC102588965 Methyltransferase family protein Solanum tuberosum
TI:4113 None
   
M1D381_SOLTU
EnsemblPlants»
0.0
Protein N-lysine methyltransferase METTL21A Solanum tuberosum
TI:4113 None
   
M4C8K5_BRACM
EnsemblPlants»
0.0
Uncharacterized protein Brassica campestris
TI:3711 None
   
Q7XHY7_ORYSJ
euHCVdb»
0.0
Os07g0641600 Os07g0641600 protein (cDNA clone:J013152N07, full insert
sequence) (cDNA clone:J033066O20, full insert sequence)		 Oryza sativa
TI:4530 None
 
T1EVC7_HELRO
EnsemblMetazoa»
0.0
20200527 Methyltransferase small
domain-containing protein		 Helobdella robusta
TI:6412 None
 
W1NQD5_AMBTC
euHCVdb»
0.0
AMTR_s00101p00152470 FAM86 N-terminal domain-containing protein Amborella trichopoda
TI:13333 None
 
W1Q105_AMBTC
euHCVdb»
0.0
AMTR_s00021p00171430 Methyltransferase-like protein 22 Amborella trichopoda
TI:13333 None
 
A0ABM2YRD7_GOSHI
neXtProt»
0.0
LOC107890042 LOW QUALITY PROTEIN:
methyltransferase-like protein 22		 Gossypium hirsutum
TI:3635 None
   
A0ABM3QID7_SPIOL
euHCVdb»
0.0
LOC110783240 Protein N-lysine methyltransferase METTL21A Spinacia oleracea
TI:3562 None
   
A0A022R7L0_ERYGU
euHCVdb»
0.0
MIMGU_mgv1a016462mg Calmodulin-lysine N-methyltransferase Erythranthe guttata
TI:4155 None
 
A0A0A0KEY7_CUCSA
neXtProt»
0.0
Csa_6G429130 Helicase C-terminal domain-containing protein Cucumis sativus
TI:3659 None
 
A0A0A0L812_CUCSA
neXtProt»
0.0
Csa_3G480710 Uncharacterized protein Cucumis sativus
TI:3659 None
 
A0A0A0LDD0_CUCSA
neXtProt»
0.0
Csa_3G481210 Methyltransferase-like protein 22 Cucumis sativus
TI:3659 None
 
A0A1W0W7K6_SORBI
euHCVdb»
0.0
SORBI_3002G393332 Methyltransferase small
domain-containing protein		 Sorghum bicolor
TI:4558 None
 
A0A251PSM0_PRUPE
euHCVdb»
0.0
PRUPE_4G260400 Methyltransferase small
domain-containing protein		 Prunus persica
TI:3760 None
 
A0A2G2YTI9_CAPAN
neXtProt»
0.0
T459_23750 Protein N-lysine methyltransferase METTL21A Capsicum annuum
TI:4072 None
 
A0A2K1KDX9_PHYPA
EnsemblPlants»
0.0
PHYPA_008358 Uncharacterized protein Physcomitrium patens
TI:3218 None
 
A0A2K1XFK9_POPTR
euHCVdb»
0.0
POPTR_016G141800 Uncharacterized protein Populus trichocarpa
TI:3694 None
 
A0A2K1XW09_POPTR
euHCVdb»
0.0
POPTR_014G149100 Uncharacterized protein Populus trichocarpa
TI:3694 None
 
A0A804MTF2_MAIZE
EnsemblPlants»
0.0
Uncharacterized protein Zea mays
TI:4577 None
   
A0A804QFB7_MAIZE
EnsemblPlants»
0.0
Protein N-lysine methyltransferase METTL21A Zea mays
TI:4577 None
   
A0A9R1VJ34_LACSA
neXtProt»
0.0
LSAT_V11C500252030 Calmodulin-lysine N-methyltransferase Lactuca sativa
TI:4236 None
 
A7SLE1_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g214080 Methyltransferase-like protein 22 Nematostella vectensis
TI:45351 None
 
B9SXW6_RICCO
neXtProt»
0.0
RCOM_0974550 Uncharacterized protein Ricinus communis
TI:3988 None
 
D7T198_VITVI
neXtProt»
0.0
VIT_06s0009g02670 Uncharacterized protein Vitis vinifera
TI:29760 None
 
D8R680_SELML
euHCVdb»
0.0
SELMODRAFT_407627 Uncharacterized protein Selaginella moellendorffii
TI:88036 None