Collated Gene Ontology terms

Biological process: first spliceosomal transesterification activity(2025)

Molecular function: mRNA splicing, via spliceosome2013, 2019, 2024, 2025 mRNA processing2025 RNA splicing2025 meiotic cell cycle2014, 2025 feminization of hermaphroditic germ-line2011, 2025 mRNA cis splicing, via spliceosome2024

Cellular component: nucleus2011, 2018, 2019, 2025 spliceosomal complex2025 U2-type spliceosomal complex2013, 2020, 2025 U2-type catalytic step 1 spliceosome2019, 2025 nuclear speck2024, 2025 Prp19 complex2024, 2025 nucleoplasm2016 cytoplasm2009

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 12/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 1/4 
Harosa: 3/4 
Hacrobia: 0/0 
Plants: 39/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
U5D977_AMBTC
euHCVdb»
0.0
AMTR_s00061p00048040 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Amborella trichopoda
TI:13333 None
 
U5DF27_AMBTC
neXtProt»
0.0
AMTR_s00061p00046260 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Amborella trichopoda
TI:13333 None
 
A0A803U0C6_ANOCA
Ensembl»
0.0
CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Anolis carolinensis
TI:28377 None
   
G1KNA8_ANOCA
Ensembl»
0.0
Uncharacterized protein Anolis carolinensis
TI:28377 None 		     
A0A1S4GZ58_ANOGA
EnsemblMetazoa»
0.0
Cir_N domain-containing protein Anopheles gambiae
TI:7165 None
 
O64855_ARATH
TAIR»
0.5
At2g44200 At2g44200/F6E13.34 (Expressed protein) (Pre-mRNA
splicing factor domain-containing protein)		 Arabidopsis thaliana
TI:3702 None
 
Q1PEU6_ARATH
TAIR»
0.0
At2g44195 Pre-mRNA splicing
factor domain-containing protein		 Arabidopsis thaliana
TI:3702 None
 
CWC25_ASPFU
EnsemblFungi»
0.0
cwc25 Pre-mRNA-splicing factor cwc25 Aspergillus fumigatus
TI:746128 None
 
F4NYD7_BATDJ
euHCVdb»
0.0
BATDEDRAFT_86738 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Batrachochytrium dendrobatidis
TI:109871 None
 
F1MER3_BOVIN
Ensembl»
0.0
CWC25 CWC25 spliceosome associated protein homolog Bos taurus
TI:9913 None
   
I1I8B2_BRADI
EnsemblPlants»
0.0
LOC100836983 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Brachypodium distachyon
TI:15368 None
 
A0A9J7K8T7_BRAFL
neXtProt»
0.0
LOC118405747 Pre-mRNA-splicing factor CWC25 homolog Branchiostoma floridae
TI:7739 None
   
A0A078FYI1_BRANA
euHCVdb»
0.0
BnaC04g03420D BnaC04g03420D protein Brassica napus
TI:3708 None
 
M4C818_BRACM
EnsemblPlants»
0.0
CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Brassica campestris
TI:3711 None
   
M4CKS7_BRACM
EnsemblPlants»
0.0
CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Brassica campestris
TI:3711 None
   
G5EBT5_CAEEL
WormBase»
2.1
mog-3 Pre-mRNA-splicing factor CWC25 homolog
(Sex determining protein MOG-3)		 Caenorhabditis elegans
TI:6239 None
 
Q155W6_CAEBR
WormBase»
0.0
mog-3 Protein CBG24673 (Sex determining protein MOG-3) Caenorhabditis briggsae
TI:6238 None
 
A0A8I3RXU1_CANLF
Ensembl»
0.0
CWC25 CWC25 spliceosome associated protein homolog Canis lupus
TI:9612 None
   
A0A1U8FP88_CAPAN
euHCVdb»
0.0
T459_06270 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Capsicum annuum
TI:4072 None
 
A0A2K3E660_CHLRE
neXtProt»
0.0
CHLRE_01g021400v5 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Chlamydomonas reinhardtii
TI:3055 None
 
