Collated Gene Ontology terms

Biological process: ubiquitin protein ligase activity(2015, 2025) zinc ion binding(2025) metal ion binding(2025) transferase activity(2025) molecular sequestering activity(2023, 2024, 2025) RNA binding(2014, 2015, 2025) ubiquitin-protein transferase activity(2025) peptidyl-prolyl cis-trans isomerase activity(2025) ligase activity(2025) isomerase activity(2025)

Molecular function: regulation of nitric oxide biosynthetic process2023, 2025 protein ubiquitination2024, 2025 negative regulation of nitric-oxide synthase activity2007, 2025 negative regulation of catalytic activity2007, 2025 protein destabilization2015 photomorphogenesis2015 nitric oxide metabolic process2025 mRNA splicing, via spliceosome2010

Cellular component: nucleus2007, 2008, 2018, 2020, 2025 cytoplasm2007, 2025 nucleoplasm2024, 2025 nuclear speck2015, 2025 cytosol2013 catalytic step 2 spliceosome2010 Golgi membrane2013

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 2/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 9/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 1/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 39/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A2I2ZH49_GORGO
Ensembl»
0.0
NOSIP Nitric oxide synthase-interacting protein Gorilla gorilla
TI:9593 None
 
CSU1_ARATH
TAIR»
2.9
CSU1 E3 ubiquitin-protein ligase CSU1 (EC 2.3.2.27) (Protein
COP1 SUPPRESSOR 1) (RING-type E3 ubiquitin transferase CSU1)		 Arabidopsis thaliana
TI:3702 None
 
B7PFR6_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW017590 Nitric oxide
synthase-interacting protein homolog		 Ixodes scapularis
TI:6945 None
 
NOSIP_HUMAN
Ensembl»
6.8
NOSIP Nitric oxide synthase-interacting protein (E3 ubiquitin-protein ligase NOSIP)
(EC 2.3.2.27) (RING-type E3 ubiquitin transferase NOSIP) (eNOS-interacting protein)		 Homo sapiens
TI:9606 None
 
B4FLI7_MAIZE
EnsemblPlants»
0.0
LOC100280875 Nitric oxide synthase
interacting protein (Phosphoinositide binding)		 Zea mays
TI:4577 None
 
I3S8Y8_MEDTR
EnsemblPlants»
0.0
25485902 Nitric oxide synthase interacting protein
(Putative nitric oxide synthase-interacting protein, zinc-finger)		 Medicago truncatula
TI:3880 None
 
M4ERJ4_BRACM
EnsemblPlants»
0.0
BRAA01T03171Z BRAPAZ1V2_A01P33290.2 BRARA_A02551 RING-type domain-containing protein Brassica campestris
TI:3711 None
 
NOSIP_MOUSE
Ensembl»
2.5
Nosip Nitric oxide synthase-interacting protein (E3 ubiquitin-protein ligase
NOSIP) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase NOSIP)		 Mus musculus
TI:10090 None
 
A0A251T0Z9_HELAN
euHCVdb»
0.0
HannXRQ_Chr12g0359441 HanXRQr2_Chr12g0527301 Nitric oxide synthase-interacting protein
(Putative phosphoinositide binding protein)		 Helianthus annuus
TI:4232 None
 
A0A251TR36_HELAN
neXtProt»
0.0
HannXRQ_Chr10g0310231 HanXRQr2_Chr10g0456541 Putative nitric oxide synthase-interacting, Nitric oxide
synthase-interacting protein, zinc-finger (Transcription factor C2H2 family)		 Helianthus annuus
TI:4232 None
 
B4FMP2_MAIZE
EnsemblPlants»
0.0
LOC100282877 Phosphoinositide binding Zea mays
TI:4577 None
 
D8RPB2_SELML
euHCVdb»
0.0
SELMODRAFT_120430 SELMODRAFT_98131 RING-type domain-containing protein Selaginella moellendorffii
TI:88036 None
 
K4AD21_SETIT
EnsemblPlants»
0.0
LOC101773785 RING-type domain-containing protein Setaria italica
TI:4555 None
 
K7VJD6_MAIZE
EnsemblPlants»
0.0
LOC103639297 Phosphoinositide binding Zea mays
TI:4577 None
 
Q10N73_ORYSJ
euHCVdb»
0.0
LOC_Os03g17170 Os03g0279900 Os03g0279900 protein (Zinc finger,
C3HC4 type family protein, expressed)		 Oryza sativa
TI:4530 None
 
