Collated Gene Ontology terms

Biological process: diphthine methylesterase activity(2015, 2020, 2022, 2023) methyltransferase activity(2023) hydrolase activity(2023) protein methylesterase activity(2020)

Molecular function: peptidyl-diphthamide biosynthetic process from peptidyl-histidine2010, 2012, 2020, 2022, 2023 methylation2023 endocytic recycling2011, 2012, 2023 rRNA processing2019 protein homooligomerization2023 positive regulation of transcription by RNA polymerase I2019 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2021 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2021 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2021

Cellular component: cytoplasm2011, 2017, 2020, 2022, 2023 endosome2011, 2023 nucleus2009, 2023 cytosol2009, 2014 nucleolus2019 Cul4-RING E3 ubiquitin ligase complex2008

Phylogenetic distribution

Chordates: 20/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 16/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 2/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 35/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 0 2 4 6 8 10 Knownness

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A022R279_ERYGU
Ensembl»
0.0
MIMGU_mgv1a026343mg Uncharacterized protein Erythranthe guttata
TI:4155 None
 
A0A059AUI2_EUCGR
EnsemblPlants»
0.0
EUGRSUZ_H00387 Uncharacterized protein Eucalyptus grandis
TI:71139 None
 
A0A059AW06_EUCGR
EnsemblPlants»
0.0
EUGRSUZ_H00383 Uncharacterized protein Eucalyptus grandis
TI:71139 None
 
A0A059CNU2_EUCGR
EnsemblPlants»
0.0
EUGRSUZ_C01244 Uncharacterized protein Eucalyptus grandis
TI:71139 None
 
A0A061G165_THECC
EnsemblPlants»
0.0
TCM_012103 Transducin/WD40 repeat-like superfamily
protein isoform 1		 Theobroma cacao
TI:3641 None
 
A0A067FTT8_CITSI
Ensembl»
0.0
CISIN_1g0201072mg Uncharacterized protein Citrus sinensis
TI:2711 None 		 
   
A0A067G270_CITSI
Ensembl»
0.0
CISIN_1g0201071mg Anaphase-promoting complex subunit
4 WD40 domain-containing protein		 Citrus sinensis
TI:2711 None
 
A0A0A0LS22_CUCSA
EnsemblPlants»
0.0
Csa_1G004880 Uncharacterized protein Cucumis sativus
TI:3659 None
 
A0A0D1CBJ4_USTMA
EnsemblFungi»
0.0
UMAG_01730 Diphthamide biosynthesis protein 7 Ustilago maydis
TI:5270 None
 
A0A0K9P960_ZOSMR
EnsemblPlants»
0.0
ZOSMA_34G00710 WD repeat-containing protein Zostera marina
TI:29655 None
 
A0A0Q3QW90_SETIT
EnsemblPlants»
0.0
Uncharacterized protein Setaria italica
TI:4555 None
 
A0A0R0J0U5_SOYBN
EnsemblPlants»
0.0
GLYMA_08G230900 Uncharacterized protein Glycine max
TI:3847 None
 
A0A1D5P6U5_CHICK
Ensembl»
1.0
DPH7 Diphthamide biosynthesis 7 Gallus gallus
TI:9031 None
   
A0A1D8PI03_CANAL
EnsemblFungi»
0.0
CAALFM_C207920WA orf19.9737 Diphthamide synthase Candida albicans
TI:5476 None
 
A0A1S3Y6V2_TOBAC
EnsemblFungi»
0.0
LOC107772927 Diphthine methyltransferase homolog Nicotiana tabacum
TI:4097 None
   
A0A1U8APL8_NELNU
EnsemblBacteria»
0.0
LOC104606171 Diphthine methyltransferase homolog Nelumbo nucifera
TI:4432 None
 
A0A1U8HYA3_GOSHI
Ensembl»
0.0
LOC107890893 Diphthine methyltransferase homolog Gossypium hirsutum
TI:3635 None
   
A0A1U8LTH3_GOSHI
Ensembl»
0.0
LOC107929722 Diphthine methyltransferase homolog Gossypium hirsutum
TI:3635 None
   
