Collated Gene Ontology terms

Biological process: tryptophan-tRNA ligase activity(2005, 2013, 2014, 2016, 2023, 2025) ligase activity(2025) ATP binding(2004, 2025) nucleotide binding(2025) aminoacyl-tRNA ligase activity(2025) transferase activity(2025) zinc ion binding(2025) metal ion binding(2025) isoleucine-tRNA ligase activity(2025)

Molecular function: tryptophanyl-tRNA aminoacylation2005, 2014, 2016, 2023, 2025 tRNA aminoacylation for protein translation2023, 2025 translation2025 mitochondrial tryptophanyl-tRNA aminoacylation2013, 2017, 2024, 2025 reproductive structure development2025 post-embryonic development2025 positive regulation of angiogenesis2025 vasculogenesis2006 protein transport2025 plant ovule development2005

Cellular component: mitochondrion2005, 2009, 2013, 2016, 2018, 2023, 2024, 2025 mitochondrial matrix2013, 2017, 2025 chloroplast2005, 2017, 2018, 2021, 2025 cytoplasm2025 cytosol2014, 2024, 2025 plasma membrane2010, 2025 vacuole2019 peroxisomal membrane2025 nucleoplasm2025 chloroplast stroma2021

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 14/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 0/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 37/39 
Archea: 0/8 
Bacteria: 35/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
SYWM_HUMAN
Ensembl»
3.6
WARS2 Tryptophan--tRNA ligase, mitochondrial (EC
6.1.1.2) ((Mt)TrpRS) (Tryptophanyl-tRNA synthetase) (TrpRS)		 Homo sapiens
TI:9606 None
 
SYW_ECOLI
EnsemblBacteria»
2.6
trpS Tryptophan--tRNA ligase (EC
6.1.1.2) (Tryptophanyl-tRNA synthetase) (TrpRS)		 Escherichia coli
TI:562 None
 
Q9VVL8_DROME
FlyBase»
3.3
TrpRS-m Tryptophan--tRNA ligase, mitochondrial (EC
6.1.1.2) ((Mt)TrpRS) (Tryptophanyl-tRNA synthetase)		 Drosophila melanogaster
TI:7227 None
 
SYWM_ARATH
TAIR»
1.8
OVA4 Tryptophan--tRNA ligase, chloroplastic/mitochondrial (EC 6.1.1.2) (Protein
OVULE ABORTION 4) (Tryptophanyl-tRNA synthetase) (TrpRS)		 Arabidopsis thaliana
TI:3702 None
 
SYWM_MOUSE
Ensembl»
3.3
Wars2 Tryptophan--tRNA ligase, mitochondrial (EC
6.1.1.2) ((Mt)TrpRS) (Tryptophanyl-tRNA synthetase) (TrpRS)		 Mus musculus
TI:10090 None
 
SYWM_YEAST
SGD»
3.1
MSW1 Tryptophan--tRNA ligase, mitochondrial (EC
6.1.1.2) (Tryptophanyl-tRNA synthetase) (TrpRS)		 Saccharomyces cerevisiae
TI:4932 None
 
SYWM_CAEEL
WormBase»
1.0
prx-10 Tryptophan--tRNA ligase, mitochondrial (EC
6.1.1.2) (Tryptophanyl-tRNA synthetase) (TrpRS)		 Caenorhabditis elegans
TI:6239 None
 
SYWM_DICDI
dictyBase»
2.0
wars2 Tryptophan--tRNA ligase, mitochondrial (EC
6.1.1.2) (Tryptophanyl-tRNA synthetase) (TrpRS)		 Dictyostelium discoideum
TI:44689 None
 
SYWM_SCHPO
PomBase»
2.5
msw1 Tryptophan--tRNA ligase, mitochondrial (EC
6.1.1.2) (Tryptophanyl-tRNA synthetase) (TrpRS)		 Schizosaccharomyces pombe
TI:4896 None
 
A0A8V1A0A7_CHICK
Ensembl»
1.0
LOC101750690 Tryptophan--tRNA ligase, mitochondrial (EC
6.1.1.2) ((Mt)TrpRS) (Tryptophanyl-tRNA synthetase)		 Gallus gallus
TI:9031 None
   
A0ABK0M2U4_RAT
RGD»
0.0
Wars2 tryptophan--tRNA ligase (EC
6.1.1.2) (Tryptophanyl-tRNA synthetase)		 Rattus norvegicus
TI:10116 None