Collated Gene Ontology terms

Biological process: ferrochelatase activity(2003, 2005, 2006, 2007, 2009, 2010, 2011, 2014, 2019, 2023, 2024) lyase activity(2024) metal ion binding(2024) 2 iron, 2 sulfur cluster binding(2010, 2016, 2024) tetrapyrrole binding(2009, 2024) protein homodimerization activity(2021, 2024) iron-responsive element binding(2009, 2024) iron ion binding(2009, 2024) identical protein binding(2024) heme binding(2009, 2024)
phosphoribosyl-AMP cyclohydrolase activity2024 hydrolase activity2024 ferrous iron binding2003 cytoskeletal motor activity2024 ATP binding2024

Molecular function: heme biosynthetic process2003, 2005, 2009, 2010, 2013, 2014, 2017, 2019, 2021, 2023, 2024 protoporphyrinogen IX metabolic process2008, 2009, 2010, 2024 response to light stimulus2003, 2009, 2010, 2024 porphyrin-containing compound biosynthetic process2003, 2017, 2024 very-low-density lipoprotein particle assembly2009, 2024 regulation of hemoglobin biosynthetic process2009, 2024 multicellular organismal-level iron ion homeostasis2009, 2024 heme O biosynthetic process2023, 2024 heme B biosynthetic process2023, 2024 heme A biosynthetic process2023, 2024
erythrocyte differentiation2009, 2024 detection of UV2003, 2024 cholesterol metabolic process2009, 2024 tetrapyrrole biosynthetic process2009, 2017, 2024 response to xenobiotic stimulus2010, 2024 response to platinum ion2010, 2024 response to oxidative stress2007, 2024 response to methylmercury2010, 2024 response to metal ion2010, 2024 response to lead ion2010, 2024 response to insecticide2010, 2024 response to ethanol2010, 2024 response to arsenic-containing substance2010, 2024 histidine biosynthetic process2024 cellular response to dexamethasone stimulus2010, 2024 ubiquitin-dependent protein catabolic process2021 proteasome-mediated ubiquitin-dependent protein catabolic process2021 heme metabolic process2007 generation of precursor metabolites and energy2003 erythrocyte maturation2009

Cellular component: mitochondrion2009, 2014, 2018, 2023, 2024 chloroplast2009, 2024 mitochondrial inner membrane2003, 2004, 2019, 2023, 2024 membrane2024 cytoplasm2024 mitochondrial matrix2009, 2023, 2024 thylakoid2024 nucleus2009, 2024 chloroplast thylakoid membrane2024 chloroplast membrane2024
plastid thylakoid membrane2017 plastid2021 plasma membrane2010 myosin complex2024 cytosol2009

Phylogenetic distribution

Chordates: 20/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 13/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 1/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 37/39 
Archea: 0/8 
Bacteria: 28/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 5 10 15 20 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
HEMH2_ARATH
TAIR»
3.4
FC2 Ferrochelatase-2, chloroplastic (AtFC2) (EC 4.98.1.1) (Ferrochelatase-II)
(AtFC-II) (Heme synthase 2) (Protoheme ferro-lyase 2)		 Arabidopsis thaliana
TI:3702 None
 
HEMH1_ARATH
TAIR»
3.2
FC1 Ferrochelatase-1, chloroplastic/mitochondrial (AtFC1) (EC 4.98.1.1) (Ferrochelatase-I)
(AtFC-I) (Heme synthase 1) (Protoheme ferro-lyase 1)		 Arabidopsis thaliana
TI:3702 None
 
HEMH_CHICK
CTD»
2.0
FECH Ferrochelatase, mitochondrial (EC 4.98.1.1)
(Heme synthase) (Protoheme ferro-lyase)		 Gallus gallus
TI:9031 None
 
HEMH_DICDI
dictyBase»
2.0
hemH Ferrochelatase, mitochondrial (EC 4.98.1.1)
(Heme synthase) (Protoheme ferro-lyase)		 Dictyostelium discoideum
TI:44689 None
 
HEMH_DROME
FlyBase»
2.3
FeCh Ferrochelatase, mitochondrial (EC 4.98.1.1)
(Heme synthase) (Protoheme ferro-lyase)		 Drosophila melanogaster
TI:7227 None
 
HEMH_HUMAN
Ensembl»
9.5
FECH Ferrochelatase, mitochondrial (EC 4.98.1.1)
(Heme synthase) (Protoheme ferro-lyase)		 Homo sapiens
TI:9606 None
 
HEMH_MOUSE
Ensembl»
17.4
Fech Ferrochelatase, mitochondrial (EC 4.98.1.1)
(Heme synthase) (Protoheme ferro-lyase)		 Mus musculus
TI:10090 None
 
HEMH_SCHPO
PomBase»
1.8
hem15 Ferrochelatase, mitochondrial (EC 4.98.1.1)
(Heme synthase) (Protoheme ferro-lyase)		 Schizosaccharomyces pombe
TI:4896 None
 
HEMH_YEAST
SGD»
3.4
HEM15 Ferrochelatase, mitochondrial (EC 4.98.1.1)
(Heme synthase) (Protoheme ferro-lyase)		 Saccharomyces cerevisiae
TI:4932 None
 
A0A8M9PIE9_DANRE
CTD»
2.6
fech Ferrochelatase (EC 4.98.1.1) Danio rerio
TI:7955 None
   
A0A8V0Y318_CHICK
Ensembl»
0.0
FECH Ferrochelatase (EC 4.98.1.1) Gallus gallus
TI:9031 None
   
D3ZBM3_RAT
RGD»
20.7
Fech Ferrochelatase (EC 4.98.1.1) Rattus norvegicus
TI:10116 None
   
HEMH_ECOLI
EnsemblBacteria»
5.8
hemH Ferrochelatase (EC 4.98.1.1)
(Heme synthase) (Protoheme ferro-lyase)		 Escherichia coli
TI:562 None
 
G5EBW5_CAEEL
WormBase»
1.0
fecl-1 FErroChelatase-Like Caenorhabditis elegans
TI:6239 None