Collated Gene Ontology terms

Biological process: oxidoreductase activity(2007, 2009, 2022, 2024) ketoreductase activity(2007, 2017, 2024) testosterone 17-beta-dehydrogenase (NADP+) activity(2006, 2016, 2017, 2024) very-long-chain 3-oxoacyl-CoA reductase activity(2023, 2024) estradiol 17-beta-dehydrogenase [NAD(P)] activity(2005, 2024) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(2023, 2024) testosterone dehydrogenase [NAD(P)] activity(2024) heparin binding(2008, 2024) fibronectin binding(2008, 2024) collagen binding(2008, 2024)
acetoacetyl-CoA reductase activity2009, 2024 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity2024 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor2021, 2024 androstan-3-alpha,17-beta-diol dehydrogenase activity2021, 2024 17-beta-hydroxysteroid dehydrogenase (NADP+) activity2024 testosterone dehydrogenase (NAD+) activity2010 3-hydroxyacyl-CoA dehydrogenase activity2024

Molecular function: steroid biosynthetic process2007, 2010, 2017, 2024 fatty acid biosynthetic process2007, 2024 androgen biosynthetic process2006, 2024 fatty acid elongation, saturated fatty acid2023, 2024 estrogen biosynthetic process2024 positive regulation of cell-substrate adhesion2008, 2024 extracellular matrix organization2008, 2024 testosterone biosynthetic process2024 lipid metabolic process2024 very long-chain fatty acid biosynthetic process2009, 2024
multicellular organismal response to stress2014, 2024 embryo development ending in seed dormancy2014, 2024 secondary metabolite biosynthetic process2024 response to vitamin E2011 response to steroid hormone2010 response to organic cyclic compound2010 response to nutrient levels2010 response to metal ion2010 response to lead ion2007 response to insecticide2010 response to herbicide2010 response to fungicide2010 response to fatty acid2010 response to ethanol2010 response to estrogen2010 response to corticosterone2010 response to cadmium ion2010 response to arsenic-containing substance2010 response to activity2010 response to L-ascorbic acid2011 positive regulation of lipid storage2016 phenol-containing compound metabolic process2010 organic acid metabolic process2010 negative regulation of cell growth2016 male genitalia development2003 long-chain fatty-acyl-CoA biosynthetic process2024 insecticide metabolic process2010 hippocampus development2010 fatty acid elongation2018 cellular response to nutrient levels2016 cellular response to hormone stimulus2010 cellular response to gonadotropin stimulus2010 cellular response to antibiotic2010 biphenyl metabolic process2010 Leydig cell differentiation2010

Cellular component: endoplasmic reticulum2006, 2009, 2011, 2012, 2016, 2017, 2020, 2021, 2024 membrane2024 endoplasmic reticulum membrane2013, 2024 fatty acid elongase complex2020, 2024 chloroplast2024 extracellular matrix2018, 2024 mitochondrion2019, 2020 cytoplasm2017 mitochondrial inner membrane2009 intracellular membrane-bounded organelle2003
glycosome2015 cytosol2023

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 2/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 4/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 37/39 
Archea: 0/8 
Bacteria: 2/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 10 20 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
DHB3_MOUSE
Ensembl»
2.1
Hsd17b3 17-beta-hydroxysteroid dehydrogenase type 3 (17-beta-HSD 3) (Estradiol 17-beta-dehydrogenase 2)
(EC 1.1.1.62) (Testicular 17-beta-hydroxysteroid dehydrogenase) (Testosterone 17-beta-dehydrogenase 3) (EC 1.1.1.64)		 Mus musculus
TI:10090 None
 
DHB3_RAT
RGD»
26.1
Hsd17b3 17-beta-hydroxysteroid dehydrogenase type 3 (17-beta-HSD 3) (Estradiol 17-beta-dehydrogenase 2)
(EC 1.1.1.62) (Testicular 17-beta-hydroxysteroid dehydrogenase) (Testosterone 17-beta-dehydrogenase 3) (EC 1.1.1.64)		 Rattus norvegicus
TI:10116 None
 
DHB3_HUMAN
Ensembl»
4.5
HSD17B3 17-beta-hydroxysteroid dehydrogenase type 3 (17-beta-HSD 3) (Estradiol 17-beta-dehydrogenase 2) (EC 1.1.1.62) (Short chain
dehydrogenase/reductase family 12C member 2) (Testicular 17-beta-hydroxysteroid dehydrogenase) (Testosterone 17-beta-dehydrogenase 3) (EC 1.1.1.64)		 Homo sapiens
TI:9606 None
 
DHB3_DANRE
ZFIN»
2.1
hsd17b3 17-beta-hydroxysteroid dehydrogenase type 3 (17-beta-HSD 3) (Short chain dehydrogenase/reductase family
12C member 2) (Testicular 17-beta-hydroxysteroid dehydrogenase) (Testosterone 17-beta-dehydrogenase 3) (EC 1.1.1.64)		 Danio rerio
TI:7955 None
 