A0A1U8M3I3_GOSHI
Ensembl»
0.0
LOC107933602 Diphthine methyltransferase homolog Gossypium hirsutum
TI:3635 None
   
A0A1Y1IGC3_KLENI
EnsemblPlants»
0.0
KFL_004400060 Uncharacterized conserved protein Klebsormidium nitens
TI:105231 None
 
A0A251P9R5_PRUPE
EnsemblPlants»
0.0
PRUPE_5G171000 Uncharacterized protein Prunus persica
TI:3760 None
 
A0A251RXB0_HELAN
EnsemblPlants»
0.0
HannXRQ_Chr16g0506951 Putative WD40/YVTN
repeat-like-containing domain-containing protein		 Helianthus annuus
TI:4232 None
 
A0A251UXM5_HELAN
EnsemblPlants»
0.0
HannXRQ_Chr04g0107691 HanXRQr2_Chr04g0169911 Putative WD40/YVTN repeat-like-containing domain-containing
protein (Transcription factor WD40-like family)		 Helianthus annuus
TI:4232 None
 
A0A287BE67_PIG
Ensembl»
0.0
DPH7 Diphthamide biosynthesis 7 Sus scrofa
TI:9823 None
   
A0A2C9VPR5_MANES
EnsemblPlants»
0.0
MANES_06G106600 Uncharacterized protein Manihot esculenta
TI:3983 None
 
A0A2I4G1H2_JUGRE
EnsemblPlants»
0.0
LOC109003873 Diphthine methyltransferase homolog Juglans regia
TI:51240 None
 
A0A2K1XN92_POPTR
EnsemblPlants»
0.0
POPTR_014G000900 Uncharacterized protein Populus trichocarpa
TI:3694 None
 
A0A2K2CHD9_BRADI
EnsemblPlants»
0.0
BRADI_5g15180v3 Anaphase-promoting complex subunit
4-like WD40 domain-containing protein		 Brachypodium distachyon
TI:15368 None
 
A0A2K3DA27_CHLRE
EnsemblPlants»
0.0
CHLRE_10g434300v5 Uncharacterized protein Chlamydomonas reinhardtii
TI:3055 None
 
A0A2R6X9W9_MARPO
EnsemblPlants»
0.0
MARPO_0027s0008 Uncharacterized protein Marchantia polymorpha
TI:3197 None
 
A0A2X0S874_WHEAT
EnsemblPlants»
0.0
CAMPLR22A2D_LOCUS3628 Genome assembly, chromosome: II Triticum aestivum
TI:4565 None
 
A0A3B3H3F5_ORYLA
Ensembl»
0.0
dph7 Diphthamide biosynthesis 7 Oryzias latipes
TI:8090 None
   
A0A3B6B0Z3_WHEAT
EnsemblPlants»
0.0
CFC21_017995 Uncharacterized protein Triticum aestivum
TI:4565 None
 
A0A3B6C9H8_WHEAT
EnsemblPlants»
0.0
CFC21_024414 Uncharacterized protein Triticum aestivum
TI:4565 None
 
A0A3Q7GEK8_SOLLC
EnsemblPlants»
0.0
Anaphase-promoting complex subunit
4 WD40 domain-containing protein		 Solanum lycopersicum
TI:4081 None
   
A0A7M7NR30_STRPU
EnsemblMetazoa»
0.0
Uncharacterized protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7P773_STRPU
EnsemblMetazoa»
0.0
Diphthine methyltransferase Strongylocentrotus purpuratus
TI:7668 None
   
A0A803J420_XENTR
Ensembl»
0.0
dph7 Diphthamide biosynthesis
7 (Diphthine methyltransferase)		 Xenopus tropicalis
TI:8364 None
   
A0A804KTJ4_MUSAM
EnsemblPlants»
0.0
104000122 (wild Malaysian banana) hypothetical protein Musa acuminata
TI:4641 None 		 
 