T1ENQ8_HELRO
EnsemblMetazoa»
0.0
20198208 Nitric oxide synthase-interacting protein (EC 2.3.2.27) (E3
ubiquitin-protein ligase NOSIP) (RING-type E3 ubiquitin transferase NOSIP)		 Helobdella robusta
TI:6412 None
 
T1FWJ3_HELRO
EnsemblMetazoa»
0.0
20213188 UBA domain-containing protein Helobdella robusta
TI:6412 None
 
A0A022QN28_ERYGU
euHCVdb»
0.0
MIMGU_mgv1a010723mg RING-type domain-containing protein Erythranthe guttata
TI:4155 None
 
A0A022R1Y9_ERYGU
euHCVdb»
0.0
MIMGU_mgv1a011329mg RING-type domain-containing protein Erythranthe guttata
TI:4155 None
 
A0A061GH28_THECC
euHCVdb»
0.0
TCM_030022 Phosphoinositide binding Theobroma cacao
TI:3641 None
 
A0A067G7U2_CITSI
euHCVdb»
0.0
CISIN_1g0220292mg Nitric oxide synthase-interacting
protein zinc-finger domain-containing protein		 Citrus sinensis
TI:2711 None
 
A0A067G7Z5_CITSI
neXtProt»
0.0
CISIN_1g0220291mg RING-type domain-containing protein Citrus sinensis
TI:2711 None
 
A0A078ID52_BRANA
euHCVdb»
0.0
BnaC01g43380D BnaC01g43380D protein Brassica napus
TI:3708 None
 
A0A078IGC2_BRANA
euHCVdb»
0.0
BnaA01g22770D BnaA01g22770D protein Brassica napus
TI:3708 None
 
A0A0A0K5A3_CUCSA
neXtProt»
0.0
Csa_7G195280 RING-type domain-containing protein Cucumis sativus
TI:3659 None
 
A0A0A0KF19_CUCSA
euHCVdb»
0.0
Csa_6G087940 RING-type domain-containing protein Cucumis sativus
TI:3659 None
 
A0A0K9PRE2_ZOSMR
neXtProt»
0.0
ZOSMA_179G00350 RING-type domain-containing protein Zostera marina
TI:29655 None
 
A0A0P0VUB1_ORYSJ
neXtProt»
0.0
Os03g0201100 RING-type E3 ubiquitin transferase (EC 2.3.2.27) Oryza sativa
TI:4530 None
 
A0A1D6PDF7_MAIZE
EnsemblPlants»
0.0
LOC103639301 Phosphoinositide binding Zea mays
TI:4577 None
 
A0A1U8FMR3_CAPAN
euHCVdb»
0.0
T459_05784 RING-type domain-containing protein Capsicum annuum
TI:4072 None
 
A0A1Y1HYP3_KLENI
neXtProt»
0.0
KFL_000990100 RING-type domain-containing protein Klebsormidium nitens
TI:105231 None
 
A0A2C9U5C6_MANES
euHCVdb»
0.0
MANES_17G032800v8 RING-type domain-containing protein Manihot esculenta
TI:3983 None
 
A0A2R6X8Z1_MARPO
euHCVdb»
0.0
MARPO_0029s0083 RING-type domain-containing protein Marchantia polymorpha
TI:3197 None
 
A0A7U2FF42_PHANO
TubercuList»
0.0
JI435_128580 RING-type domain-containing protein Phaeosphaeria nodorum
TI:13684 None
 
A0A804HQ13_MUSAM
EnsemblPlants»
0.0
GSMUA_287800.1 (wild Malaysian banana) hypothetical protein Musa acuminata
TI:4641 None
 
A0A9K3N5Z2_HELAN
euHCVdb»
0.0
HanXRQr2_Chr10g0456521 Transcription factor C2H2 family Helianthus annuus
TI:4232 None
 
A0A9R1VGS7_LACSA
euHCVdb»
0.0
LSAT_V11C500257170 RING-type domain-containing protein Lactuca sativa
TI:4236 None
 
A0DSS8_PARTE
neXtProt»
0.0
GSPATT00019788001 RING-type domain-containing protein Paramecium tetraurelia
TI:5888 None
 
A2EL07_TRIV3
TubercuList»
0.0
TVAG_322550 RING-type domain-containing protein Trichomonas vaginalis
TI:5722 None
 
A7F7X7_SCLS1
TubercuList»
0.0
SS1G_13707 RING-type domain-containing protein Sclerotinia sclerotiorum
TI:5180 None
 