A0A067GT43_CITSI
euHCVdb»
0.0
CISIN_1g014532mg CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Citrus sinensis
TI:2711 None
 
CWC25_CRYD1
EnsemblFungi»
0.0
CWC25 Pre-mRNA-splicing factor CWC25 Cryptococcus deneoformans
TI:40410 None
 
A0A0A0KU62_CUCSA
euHCVdb»
0.0
Csa_4G025080 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Cucumis sativus
TI:3659 None
 
Q7ZVW8_DANRE
ZFIN»
0.5
cwc25 CWC25 spliceosome-associated protein homolog (Coiled-coil domain
containing 49) (Pate) (Pre-mRNA-splicing factor CWC25 homolog)		 Danio rerio
TI:7955 None
 
E9HFH9_DAPPU
neXtProt»
0.0
DAPPUDRAFT_300923 Uncharacterized protein Daphnia pulex
TI:6669 None
 
F1A1Y9_DICPU
TubercuList»
0.0
DICPUDRAFT_99731 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Dictyostelium purpureum
TI:5786 None
 
Q54QF2_DICDI
dictyBase»
0.5
DDB_G0283901 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Dictyostelium discoideum
TI:44689 None
 
Q9VQF5_DROME
FlyBase»
0.5
Cwc25 Cwc25 (LD47748p) Drosophila melanogaster
TI:7227 None
 
CWC25_EMENI
EnsemblFungi»
0.0
cwc25 Pre-mRNA-splicing factor cwc25 Emericella nidulans
TI:162425 None
 
C4LYR4_ENTH1
TubercuList»
0.0
EHI_004530 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Entamoeba histolytica
TI:5759 None
 
A0A9L0TBC7_HORSE
Ensembl»
0.0
CWC25 CWC25 spliceosome associated protein homolog Equus caballus
TI:9796 None
   
A0A022QK17_ERYGU
euHCVdb»
0.0
MIMGU_mgv1a007356mg CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Erythranthe guttata
TI:4155 None
 
A0ABI8AE04_FELCA
Ensembl»
0.0
CWC25 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Felis catus
TI:9685 None
   
E1BYR4_CHICK
Ensembl»
0.5
CWC25 CWC25 spliceosome associated protein homolog Gallus gallus
TI:9031 None
   
A0A0R0G8I6_SOYBN
EnsemblPlants»
0.0
LOC100779273 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Glycine max
TI:3847 None
 
I1L084_SOYBN
EnsemblPlants»
0.0
LOC100796664 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Glycine max
TI:3847 None
 
G3QVZ1_GORGO
Ensembl»
0.0
CWC25 CWC25 spliceosome associated protein homolog Gorilla gorilla
TI:9593 None
 
A0A1U8J3Q9_GOSHI
euHCVdb»
0.0
LOC107903419 Pre-mRNA-splicing factor CWC25 homolog Gossypium hirsutum
TI:3635 None
   
A0A1U8LLI2_GOSHI
euHCVdb»
0.0
LOC107927486 Pre-mRNA-splicing factor CWC25 homolog Gossypium hirsutum
TI:3635 None
   
A0A251RSE3_HELAN
euHCVdb»
0.0
HannXRQ_Chr17g0558521 HanXRQr2_Chr17g0813071 CBF1-interacting co-repressor CIR domain, pre-mRNA splicing
factor (Putative CBF1-interacting co-repressor CIR,Pre-mRNA splicing factor)		 Helianthus annuus
TI:4232 None
 
T1FQ54_HELRO
EnsemblMetazoa»
0.0
20210951 Uncharacterized protein Helobdella robusta
TI:6412 None
 
CWC25_HUMAN
Ensembl»
1.9
CWC25 Pre-mRNA-splicing factor CWC25 homolog (Coiled-coil domain-containing
protein 49) (Spliceosome-associated protein homolog CWC25)		 Homo sapiens
TI:9606 None
 
F2DKE8_HORVV
EnsemblPlants»
0.0
LOC123407172 Predicted protein Hordeum vulgare
TI:4513 None
 