A0A8I3PEL1_CANLF
Ensembl»
0.0
DPH7 Diphthamide biosynthesis 7 Canis lupus
TI:9612 None 		     
A0A8I6WQK1_HORVV
EnsemblPlants»
0.0
Anaphase-promoting complex subunit
4-like WD40 domain-containing protein		 Hordeum vulgare
TI:4513 None 		     
A0A8R1Z8L0_PRIPA
EnsemblMetazoa»
0.0
WBGene00304263 WD40 domain-containing protein Pristionchus pacificus
TI:54126 None
   
A0A9J7M4H9_BRAFL
CTD»
0.0
LOC118428384 Diphthine methyltransferase-like isoform X1 Branchiostoma floridae
TI:7739 None
   
A0A9K3DPL1_HELAN
EnsemblPlants»
0.0
HanXRQr2_Chr16g0734421 Transcription factor WD40-like family Helianthus annuus
TI:4232 None 		 
 
A0A9K3DRM7_HELAN
EnsemblPlants»
0.0
HanXRQr2_Chr16g0734431 Transcription factor WD40-like family Helianthus annuus
TI:4232 None 		 
 
A0A9K3I9K3_HELAN
EnsemblPlants»
0.0
HanXRQr2_Chr09g0410581 Transcription factor WD40-like family Helianthus annuus
TI:4232 None 		 
 
A0BLI8_PARTE
EnsemblProtists»
0.0
GSPATT00030038001 Chromosome undetermined scaffold_114,
whole genome shotgun sequence		 Paramecium tetraurelia
TI:5888 None
 
A3KNN6_DANRE
ZFIN»
1.0
zgc:162277 Diphthamide biosynthesis 7 (Diphthine
methyltransferase (EC 3.1.1.97)) (Zgc:162277 protein)		 Danio rerio
TI:7955 None
 
A7F0L3_SCLS1
EnsemblFungi»
0.0
SS1G_11131 Uncharacterized protein Sclerotinia sclerotiorum
TI:5180 None
 
A7RJK3_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g83583 Diphthine methyltransferase Nematostella vectensis
TI:45351 None
 
A8WKD9_CAEBR
WormBase»
0.0
CBG24288 CBG_24288 Protein CBG24288 Caenorhabditis briggsae
TI:6238 None
 
A9SH84_PHYPA
EnsemblPlants»
0.0
PHYPA_012745 Uncharacterized protein Physcomitrium patens
TI:3218 None
 
A9V3X6_MONBE
EnsemblProtists»
0.0
MONBRDRAFT_26922 Diphthine methyltransferase Monosiga brevicollis
TI:81824 None
 
B3RPV9_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_20606 Uncharacterized protein Trichoplax adhaerens
TI:10228 None
 
B6K7X2_SCHJY
EnsemblFungi»
0.0
SJAG_04846 WRDR85 family WD repeat protein Schizosaccharomyces japonicus
TI:4897 None
 
B7PUA2_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW007684 Uncharacterized protein Ixodes scapularis
TI:6945 None 		 
 
B8CC48_THAPS
EnsemblProtists»
0.0
THAPSDRAFT_24785 BTB domain-containing protein Thalassiosira pseudonana
TI:35128 None
 
B9I3G2_POPTR
EnsemblPlants»
0.0
POPTR_012G087300 Uncharacterized protein Populus trichocarpa
TI:3694 None
 
B9RAZ9_RICCO
EnsemblBacteria»
0.0
RCOM_1510320 Nucleotide binding protein, putative Ricinus communis
TI:3988 None
 
C0HF73_MAIZE
EnsemblPlants»
0.0
100276398 Transducin/WD40 repeat-like superfamily protein Zea mays
TI:4577 None
 
C4M9N2_ENTH1
EnsemblProtists»
0.0
EHI_060980 WD domain containing protein Entamoeba histolytica
TI:5759 None
 
C5YBW3_SORBI
EnsemblPlants»
0.0
SORBI_3006G141000 Anaphase-promoting complex subunit
4-like WD40 domain-containing protein		 Sorghum bicolor
TI:4558 None
 
C6KSS8_PLAF7
EnsemblProtists»
0.0
PF3D7_0608000 Diphthine methyltransferase,
putative (EC 3.1.1.97)		 Plasmodium falciparum
TI:5833 None
 