A7S885_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g243516 U-box domain-containing protein Nematostella vectensis
TI:45351 None
 
A8JDK0_CHLRE
euHCVdb»
0.0
CHLRE_02g142086v5 Nitric oxide synthase-interacting
protein zinc-finger domain-containing protein		 Chlamydomonas reinhardtii
TI:3055 None
 
A8X1D9_CAEBR
WormBase»
0.0
CBG05897 CBG_05897 Nitric oxide
synthase-interacting protein homolog		 Caenorhabditis briggsae
TI:6238 None
 
A9TFK2_PHYPA
EnsemblPlants»
0.0
LOC112287116 RING-type domain-containing protein Physcomitrium patens
TI:3218 None
 
A9TLF0_PHYPA
EnsemblPlants»
0.0
LOC112291989 RING-type domain-containing protein Physcomitrium patens
TI:3218 None
 
A9UWF5_MONBE
neXtProt»
0.0
MONBRDRAFT_18592 Nitric oxide synthase-interacting
protein zinc-finger domain-containing protein		 Monosiga brevicollis
TI:81824 None
 
B3RT40_TRIAD
CTD»
0.0
TRIADDRAFT_22121 Nitric oxide synthase-interacting
protein zinc-finger domain-containing protein		 Trichoplax adhaerens
TI:10228 None
 
B4FMT6_MAIZE
EnsemblPlants»
0.0
LOC100272289 RING-type domain-containing protein Zea mays
TI:4577 None
 
B8BYP6_THAPS
neXtProt»
0.0
THAPSDRAFT_21910 Nitric oxide synthase-interacting
protein zinc-finger domain-containing protein		 Thalassiosira pseudonana
TI:35128 None
 
B9HYP8_POPTR
neXtProt»
0.0
POPTR_011G040000 RING-type domain-containing protein Populus trichocarpa
TI:3694 None
 
B9P5E3_POPTR
neXtProt»
0.0
POPTR_004G026800 RING-type domain-containing protein Populus trichocarpa
TI:3694 None
 
B9SFE5_RICCO
euHCVdb»
0.0
RCOM_1096770 Ubiquitin-protein ligase, putative Ricinus communis
TI:3988 None
 
C0H4E6_PLAF7
TubercuList»
0.0
PF3D7_0518000 NOSIP domain-containing protein, putative Plasmodium falciparum
TI:5833 None
 
C5WPB0_SORBI
euHCVdb»
0.0
SORBI_3001G415500 RING-type domain-containing protein Sorghum bicolor
TI:4558 None
 
D6WHA6_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_03909 Nitric oxide
synthase-interacting protein homolog		 Tribolium castaneum
TI:7070 None
 
E3KV94_PUCGT
TubercuList»
0.0
PGTG_14273 RING-type domain-containing protein Puccinia graminis
TI:5297 None
 
E9G2C9_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_308434 Nitric oxide
synthase-interacting protein homolog		 Daphnia pulex
TI:6669 None
 
F0ZMH5_DICPU
TubercuList»
0.0
DICPUDRAFT_152871 Nitric oxide
synthase-interacting protein homolog		 Dictyostelium purpureum
TI:5786 None
 
F2E3B3_HORVV
EnsemblPlants»
0.0
LOC123448986 Predicted protein Hordeum vulgare
TI:4513 None
 
F4PBD7_BATDJ
euHCVdb»
0.0
BATDEDRAFT_91813 Nitric oxide synthase-interacting
protein zinc-finger domain-containing protein		 Batrachochytrium dendrobatidis
TI:109871 None
 
F6I745_VITVI
neXtProt»
0.0
VIT_00s0203g00190 RING-type domain-containing protein Vitis vinifera
TI:29760 None
 
H2QGV5_PANTR
Ensembl»
0.0
NOSIP Nitric oxide synthase-interacting protein Pan troglodytes
TI:9598 None
 
H3GX10_PHYRM
EnsemblProtists»
0.0
Nitric oxide synthase-interacting
protein zinc-finger domain-containing protein		 Phytophthora ramorum
TI:164328 None
 
I1H6V1_BRADI
EnsemblPlants»
0.0
LOC100822269 RING-type domain-containing protein Brachypodium distachyon
TI:15368 None
 
I1M2E0_SOYBN
EnsemblPlants»
0.0
LOC100786703 RING-type domain-containing protein Glycine max
TI:3847 None
 
I1ME85_SOYBN
EnsemblPlants»
0.0
LOC100806356 RING-type domain-containing protein Glycine max
TI:3847 None
 
