Collated Gene Ontology terms

Biological process: N6-threonylcarbomyladenosine methylthiotransferase activity(2012, 2013, 2017, 2024) 4 iron, 4 sulfur cluster binding(2024) metal ion binding(2024) tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase(2024) transferase activity(2024) methylthiotransferase activity(2024) catalytic activity(2024) iron-sulfur cluster binding(2024) oxidoreductase activity(2024) methyltransferase activity(2024)
antiporter activity2024 2-alkenal reductase [NAD(P)+] activity2024

Molecular function: tRNA methylthiolation2012, 2013, 2022, 2024 tRNA processing2024 tRNA modification2024 maintenance of translational fidelity2013, 2024 type B pancreatic cell development2017 transmembrane transport2024 pancreas regeneration2017 methylation2024 endocrine pancreas development2017

Cellular component: endoplasmic reticulum2013, 2017, 2021, 2024 membrane2014, 2024 endoplasmic reticulum membrane2015, 2024 rough endoplasmic reticulum2013, 2024 cytoplasm2024 mitochondrion2017 mitochondrial outer membrane2015 endomembrane system2014

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 2/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 1/3 
Excavates: 2/4 
Harosa: 1/4 
Hacrobia: 0/0 
Plants: 36/39 
Archea: 8/8 
Bacteria: 15/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
E1BRH0_CHICK
Ensembl»
1.0
CDKAL1 tRNA-t(6)A37 methylthiotransferase (EC 2.8.4.5) Gallus gallus
TI:9031 None
   
F1LV76_RAT
RGD»
1.5
Cdkal1 tRNA-t(6)A37 methylthiotransferase (EC 2.8.4.5) Rattus norvegicus
TI:10116 None
   
CDKAL_CAEEL
WormBase»
1.0
Y92H12BL.1 Threonylcarbamoyladenosine tRNA methylthiotransferase (EC
2.8.4.5) (CDKAL1-like protein) (tRNA-t(6)A37 methylthiotransferase)		 Caenorhabditis elegans
TI:6239 None
 
CDKAL_DANRE
ZFIN»
3.4
cdkal1 Threonylcarbamoyladenosine tRNA methylthiotransferase (EC 2.8.4.5) (CDK5
regulatory subunit-associated protein 1-like 1) (tRNA-t(6)A37 methylthiotransferase)		 Danio rerio
TI:7955 None
 
Q9BKW0_CAEEL
WormBase»
0.0
CELE_Y92H12BL.4 Y92H12BL.4 MTTase N-terminal domain-containing protein Caenorhabditis elegans
TI:6239 None
 
CDKAL_DROME
FlyBase»
1.0
CG6550 Threonylcarbamoyladenosine tRNA methylthiotransferase (EC
2.8.4.5) (CDKAL1-like protein) (tRNA-t(6)A37 methylthiotransferase)		 Drosophila melanogaster
TI:7227 None
 
Q9C7H2_ARATH
TAIR»
0.0
At1g72090 Threonylcarbamoyladenosine tRNA methylthiotransferase
(EC 2.8.4.5) (tRNA-t(6)A37 methylthiotransferase)		 Arabidopsis thaliana
TI:3702 None
 
CDKAL_HUMAN
Ensembl»
1.0
CDKAL1 Threonylcarbamoyladenosine tRNA methylthiotransferase (EC 2.8.4.5) (CDK5
regulatory subunit-associated protein 1-like 1) (tRNA-t(6)A37 methylthiotransferase)		 Homo sapiens
TI:9606 None
 
CDKAL_MOUSE
Ensembl»
2.4
Cdkal1 Threonylcarbamoyladenosine tRNA methylthiotransferase (EC 2.8.4.5) (CDK5
regulatory subunit-associated protein 1-like 1) (tRNA-t(6)A37 methylthiotransferase)		 Mus musculus
TI:10090 None