Collated Gene Ontology terms

Biological process: NF-kappaB binding(2008, 2012, 2019, 2024) phosphatidylinositol binding(2024) actin binding(2024)

Molecular function: tumor necrosis factor-mediated signaling pathway2008, 2019, 2024 negative regulation of DNA-templated transcription2008, 2019, 2024 negative regulation of NF-kappaB transcription factor activity2008, 2012, 2024

Cellular component: cytosol2023, 2024 cytoplasm2010, 2024 nucleus2024 nucleoplasm2023, 2024 plasma membrane2023, 2024 intracellular membrane-bounded organelle2023, 2024 cytoplasmic vesicle2024 membrane2024

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 1/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 1/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 1/4 
Harosa: 2/4 
Hacrobia: 0/0 
Plants: 4/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
Q7PX47_ANOGA
EnsemblMetazoa»
0.0
1281962 AGAP001207-PA Anopheles gambiae
TI:7165 None 		 
 
A0A0G2K6N9_RAT
RGD»
0.0
Commd4 COMM domain containing 4 Rattus norvegicus
TI:10116 None 		     
A0A1D5R2Y8_MACMU
Ensembl»
0.0
COMMD4 COMM domain containing 4 Macaca mulatta
TI:9544 None
   
A0A2I2Y8M7_GORGO
Ensembl»
0.0
COMMD4 COMM domain containing 4 Gorilla gorilla
TI:9593 None 		 
 
A0A2I3SJD0_PANTR
Ensembl»
0.0
COMM domain containing 4 Pan troglodytes
TI:9598 None 		 
 
A0A337S5E2_FELCA
Ensembl»
0.0
COMMD4 COMM domain containing 4 Felis catus
TI:9685 None
 
A0A803KGR8_XENTR
Xenbase»
0.0
commd4 COMM domain containing 4
(COMM domain-containing protein 4)		 Xenopus tropicalis
TI:8364 None 		 
 
A0A8I3PA20_CANLF
Ensembl»
0.0
COMMD4 COMM domain containing 4 Canis lupus
TI:9612 None 		     
A0A8V0ZHP7_CHICK
Ensembl»
0.0
COMMD4 COMM domain containing 4 Gallus gallus
TI:9031 None 		     
A0A8W4FNB9_PIG
Ensembl»
0.0
COMMD4 COMM domain containing 4 Sus scrofa
TI:9823 None
   
F7BPN2_MONDO
Ensembl»
0.0
COMMD4 COMM domain containing 4 Monodelphis domestica
TI:13616 None 		     
F7FP75_ORNAN
Ensembl»
0.0
COMMD4 COMM domain containing 4 Ornithorhynchus anatinus
TI:9258 None
   
G3S9V3_GORGO
Ensembl»
0.0
COMM domain containing 4 Gorilla gorilla
TI:9593 None 		 
 
H2LSN5_ORYLA
Ensembl»
0.0
commd4 COMM domain containing 4 Oryzias latipes
TI:8090 None 		     
H2Q9T9_PANTR
Ensembl»
0.0
COMMD4 COMM domain containing 4 Pan troglodytes
TI:9598 None 		 
 
Q6AZR8_XENLA
Xenbase»
0.0
commd4.S COMM domain containing 4
S homeolog (LOC594868 protein)		 Xenopus laevis
TI:8355 None 		 
 
W5NCJ5_LEPOC
Ensembl»
0.0
COMM domain containing 4 Lepisosteus oculatus
TI:7918 None 		 
 
A0A2I3S6X3_PANTR
Ensembl»
0.0
COMMD6 COMM domain containing 6 Pan troglodytes
TI:9598 None
 
A0A3B3I037_ORYLA
Ensembl»
0.0
commd6 COMM domain containing 6 Oryzias latipes
TI:8090 None
   
A0A8I3PMX8_CANLF
Ensembl»
0.0
COMMD6 COMM domain containing 6 Canis lupus
TI:9612 None 		     
D4A8E7_RAT
RGD»
1.0
Commd6 COMM domain containing 6 Rattus norvegicus
TI:10116 None
   
F6YTA7_HORSE
Ensembl»
0.0
COMMD6 COMM domain containing 6 Equus caballus
TI:9796 None
   
F7GXX0_MACMU
Ensembl»
0.0
COMMD6 COMM domain containing 6 Macaca mulatta
TI:9544 None
   