B7Q8A5_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW020899 Coiled-coil domain-containing protein, putative Ixodes scapularis
TI:6945 None
 
A0A2I4E1E7_JUGRE
neXtProt»
0.0
LOC108985397 Pre-mRNA-splicing factor CWC25 homolog Juglans regia
TI:51240 None
   
A0A1Y1I7P1_KLENI
euHCVdb»
0.0
KFL_002020130 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Klebsormidium nitens
TI:105231 None
 
A0A9R1VUE7_LACSA
euHCVdb»
0.0
LSAT_V11C400182360 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Lactuca sativa
TI:4236 None
 
A0A9R1XU12_LACSA
euHCVdb»
0.0
LSAT_V11C100025010 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Lactuca sativa
TI:4236 None
 
W5N8E2_LEPOC
Ensembl»
0.0
CWC25 spliceosome associated protein homolog Lepisosteus oculatus
TI:7918 None
 
F7GZY8_MACMU
Ensembl»
0.0
CWC25 CWC25 spliceosome associated protein homolog Macaca mulatta
TI:9544 None
   
A0A251L8N0_MANES
euHCVdb»
0.0
MANES_03G095600 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Manihot esculenta
TI:3983 None
 
A0A2R6WDR7_MARPO
euHCVdb»
0.0
MARPO_0104s0032 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Marchantia polymorpha
TI:3197 None
 
G7ISR9_MEDTR
EnsemblPlants»
0.0
11413607 Pre-mRNA splicing factor Medicago truncatula
TI:3880 None
 
F6WUE3_MONDO
Ensembl»
0.0
CWC25 CWC25 spliceosome associated protein homolog Monodelphis domestica
TI:13616 None
   
CWC25_MOUSE
Ensembl»
1.5
Cwc25 Pre-mRNA-splicing factor CWC25 homolog (Coiled-coil domain-containing
protein 49) (Spliceosome-associated protein homolog CWC25)		 Mus musculus
TI:10090 None
 
A0A804JYC9_MUSAM
EnsemblPlants»
0.0
CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Musa acuminata
TI:4641 None
   
A0A804L2H9_MUSAM
EnsemblPlants»
0.0
Uncharacterized protein Musa acuminata
TI:4641 None
   
A0A804L2I4_MUSAM
EnsemblPlants»
0.0
Uncharacterized protein Musa acuminata
TI:4641 None
   
A0A1U8B0F3_NELNU
euHCVdb»
0.0
LOC104608293 Pre-mRNA-splicing factor CWC25 homolog Nelumbo nucifera
TI:4432 None
   
A7RRX2_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g162067 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Nematostella vectensis
TI:45351 None
 
CWC25_NEUCR
EnsemblFungi»
0.0
msp-6 Pre-mRNA-splicing factor cwc25
(mRNA-splicing protein 6)		 Neurospora crassa
TI:5141 None
 
A0A1S3ZXG6_TOBAC
euHCVdb»
0.0
LOC107791468 Pre-mRNA-splicing factor CWC25
homolog (Uncharacterized protein LOC107791468)		 Nicotiana tabacum
TI:4097 None
   
A0A1S4DPI6_TOBAC
euHCVdb»
0.0
LOC107832045 Pre-mRNA-splicing factor CWC25
homolog (Uncharacterized protein LOC107832045)		 Nicotiana tabacum
TI:4097 None
   
A0A6I8PCY9_ORNAN
Ensembl»
0.0
CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Ornithorhynchus anatinus
TI:9258 None
   
F6YEN5_ORNAN
Ensembl»
0.0
CWC25 CWC25 spliceosome associated protein homolog Ornithorhynchus anatinus
TI:9258 None
   
Q6ZKL9_ORYSJ
euHCVdb»
0.0
Os08g0500200 Os08g0500200 protein (cDNA
clone:001-124-H11, full insert sequence)		 Oryza sativa
TI:4530 None
 