A2BFP6_DANRE
ZFIN»
2.9
hsd20b2 20beta-hydroxysteroid dehydrogenase type 2 (Hydroxysteroid
(20-beta) dehydrogenase 2) (Very-long-chain 3-oxoacyl-CoA reductase)		 Danio rerio
TI:7955 None
 
A0A8V0ZBE0_CHICK
Ensembl»
0.0
HSD17B12 Hydroxysteroid 17-beta dehydrogenase 12 Gallus gallus
TI:9031 None
   
A0A1L1RTH3_CHICK
Ensembl»
1.0
HSD17B3 Hydroxysteroid 17-beta dehydrogenase 3 Gallus gallus
TI:9031 None
   
Q9VJG8_DROME
FlyBase»
0.5
Dmel\CG6012 MIP25013p Drosophila melanogaster
TI:7227 None
 
Q8SX47_DROME
FlyBase»
0.5
Dmel\CG31810 RE06583p Drosophila melanogaster
TI:7227 None
 
Q8IGQ3_DROME
FlyBase»
0.5
Dmel\CG13284 RE48687p (Uncharacterized protein, isoform B
(EC 1.-.-.-)) (Uncharacterized protein, isoform D)		 Drosophila melanogaster
TI:7227 None
 
Q9W3N1_DROME
FlyBase»
3.4
spidey RH59310p (Spidey) Drosophila melanogaster
TI:7227 None
 
DHS5_CAEEL
WormBase»
0.5
dhs-5 Uncharacterized oxidoreductase dhs-5 (EC
1.-.-.-) (Short-chain dehydrogenase 5)		 Caenorhabditis elegans
TI:6239 None
 
Q54CD7_DICDI
dictyBase»
0.5
DDB_G0293034 Uncharacterized protein Dictyostelium discoideum
TI:44689 None
 
Q869Y3_DICDI
dictyBase»
0.5
DDB_G0275049 Uncharacterized protein Dictyostelium discoideum
TI:44689 None
 
Q8INZ8_DROME
FlyBase»
0.5
Dmel\CG31809 Uncharacterized protein, isoform B (Uncharacterized
protein, isoform C (EC 1.-.-.-))		 Drosophila melanogaster
TI:7227 None
 
DHB12_MOUSE
Ensembl»
4.0
Hsd17b12 Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330) (17-beta-hydroxysteroid dehydrogenase 12) (17-beta-HSD
12) (3-ketoacyl-CoA reductase) (KAR) (Estradiol 17-beta-dehydrogenase 12) (EC 1.1.1.62) (KIK-I)		 Mus musculus
TI:10090 None
 
DHB12_RAT
RGD»
4.0
Hsd17b12 Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330) (17-beta-hydroxysteroid dehydrogenase 12) (17-beta-HSD
12) (3-ketoacyl-CoA reductase) (KAR) (Estradiol 17-beta-dehydrogenase 12) (EC 1.1.1.62)		 Rattus norvegicus
TI:10116 None
 
DHB12_HUMAN
Ensembl»
3.8
HSD17B12 Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330) (17-beta-hydroxysteroid dehydrogenase 12) (17-beta-HSD 12) (3-ketoacyl-CoA reductase)
(KAR) (Estradiol 17-beta-dehydrogenase 12) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 12C member 1)		 Homo sapiens
TI:9606 None
 
KCR1_ARATH
TAIR»
3.2
KCR1 Very-long-chain 3-oxoacyl-CoA reductase 1 (EC 1.1.1.330) (Beta-ketoacyl
reductase 1) (AtKCR1) (Protein GLOSSY 8) (gl8At)		 Arabidopsis thaliana
TI:3702 None
 
DH12A_DANRE
ZFIN»
0.5
hsd17b12a Very-long-chain 3-oxoacyl-CoA reductase-A (EC 1.1.1.330) (17-beta-hydroxysteroid dehydrogenase 12-A) (17-beta-HSD 12-A)
(zf3.1) (zfHSD17B12A) (3-ketoacyl-CoA reductase) (KAR) (Estradiol 17-beta-dehydrogenase 12-A) (EC 1.1.1.62)		 Danio rerio
TI:7955 None
 
DH12B_DANRE
ZFIN»
0.5
hsd17b12b Very-long-chain 3-oxoacyl-CoA reductase-B (EC 1.1.1.330) (17-beta-hydroxysteroid dehydrogenase 12-B) (17-beta-HSD 12-B)
(zf3.3) (zfHSD17B12B) (3-ketoacyl-CoA reductase) (KAR) (Estradiol 17-beta-dehydrogenase 12-B) (EC 1.1.1.62)		 Danio rerio
TI:7955 None
 
KCR2_ARATH
TAIR»
1.6
KCR2 Very-long-chain 3-oxoacyl-CoA reductase-like protein At1g24470
(EC 1.-.-.-) (Beta-ketoacyl reductase 2) (AtKCR2)		 Arabidopsis thaliana
TI:3702 None