G1KA41_ANOCA
Ensembl»
0.0
commd6 COMM domain containing 6 Anolis carolinensis
TI:28377 None
   
G3R0S5_GORGO
Ensembl»
0.0
COMM domain containing 6 Gorilla gorilla
TI:9593 None
 
M3WUJ0_FELCA
Ensembl»
0.0
COMMD6 COMM domain containing 6 Felis catus
TI:9685 None
 
W5N039_LEPOC
Ensembl»
0.0
COMM domain containing 6 Lepisosteus oculatus
TI:7918 None
 
A0A287B1U5_PIG
Ensembl»
0.0
COMMD7 COMM domain containing 7 Sus scrofa
TI:9823 None
   
A0A2I3TG85_PANTR
Ensembl»
0.0
COMMD7 COMM domain containing 7 Pan troglodytes
TI:9598 None
 
A0A3B3HCI5_ORYLA
Ensembl»
0.0
commd7 COMM domain containing 7 Oryzias latipes
TI:8090 None
   
A0A6I8N848_ORNAN
Ensembl»
0.0
COMMD7 COMM domain containing 7 Ornithorhynchus anatinus
TI:9258 None
   
A0A8I3PP17_CANLF
Ensembl»
0.0
COMMD7 COMM domain containing 7 Canis lupus
TI:9612 None
   
A0A8V0YMD9_CHICK
Ensembl»
0.0
COMMD7 COMM domain containing 7 Gallus gallus
TI:9031 None 		     
F6RXG2_MONDO
Ensembl»
0.0
COMMD7 COMM domain containing 7 Monodelphis domestica
TI:13616 None
   
F7FBG3_RAT
RGD»
3.0
Commd7 COMM domain containing 7 Rattus norvegicus
TI:10116 None
   
F7GIJ9_MACMU
Ensembl»
0.0
COMMD7 COMM domain containing 7 Macaca mulatta
TI:9544 None 		     
G3RYE1_GORGO
Ensembl»
0.0
COMM domain containing 7 Gorilla gorilla
TI:9593 None 		 
 
W5MEU3_LEPOC
Ensembl»
0.0
COMM domain containing 7 Lepisosteus oculatus
TI:7918 None
 
A0A5F5XS47_FELCA
Ensembl»
0.0
COMMD8 COMM domain containing 8 Felis catus
TI:9685 None
 
A0A6I8PRX7_ORNAN
Ensembl»
0.0
COMMD8 COMM domain containing 8 Ornithorhynchus anatinus
TI:9258 None 		     
A0A803TYY7_ANOCA
Ensembl»
0.0
COMMD8 COMM domain containing 8 Anolis carolinensis
TI:28377 None 		     
A0A8I3N9G9_CANLF
Ensembl»
0.0
COMMD8 COMM domain containing 8 Canis lupus
TI:9612 None
   
B0K015_RAT
RGD»
0.0
Commd8 COMM domain containing 8 Rattus norvegicus
TI:10116 None
   
F6ZB31_MONDO
Ensembl»
0.0
COMMD8 COMM domain containing 8 Monodelphis domestica
TI:13616 None
   
F7DER5_MACMU
Ensembl»
0.0
COMMD8 COMM domain containing 8 Macaca mulatta
TI:9544 None 		     
G3SGK7_GORGO
Ensembl»
0.0
COMMD8 COMM domain containing 8 Gorilla gorilla
TI:9593 None
 
H2MV22_ORYLA
Ensembl»
0.0
commd8 COMM domain containing 8 Oryzias latipes
TI:8090 None 		     
H2QPE9_PANTR
Ensembl»
0.0
COMMD8 COMM domain containing 8 Pan troglodytes
TI:9598 None
 
Q5XHD0_XENLA
Xenbase»
0.0
commd8.S COMM domain containing 8
S homeolog (LOC495034 protein)		 Xenopus laevis
TI:8355 None 		 
 
R4GIV5_CHICK
Ensembl»
0.0
COMMD8 COMM domain containing 8 Gallus gallus
TI:9031 None
   
W5N118_LEPOC
Ensembl»
0.0
COMM domain containing 8 Lepisosteus oculatus
TI:7918 None 		 
 
A0A480XDE4_PIG
Ensembl»
0.0
COMMD8 COMM domain containing 8 (COMM
domain-containing protein 8 isoform X3)		 Sus scrofa
TI:9823 None 		 
 