D4A1S8_RAT
RGD»
2.0
Dph7 Diphthamide biosynthesis 7 Rattus norvegicus
TI:10116 None
   
D6WZ29_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_06759 Diphthamide biosynthesis protein 7-like Protein Tribolium castaneum
TI:7070 None
 
D8QPR8_SELML
EnsemblPlants»
0.0
SELMODRAFT_75309 Uncharacterized protein Selaginella moellendorffii
TI:88036 None
 
D8SKQ9_SELML
EnsemblPlants»
0.0
SELMODRAFT_119414 Uncharacterized protein Selaginella moellendorffii
TI:88036 None
 
DPH7_DICDI
dictyBase»
1.0
wdr85 Diphthine methyltransferase homolog (EC 3.1.1.97) (Diphthamide biosynthesis
protein 7 homolog) (WD repeat-containing protein 85 homolog)		 Dictyostelium discoideum
TI:44689 None
 
DPH7_HUMAN
Ensembl»
1.8
DPH7 Diphthine methyltransferase (EC 3.1.1.97) (Diphthamide biosynthesis
protein 7) (WD repeat-containing protein 85)		 Homo sapiens
TI:9606 None
 
DPH7_MOUSE
Ensembl»
2.0
Dph7 Diphthine methyltransferase (EC 3.1.1.97) (Diphthamide biosynthesis
protein 7) (DPH7) (WD repeat-containing protein 85)		 Mus musculus
TI:10090 None
 
DPH7_SCHPO
PomBase»
2.0
rrt2 Diphthine methyltransferase (EC 3.1.1.97) (Diphthamide biosynthesis
protein 7) (WD repeat-containing protein rrt2)		 Schizosaccharomyces pombe
TI:4896 None
 
DPH7_YEAST
SGD»
5.0
RRT2 Diphthine methyltransferase (EC 3.1.1.97) (Diphthamide biosynthesis protein 7) (Endosomal
recycling protein 1) (Regulator of rDNA transcription protein 2)		 Saccharomyces cerevisiae
TI:4932 None
 
E3KU90_PUCGT
EnsemblFungi»
0.0
PGTG_14580 Diphthine methyltransferase Puccinia graminis
TI:5297 None
 
E9ACD6_LEIMA
EnsemblProtists»
0.0
LMJF_02_0620 Guanine nucleotide-binding protein
subunit beta-like protein		 Leishmania major
TI:5664 None
 
E9GTK0_DAPPU
EnsemblMetazoa»
0.0
DAPPUDRAFT_305903 Uncharacterized protein Daphnia pulex
TI:6669 None
 
F0ZAS1_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_75478 Uncharacterized protein Dictyostelium purpureum
TI:5786 None
 
F1MY10_BOVIN
Ensembl»
0.0
DPH7 Diphthamide biosynthesis 7 Bos taurus
TI:9913 None
   
F4PF24_BATDJ
EnsemblBacteria»
0.0
BATDEDRAFT_28761 Uncharacterized protein Batrachochytrium dendrobatidis
TI:109871 None
 
F6GSM1_VITVI
EnsemblPlants»
0.0
VIT_17s0000g08690 Uncharacterized protein Vitis vinifera
TI:29760 None
 
F6QD47_MONDO
Ensembl»
0.0
DPH7 Diphthamide biosynthesis 7 Monodelphis domestica
TI:13616 None
   
F6YUN5_CIOIN
Ensembl»
0.0
Uncharacterized protein Ciona intestinalis
TI:7719 None
   
F6ZWJ4_HORSE
Ensembl»
0.0
DPH7 Diphthamide biosynthesis 7 Equus caballus
TI:9796 None
   
F7B834_MACMU
Ensembl»
0.0
DPH7 Diphthamide biosynthesis 7 Macaca mulatta
TI:9544 None
   
G3QU58_GORGO
Ensembl»
0.0
DPH7 Diphthamide biosynthesis 7 Gorilla gorilla
TI:9593 None
 
G5EBG2_CAEEL
WormBase»
1.0
dph-7 WD_REPEATS_REGION domain-containing protein Caenorhabditis elegans
TI:6239 None
 