H2MWH2_ORYLA
Ensembl»
0.0
CWC25 CWC25 spliceosome associated protein homolog Oryzias latipes
TI:8090 None
   
H2REZ3_PANTR
Ensembl»
0.0
CWC25 CWC25 spliceosome associated protein homolog Pan troglodytes
TI:9598 None
 
A0BLQ7_PARTE
euHCVdb»
0.0
GSPATT00030108001 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Paramecium tetraurelia
TI:5888 None
 
A0A7U2FC80_PHANO
TubercuList»
0.0
JI435_071830 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Phaeosphaeria nodorum
TI:13684 None
 
A0A2K1KTW0_PHYPA
EnsemblPlants»
0.0
LOC112280129 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Physcomitrium patens
TI:3218 None
 
H3GBU5_PHYRM
EnsemblProtists»
0.0
CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Phytophthora ramorum
TI:164328 None
 
B9HBS4_POPTR
euHCVdb»
0.0
POPTR_006G000200 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Populus trichocarpa
TI:3694 None
 
U5FN24_POPTR
neXtProt»
0.0
POPTR_016G000501v4 Uncharacterized protein Populus trichocarpa
TI:3694 None 		 
 
A0A454Y6U0_PRIPA
EnsemblMetazoa»
0.0
WBGene00114985 Mog-3 Pristionchus pacificus
TI:54126 None
   
A0A251QY92_PRUPE
euHCVdb»
0.0
PRUPE_1G161500 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Prunus persica
TI:3760 None
 
A0A251QYA2_PRUPE
euHCVdb»
0.0
PRUPE_1G162300 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Prunus persica
TI:3760 None
 
A0A251QYE3_PRUPE
euHCVdb»
0.0
PRUPE_1G161200 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Prunus persica
TI:3760 None
 
E3K445_PUCGT
TubercuList»
0.0
PGTG_04803 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Puccinia graminis
TI:5297 None
 
G3V6I3_RAT
RGD»
0.5
Cwc25 CWC25 spliceosome-associated protein homolog Rattus norvegicus
TI:10116 None
   
B9SGX7_RICCO
neXtProt»
0.0
RCOM_0820860 Expressed protein, putative Ricinus communis
TI:3988 None
 
CWC25_YEAST
SGD»
2.2
CWC25 Pre-mRNA-splicing factor CWC25 (Complexed
with CEF1 protein 25)		 Saccharomyces cerevisiae
TI:4932 None
 
B6K5L7_SCHJY
TubercuList»
0.0
cwf25 Complexed with Cdc5 protein Cwf25 Schizosaccharomyces japonicus
TI:4897 None
 
CWC25_SCHPO
PomBase»
1.3
cwf25 Pre-mRNA-splicing factor cwf25 (Complexed
with cdc5 protein 25)		 Schizosaccharomyces pombe
TI:4896 None
 
A7EBT2_SCLS1
TubercuList»
0.0
SS1G_02768 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Sclerotinia sclerotiorum
TI:5180 None
 
D8REV9_SELML
euHCVdb»
0.0
SELMODRAFT_410478 Uncharacterized protein Selaginella moellendorffii
TI:88036 None
 
D8REW1_SELML
euHCVdb»
0.0
SELMODRAFT_410480 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Selaginella moellendorffii
TI:88036 None
 
D8REW4_SELML
euHCVdb»
0.0
SELMODRAFT_410483 Uncharacterized protein Selaginella moellendorffii
TI:88036 None
 
D8REX2_SELML
euHCVdb»
0.0
SELMODRAFT_410488 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Selaginella moellendorffii
TI:88036 None
 
D8RIF0_SELML
euHCVdb»
0.0
SELMODRAFT_94554 Uncharacterized protein Selaginella moellendorffii
TI:88036 None 		 
 
D8RIF6_SELML
euHCVdb»
0.0
SELMODRAFT_411594 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Selaginella moellendorffii
TI:88036 None
 
D8RTS3_SELML
euHCVdb»
0.0
SELMODRAFT_232333 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Selaginella moellendorffii
TI:88036 None
 