F1Q509_DANRE
ZFIN»
0.0
zgc:153556 COMM domain-containing 4
(COMM domain-containing protein 4)		 Danio rerio
TI:7955 None 		 
 
E9QCG0_DANRE
ZFIN»
0.5
commd6 COMM domain-containing 6
(COMM domain-containing protein 6)		 Danio rerio
TI:7955 None
 
A0A2I3T1J6_PANTR
Ensembl»
0.0
COMM domain-containing protein Pan troglodytes
TI:9598 None 		 
 
A0A2R8Y455_HUMAN
Ensembl»
0.0
COMM domain-containing protein Homo sapiens
TI:9606 None 		 
 
A0A5F5XC67_FELCA
Ensembl»
0.0
COMM domain-containing protein Felis catus
TI:9685 None
 
A0A6I8PND6_ORNAN
Ensembl»
0.0
COMM domain-containing protein Ornithorhynchus anatinus
TI:9258 None
   
A0A7I4CB31_PHYPA
EnsemblPlants»
0.0
COMM domain-containing protein Physcomitrium patens
TI:3218 None 		 
 
A0A7M7G4D4_STRPU
EnsemblMetazoa»
0.0
COMM domain-containing protein Strongylocentrotus purpuratus
TI:7668 None 		     
A0A7M7NH90_STRPU
EnsemblMetazoa»
0.0
COMM domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7PX64_STRPU
EnsemblMetazoa»
0.0
COMM domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7RCS8_STRPU
EnsemblMetazoa»
0.0
COMM domain-containing protein Strongylocentrotus purpuratus
TI:7668 None 		     
A0A803T2I7_ANOCA
Ensembl»
0.0
COMM domain-containing protein Anolis carolinensis
TI:28377 None 		     
A0A8V0X6G5_CHICK
Ensembl»
0.0
COMMD6 COMM domain-containing protein Gallus gallus
TI:9031 None 		     
A2EKJ1_TRIV3
VEuPathDB»
0.0
TVAG_313930 COMM domain-containing protein Trichomonas vaginalis
TI:5722 None 		 
 
A7RHE2_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g158694 COMM domain-containing protein Nematostella vectensis
TI:45351 None 		 
 
A7RVQ2_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g182498 COMM domain-containing protein Nematostella vectensis
TI:45351 None 		 
 
A7S761_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g243323 COMM domain-containing protein Nematostella vectensis
TI:45351 None
 
A7SFX4_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g116741 COMM domain-containing protein Nematostella vectensis
TI:45351 None
 
A7TCL0_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g225290 COMM domain-containing protein Nematostella vectensis
TI:45351 None 		 
 
A9UVC1_MONBE
EnsemblProtists»
0.0
MONBRDRAFT_31718 COMM domain-containing protein Monosiga brevicollis
TI:81824 None
 
B3RUE7_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_63824 COMM domain-containing protein Trichoplax adhaerens
TI:10228 None
 
B3S867_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_30907 COMM domain-containing protein Trichoplax adhaerens
TI:10228 None 		 
 
C4M395_ENTH1
EnsemblProtists»
0.0
EHI_106310 COMM domain-containing protein Entamoeba histolytica
TI:5759 None 		 
 
D8SFE0_SELML
EnsemblPlants»
0.0
SELMODRAFT_445076 COMM domain-containing protein Selaginella moellendorffii
TI:88036 None 		 
 
E9G1Z6_DAPPU
EnsemblMetazoa»
0.0
DAPPUDRAFT_44231 COMM domain-containing protein Daphnia pulex
TI:6669 None 		 
 
F0ZGS1_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_150605 COMM domain-containing protein Dictyostelium purpureum
TI:5786 None 		 
 
F0ZJF3_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_78396 COMM domain-containing protein Dictyostelium purpureum
TI:5786 None 		 
 
F0ZJL1_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_32706 COMM domain-containing protein Dictyostelium purpureum
TI:5786 None 		 
 
F0ZUK6_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_38509 COMM domain-containing protein Dictyostelium purpureum
TI:5786 None
 
F6SGI9_MONDO
Ensembl»
0.0
COMM domain-containing protein Monodelphis domestica
TI:13616 None
   
F6VII0_MONDO
Ensembl»
0.0
COMM domain-containing protein Monodelphis domestica
TI:13616 None
   
