Collated Gene Ontology terms

Biological process: oxidoreductase activity(2012, 2025) D-amino-acid dehydrogenase activity(2011, 2015, 2017, 2019, 2025) metal ion binding(2025) iron-sulfur cluster binding(2025) 2 iron, 2 sulfur cluster binding(2025) tRNA (5-methylaminomethyl-2-thiouridylate)(34)-methyltransferase activity(2011, 2017, 2025) flavin adenine dinucleotide binding(2025) transferase activity(2025) oxidoreductase activity, acting on the CH-NH group of donors(2025) methyltransferase activity(2025)
catalytic activity2025 S-adenosylmethionine-dependent methyltransferase activity2025 D-amino-acid oxidase activity2023, 2024, 2025 glycine oxidase activity2017, 2025 sarcosine oxidase activity2016, 2019, 2025 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen2025 monooxygenase activity2025 FAD binding2011, 2017, 2023 sarcosine dehydrogenase activity2017, 2025 nucleotide binding2025 aminomethyltransferase activity2025 L-amino-acid oxidase activity2025 D-aspartate oxidase activity2024, 2025 protein homodimerization activity2021 proline dehydrogenase activity2016 potassium ion transmembrane transporter activity2025 identical protein binding2019 glycine dehydrogenase (cyanide-forming) activity2025 glycerol-3-phosphate dehydrogenase (quinone) activity2025 calcium-dependent protein serine/threonine phosphatase regulator activity2024 NADH dehydrogenase activity2019 (S)-2-hydroxyglutarate dehydrogenase activity2025

Molecular function: mitochondrial respiratory chain complex I assembly2015, 2017, 2024, 2025 retrograde transport, endosome to Golgi2013, 2017 respiratory electron transport chain2025 D-alanine catabolic process2017, 2021, 2024 D-amino acid catabolic process2023, 2025 thiamine biosynthetic process2017, 2025 tRNA processing2025 methylation2025 thiamine diphosphate biosynthetic process2024 tRNA wobble uridine modification2013, 2017
tRNA wobble base modification2025 positive regulation of pyruvate decarboxylation to acetyl-CoA2025 sarcosine catabolic process2017, 2019 glycine decarboxylation via glycine cleavage system2025 putrescine catabolic process2021, 2024 arginine metabolic process2015 L-arginine catabolic process2015 trans-4-hydroxy-L-proline catabolic process2019 tetrahydrofolate metabolic process2025 tRNA methylation2011 small molecule metabolic process2025 response to herbicide2025 potassium ion transport2025 potassium ion transmembrane transport2025 polyamine catabolic process2019 nitrogen utilization2024 glycerol-3-phosphate metabolic process2025 glycerol catabolic process2024 amino acid metabolic process2017 L-alanine oxidation to pyruvate via D-alanine2021

Cellular component: cytoplasm2013, 2017, 2023, 2025 mitochondrion2009, 2010, 2014, 2017, 2024, 2025 mitochondrial inner membrane2015, 2024, 2025 mitochondrial matrix2024, 2025 late endosome2013, 2017, 2025 plasma membrane2011, 2017, 2025 cytosol2009, 2025 membrane2025 chloroplast2018 mitochondrial outer membrane2015
sarcosine oxidase complex2016 pyruvate dehydrogenase complex2024 peptidoglycan-based cell wall2023 oxidoreductase complex2019 nucleus2018 mitochondrial pyruvate dehydrogenase (lipoamide) phosphatase complex2024 NADH dehydrogenase complex2019

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 15/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 2/4 
Harosa: 3/4 
Hacrobia: 0/0 
Plants: 39/39 
Archea: 6/8 
Bacteria: 27/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
A0A8I5ZVU4_RAT
RGD»
0.0
Pdpr Pyruvate dehydrogenase
phosphatase regulatory subunit		 Rattus norvegicus
TI:10116 None 		     
A0A8V0ZUV6_CHICK
Ensembl»
0.5
FOXRED1 FAD-dependent oxidoreductase
domain-containing protein 1		 Gallus gallus
TI:9031 None
   