D8T5D7_SELML
neXtProt»
0.0
SELMODRAFT_132462 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Selaginella moellendorffii
TI:88036 None
 
D8T5D8_SELML
euHCVdb»
0.0
SELMODRAFT_49310 Clathrin light chain Selaginella moellendorffii
TI:88036 None 		 
 
K3YGX8_SETIT
EnsemblPlants»
0.0
LOC101758426 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Setaria italica
TI:4555 None
 
A0A3Q7F829_SOLLC
EnsemblPlants»
0.0
CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Solanum lycopersicum
TI:4081 None
   
M0ZW26_SOLTU
EnsemblPlants»
0.0
LOC102581250 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Solanum tuberosum
TI:4113 None
   
C5YJ72_SORBI
euHCVdb»
0.0
SORBI_3007G216900 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Sorghum bicolor
TI:4558 None
 
A0A9R0I3X5_SPIOL
euHCVdb»
0.0
LOC110782485 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Spinacia oleracea
TI:3562 None
   
A0A7M7N4K2_STRPU
EnsemblMetazoa»
0.0
CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A286ZKR9_PIG
Ensembl»
0.0
CWC25 CWC25 spliceosome associated protein
homolog (Pre-mRNA-splicing factor CWC25 homolog)		 Sus scrofa
TI:9823 None
 
B8CBY4_THAPS
neXtProt»
0.0
THAPSDRAFT_269723 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Thalassiosira pseudonana
TI:35128 None
 
A0A061EQH5_THECC
neXtProt»
0.0
TCM_019804 CBF1-interacting co-repressor CIR isoform 1 Theobroma cacao
TI:3641 None
 
D6WNG6_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_13151 Uncharacterized protein Tribolium castaneum
TI:7070 None
 
A2FV05_TRIV3
TubercuList»
0.0
TVAG_256310 1300013D05Rik protein, putative Trichomonas vaginalis
TI:5722 None
 
B3RRF9_TRIAD
CTD»
0.0
TRIADDRAFT_54223 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Trichoplax adhaerens
TI:10228 None
 
A0A3B6RHN4_WHEAT
EnsemblPlants»
0.0
LOC123151004 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Triticum aestivum
TI:4565 None
   
A0A3B6SI69_WHEAT
EnsemblPlants»
0.0
LOC123161532 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Triticum aestivum
TI:4565 None
   
A0A3B6TDK7_WHEAT
EnsemblPlants»
0.0
LOC123165253 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Triticum aestivum
TI:4565 None
   
F6GWL6_VITVI
euHCVdb»
0.0
VIT_04s0023g03630 CBF1-interacting co-repressor CIR
N-terminal domain-containing protein		 Vitis vinifera
TI:29760 None
 
B0BMD3_XENTR
Xenbase»
0.0
cwc25 LOC100145020 protein (Pre-mRNA-splicing
factor CWC25 homolog)		 Xenopus tropicalis
TI:8364 None
 
Q6DFD5_XENLA
Xenbase»
0.0
cwc25.L AF549897-prov protein (CWC25 spliceosome-associated
protein homolog L homeolog)		 Xenopus laevis
TI:8355 None
 
Q6DFK9_XENLA
Xenbase»
0.0
cwc25.S CWC25 spliceosome-associated protein homolog
S homeolog (MGC81258 protein)		 Xenopus laevis
TI:8355 None
 
CWC25_YARLI
EnsemblFungi»
0.0
CWC25 Pre-mRNA-splicing factor CWC25 Yarrowia lipolytica
TI:4952 None
 
A0A804MMH3_MAIZE
EnsemblPlants»
0.0
Uncharacterized protein Zea mays
TI:4577 None
   
C0PH10_MAIZE
EnsemblPlants»
0.0
LOC100383562 CBF1-interacting co-repressor CIR N-terminal Zea mays
TI:4577 None
 
A0A0K9NT22_ZOSMR
euHCVdb»
0.0
ZOSMA_6G01130 Pre-mRNA-splicing factor cwc25 Zostera marina
TI:29655 None