F7FCY9_MONDO
Ensembl»
0.0
COMM domain-containing protein Monodelphis domestica
TI:13616 None
   
G3N1X3_BOVIN
Ensembl»
0.0
LOC101903064 COMM domain-containing protein Bos taurus
TI:9913 None
   
T1ERR5_HELRO
EnsemblMetazoa»
0.0
20199265 COMM domain-containing protein Helobdella robusta
TI:6412 None
 
T1EXW6_HELRO
EnsemblMetazoa»
0.0
20201416 COMM domain-containing protein Helobdella robusta
TI:6412 None
 
T1G418_HELRO
EnsemblMetazoa»
0.0
20215816 COMM domain-containing protein Helobdella robusta
TI:6412 None 		 
 
U5DC92_AMBTC
EnsemblPlants»
0.0
AMTR_s00066p00084370 COMM domain-containing protein Amborella trichopoda
TI:13333 None
 
COMD4_BOVIN
Ensembl»
0.0
COMMD4 COMM domain-containing protein 4 Bos taurus
TI:9913 None
 
COMD4_DICDI
dictyBase»
0.0
commd4 COMM domain-containing protein 4 Dictyostelium discoideum
TI:44689 None 		 
 
COMD4_HUMAN
Ensembl»
0.0
COMMD4 COMM domain-containing protein 4 Homo sapiens
TI:9606 None
 
COMD4_MOUSE
Ensembl»
0.0
Commd4 COMM domain-containing protein 4 Mus musculus
TI:10090 None
 
C3YSG4_BRAFL
CTD»
0.0
LOC118424755 COMM domain-containing protein 4-like Branchiostoma floridae
TI:7739 None 		 
 
H2XWA4_CIOIN
Ensembl»
0.0
LOC100187497 COMM domain-containing protein 4-like Ciona intestinalis
TI:7719 None 		     
D6W6Z5_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_14198 COMM domain-containing protein 4-like Protein Tribolium castaneum
TI:7070 None 		 
 
A0A1L8HHD2_XENLA
Xenbase»
0.0
commd6.L COMM domain-containing protein 6 Xenopus laevis
TI:8355 None
   
A0A8J0UAN6_XENLA
Xenbase»
0.0
commd6.S COMM domain-containing protein 6 Xenopus laevis
TI:8355 None
   
A2DNF6_TRIV3
VEuPathDB»
0.0
TVAG_306660 COMM domain-containing protein 6 Trichomonas vaginalis
TI:5722 None 		 
 
A2E513_TRIV3
VEuPathDB»
0.0
TVAG_027740 COMM domain-containing protein 6 Trichomonas vaginalis
TI:5722 None 		 
 
COMD6_BOVIN
CTD»
0.0
COMMD6 COMM domain-containing protein 6 Bos taurus
TI:9913 None
 
COMD6_DICDI
dictyBase»
0.0
commd6 COMM domain-containing protein 6 Dictyostelium discoideum
TI:44689 None 		 
 
COMD6_HUMAN
Ensembl»
2.1
COMMD6 COMM domain-containing protein 6 Homo sapiens
TI:9606 None
 
COMD6_MOUSE
Ensembl»
0.5
Commd6 COMM domain-containing protein 6 Mus musculus
TI:10090 None
 
COMD6_XENLA
Xenbase»
0.0
commd6 COMM domain-containing protein 6 Xenopus laevis
TI:8355 None
 
COMD6_XENTR
Xenbase»
0.0
commd6 COMM domain-containing protein 6 Xenopus tropicalis
TI:8364 None
 
A0A803KA98_XENTR
Xenbase»
0.0
commd6 COMM domain-containing protein 6 (COMM
domain-containing protein 6 isoform X1)		 Xenopus tropicalis
TI:8364 None 		     
F6ZU44_MONDO
Ensembl»
0.0
LOC100013789 COMM domain-containing protein 6-like Monodelphis domestica
TI:13616 None
   
A0A9J7LGA6_BRAFL
CTD»
0.0
LOC118419856 COMM domain-containing protein 6-like isoform X1
(COMM domain-containing protein 6-like isoform X2)		 Branchiostoma floridae
TI:7739 None 		     
A0A8J1K226_XENTR
Xenbase»
0.0
commd7 COMM domain-containing protein 7 Xenopus tropicalis
TI:8364 None 		     
COMD7_BOVIN
Ensembl»
0.0
COMMD7 COMM domain-containing protein 7 Bos taurus
TI:9913 None
 