A1Z6N5_DROME
FlyBase»
1.0
Dmel\CG3270 FAD-dependent oxidoreductase
domain-containing protein 1		 Drosophila melanogaster
TI:7227 None
 
A8WG78_DANRE
ZFIN»
0.5
foxred1 FAD-dependent oxidoreductase
domain-containing protein 1		 Danio rerio
TI:7955 None
 
D3ZEH2_RAT
RGD»
1.0
Foxred1 FAD-dependent oxidoreductase
domain-containing protein 1		 Rattus norvegicus
TI:10116 None
   
DADA_ECOLI
EnsemblBacteria»
4.2
dadA D-amino acid dehydrogenase
(EC 1.4.99.-) (D-alanine dehydrogenase)		 Escherichia coli
TI:562 None
 
FXRD1_DROME
FlyBase»
0.5
l(2)37Bb FAD-dependent oxidoreductase domain-containing protein 1
homolog (dFOXRED1) (Protein lethal (2) 37Bb)		 Drosophila melanogaster
TI:7227 None
 
FXRD1_HUMAN
Ensembl»
1.3
FOXRED1 FAD-dependent oxidoreductase domain-containing
protein 1 (EC 1.-.-.-)		 Homo sapiens
TI:9606 None
 
FXRD1_MOUSE
Ensembl»
1.5
Foxred1 FAD-dependent oxidoreductase domain-containing
protein 1 (EC 1.-.-.-)		 Mus musculus
TI:10090 None
 
MNMC_ECOLI
EnsemblBacteria»
4.2
mnmC tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC (tRNA mnm(5)s(2)U biosynthesis bifunctional
protein) [Includes: tRNA (mnm(5)s(2)U34)-methyltransferase (EC 2.1.1.61); FAD-dependent cmnm(5)s(2)U34 oxidoreductase (EC 1.5.-.-)]		 Escherichia coli
TI:562 None
 
PDPR_MOUSE
Ensembl»
0.5
Pdpr Pyruvate dehydrogenase phosphatase
regulatory subunit, mitochondrial (PDPr)		 Mus musculus
TI:10090 None
 
PUUB_ECOLI
EnsemblBacteria»
1.6
puuB Gamma-glutamylputrescine oxidoreductase (Gamma-Glu-Put oxidase)
(Gamma-glutamylputrescine oxidase) (EC 1.4.3.-)		 Escherichia coli
TI:562 None
 
Q21504_CAEEL
WormBase»
1.0
CELE_M04B2.4 M04B2.4 FAD-dependent oxidoreductase
domain-containing protein 1		 Caenorhabditis elegans
TI:6239 None
 
Q55FP7_DICDI
dictyBase»
0.0
DDB_G0268008 FAD dependent
oxidoreductase domain-containing protein		 Dictyostelium discoideum
TI:44689 None
 
Q5S4X7_ARATH
TAIR»
0.0
At2g22650 FAD-dependent oxidoreductase family protein Arabidopsis thaliana
TI:3702 None
 
Q9FN21_ARATH
TAIR»
0.0
At5g67290 FAD-dependent oxidoreductase family protein
(Similarity to unknown protein)		 Arabidopsis thaliana
TI:3702 None
 
Q9LV69_ARATH
TAIR»
0.0
MJE7.7 FAD-dependent oxidoreductase
domain-containing protein 1		 Arabidopsis thaliana
TI:3702 None
 
TDA3_YEAST
SGD»
2.9
TDA3 Putative oxidoreductase TDA3 (EC 1.-.-.-) (Batten disease
protein 3) (Topoisomerase I damage affected protein 3)		 Saccharomyces cerevisiae
TI:4932 None
 
YAM3_SCHPO
PomBase»
0.5
SPAC1F5.03c Putative oxidoreductase C1F5.03c (EC 1.-.-.-) Schizosaccharomyces pombe
TI:4896 None
 
YE66_SCHPO
PomBase»
0.5
SPAC6G10.06 Putative oxidoreductase C6G10.06 (EC 1.-.-.-) Schizosaccharomyces pombe
TI:4896 None