G7KEH9_MEDTR
EnsemblPlants»
0.0
MTR_5g096040 Transducin/WD-like repeat-protein Medicago truncatula
TI:3880 None
 
H2QY86_PANTR
Ensembl»
0.0
DPH7 Diphthamide biosynthesis 7 (WD repeat domain 85) Pan troglodytes
TI:9598 None
 
H3H394_PHYRM
EnsemblProtists»
0.0
Uncharacterized protein Phytophthora ramorum
TI:164328 None
 
H8WHB5_CAEBR
WormBase»
0.0
CBG24940 CBG_24940 Protein CBG24940 Caenorhabditis briggsae
TI:6238 None
 
H9GLP4_ANOCA
Ensembl»
0.0
Uncharacterized protein Anolis carolinensis
TI:28377 None
   
K7LCE6_SOYBN
EnsemblPlants»
0.0
100811574 Uncharacterized protein Glycine max
TI:3847 None
 
K7MCY9_SOYBN
EnsemblPlants»
0.0
100803883 Uncharacterized protein Glycine max
TI:3847 None
 
M1CR77_SOLTU
EnsemblPlants»
0.0
Nucleotide binding protein Solanum tuberosum
TI:4113 None
   
M3W0L6_FELCA
Ensembl»
0.0
DPH7 Diphthamide biosynthesis 7 Felis catus
TI:9685 None
 
Q0V1J0_PHANO
EnsemblFungi»
0.0
SNOG_02124 Anaphase-promoting complex subunit
4 WD40 domain-containing protein		 Phaeosphaeria nodorum
TI:13684 None
 
Q4WXC0_ASPFU
EnsemblFungi»
0.0
AFUA_3G08950 WD repeat protein Aspergillus fumigatus
TI:746128 None
 
Q587G9_TRYB2
VEuPathDB»
0.0
10C8.255 Uncharacterized protein Trypanosoma brucei
TI:5691 None
 
Q5B8W2_EMENI
EnsemblFungi»
0.0
ANIA_03018 Uncharacterized protein Emericella nidulans
TI:162425 None
 
Q5KNS3_CRYNJ
EnsemblFungi»
0.0
CNA05490 WD40 repeat domain 85 Cryptococcus neoformans
TI:5207 None
 
Q6C766_YARLI
EnsemblFungi»
0.0
YALI0_E03366g YALI0E03366p Yarrowia lipolytica
TI:4952 None
 
Q754V8_ASHGO
EnsemblFungi»
0.0
AGOS_AFL041C AFL041Cp Ashbya gossypii
TI:33169 None
 
Q7PR69_ANOGA
EnsemblMetazoa»
0.0
1273122 AGAP002839-PA (AGAP002839-PB) Anopheles gambiae
TI:7165 None
 
Q7X6X5_ORYSJ
EnsemblPlants»
0.0
Os04g0507900 Os04g0507900 protein (cDNA
clone:001-015-E04, full insert sequence)		 Oryza sativa
TI:4530 None
 
Q9FM51_ARATH
TAIR»
0.0
MJH22.7 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana
TI:3702 None
 
Q9W3X3_DROME
FlyBase»
2.0
Dmel\CG3184 GH14157p Drosophila melanogaster
TI:7227 None
 
T1G8U3_HELRO
EnsemblMetazoa»
0.0
20217490 Uncharacterized protein Helobdella robusta
TI:6412 None
 
U5D6W4_AMBTC
EnsemblPlants»
0.0
AMTR_s00044p00133320 Uncharacterized protein Amborella trichopoda
TI:13333 None 		 
 
U5D9U8_AMBTC
EnsemblPlants»
0.0
AMTR_s00044p00133430 Uncharacterized protein Amborella trichopoda
TI:13333 None 		 
   
V5IL10_NEUCR
EnsemblFungi»
0.0
NCU02388 WD40 repeat-like protein Neurospora crassa
TI:5141 None
 
W5M1M3_LEPOC
Ensembl»
0.0
Diphthamide biosynthesis 7 Lepisosteus oculatus
TI:7918 None