COMD7_DICDI
dictyBase»
1.5
commd7 COMM domain-containing protein 7 Dictyostelium discoideum
TI:44689 None
 
COMD7_HUMAN
Ensembl»
4.7
COMMD7 COMM domain-containing protein 7 Homo sapiens
TI:9606 None
 
COMD7_MOUSE
Ensembl»
0.0
Commd7 COMM domain-containing protein 7 Mus musculus
TI:10090 None
 
Q6DBX2_DANRE
ZFIN»
1.5
zgc:101056 COMM domain-containing protein 7 (Zgc:101056) Danio rerio
TI:7955 None
 
A0A8J1M4P4_XENLA
Xenbase»
0.0
commd7.S COMM domain-containing protein 7 isoform X1 Xenopus laevis
TI:8355 None
   
A0A1W2WC94_CIOIN
Ensembl»
0.0
LOC100183378 COMM domain-containing protein 7-like Ciona intestinalis
TI:7719 None
 
A0A9J7KLL6_BRAFL
CTD»
0.0
LOC118408612 COMM domain-containing protein 7-like Branchiostoma floridae
TI:7739 None 		     
COMD8_DICDI
dictyBase»
0.0
commd8 COMM domain-containing protein 8 Dictyostelium discoideum
TI:44689 None 		 
 
COMD8_HUMAN
Ensembl»
0.0
COMMD8 COMM domain-containing protein 8 Homo sapiens
TI:9606 None
 
COMD8_MOUSE
Ensembl»
0.0
Commd8 COMM domain-containing protein 8 Mus musculus
TI:10090 None
 
A0JMG2_DANRE
ZFIN»
0.0
zgc:153407 COMM domain-containing protein 8 (Zgc:153407) Danio rerio
TI:7955 None 		 
 
A0A8J0T247_XENTR
Xenbase»
0.0
commd8 COMM domain-containing protein 8 isoform X1 Xenopus tropicalis
TI:8364 None 		     
A0A9J7KWB9_BRAFL
CTD»
0.0
LOC118412822 COMM domain-containing protein 8-like Branchiostoma floridae
TI:7739 None 		     
D6X063_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_12212 COMM domain-containing protein 8-like Protein Tribolium castaneum
TI:7070 None 		 
 
B7Q021_IXOSC
EnsemblMetazoa»
0.0
8033905 COMM domain-containing protein, putative Ixodes scapularis
TI:6945 None
 
B7Q421_IXOSC
EnsemblMetazoa»
0.0
8035593 COMM domain-containing protein, putative Ixodes scapularis
TI:6945 None
 
B7Q6Q1_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW011120 COMM domain-containing protein, putative Ixodes scapularis
TI:6945 None 		 
 
A0DV65_PARTE
EnsemblProtists»
0.0
GSPATT00020595001 Chromosome undetermined scaffold_65,
whole genome shotgun sequence		 Paramecium tetraurelia
TI:5888 None 		 
 
A0EHZ8_PARTE
EnsemblProtists»
0.0
GSPATT00027266001 Chromosome undetermined scaffold_98,
whole genome shotgun sequence		 Paramecium tetraurelia
TI:5888 None 		 
 
A8E6W0_DROME
FlyBase»
0.0
CG34039-RA IP19808p (IP20008p) Drosophila melanogaster
TI:7227 None 		 
 
H3H279_PHYRM
EnsemblProtists»
0.0
PX domain-containing protein Phytophthora ramorum
TI:164328 None
 
A0A0K3AQR5_CAEEL
WormBase»
0.0
CELE_T28F2.2 T28F2.2 Protein LAZ1 Caenorhabditis elegans
TI:6239 None 		 
 
A0A2I3S8Y2_PANTR
Ensembl»
0.0
Uncharacterized protein Pan troglodytes
TI:9598 None 		 
 
A0A2R6XHU0_MARPO
EnsemblPlants»
0.0
MARPO_0014s0181 Uncharacterized protein Marchantia polymorpha
TI:3197 None 		 
 
D8R5K7_SELML
EnsemblPlants»
0.0
SELMODRAFT_407429 Uncharacterized protein Selaginella moellendorffii
TI:88036 None 		 
 
A0A1L8H081_XENLA
Xenbase»
0.0
commd4.L Uncharacterized protein LOC100126646 isoform X1 Xenopus laevis
TI:8355 None