K7W0M4_MAIZE
EnsemblPlants»
0.0
LOC103639300 Phosphoinositide binding Zea mays
TI:4577 None
 
M5WGG6_PRUPE
euHCVdb»
0.0
PRUPE_4G033800 Uncharacterized protein Prunus persica
TI:3760 None
 
NOSIP_BOVIN
Ensembl»
0.0
NOSIP Nitric oxide synthase-interacting protein (E3 ubiquitin-protein ligase
NOSIP) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase NOSIP)		 Bos taurus
TI:9913 None
 
NOSIP_CAEEL
WormBase»
0.5
R05G6.4 Nitric oxide
synthase-interacting protein homolog		 Caenorhabditis elegans
TI:6239 None
 
NOSIP_DANRE
ZFIN»
0.5
nosip Nitric oxide synthase-interacting protein (E3 ubiquitin-protein ligase
NOSIP) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase NOSIP)		 Danio rerio
TI:7955 None
 
NOSIP_DICDI
dictyBase»
2.8
nosip Nitric oxide
synthase-interacting protein homolog		 Dictyostelium discoideum
TI:44689 None
 
NOSIP_DROME
FlyBase»
3.0
CG6179 Nitric oxide
synthase-interacting protein homolog		 Drosophila melanogaster
TI:7227 None
 
NOSIP_XENLA
Xenbase»
0.0
nosip Nitric oxide synthase-interacting protein (E3 ubiquitin-protein ligase
NOSIP) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase NOSIP)		 Xenopus laevis
TI:8355 None
 
NOSIP_XENTR
Xenbase»
0.0
nosip Nitric oxide synthase-interacting protein (E3 ubiquitin-protein ligase
NOSIP) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase NOSIP)		 Xenopus tropicalis
TI:8364 None
 
Q4X1U3_ASPFU
TubercuList»
0.0
AFUA_2G08770 RING finger domain protein, putative Aspergillus fumigatus
TI:746128 None
 
Q5BB96_EMENI
TubercuList»
0.0
ANIA_02184 RING finger domain
protein, putative (AFU_orthologue AFUA_2G08770)		 Emericella nidulans
TI:162425 None
 
Q5KIS8_CRYD1
TubercuList»
0.0
CND01890 Zinc finger RING-type
eukaryotic domain-containing protein		 Cryptococcus deneoformans
TI:40410 None
 
Q7Q6V1_ANOGA
EnsemblMetazoa»
0.0
1276338 Nitric oxide
synthase-interacting protein homolog		 Anopheles gambiae
TI:7165 None
 
Q7S115_NEUCR
TubercuList»
0.0
NCU07577 Zinc finger containing protein Neurospora crassa
TI:5141 None
 
Q8I2K8_PLAF7
TubercuList»
0.0
PF3D7_0930600.1 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Plasmodium falciparum
TI:5833 None
 
W1NP95_AMBTC
euHCVdb»
0.0
AMTR_s00072p00050030 RING-type domain-containing protein Amborella trichopoda
TI:13333 None
 
W1NTE0_AMBTC
neXtProt»
0.0
AMTR_s00072p00049060 Nitric oxide synthase-interacting
protein zinc-finger domain-containing protein		 Amborella trichopoda
TI:13333 None
 
W5NKR6_LEPOC
Ensembl»
0.0
Nitric oxide synthase-interacting protein Lepisosteus oculatus
TI:7918 None
 
A0A1D5RG47_MACMU
Ensembl»
0.0
NOSIP Nitric oxide synthase-interacting protein Macaca mulatta
TI:9544 None
   
A0A1L8FGZ1_XENLA
Xenbase»
0.0
nosip.S Nitric oxide synthase-interacting protein Xenopus laevis
TI:8355 None
   
A0A1S3ZU30_TOBAC
euHCVdb»
0.0
LOC107790508 E3 ubiquitin-protein ligase CSU1-like
(Nitric oxide synthase-interacting protein-like)		 Nicotiana tabacum
TI:4097 None
   
A0A1S4CXU2_TOBAC
euHCVdb»
0.0
LOC107823767 E3 ubiquitin-protein ligase CSU1
(Nitric oxide synthase-interacting protein)		 Nicotiana tabacum
TI:4097 None
   
A0A1U8B089_NELNU
euHCVdb»
0.0
LOC104605727 Nitric oxide synthase-interacting protein Nelumbo nucifera
TI:4432 None
   
A0A1U8LDZ2_GOSHI
euHCVdb»
0.0
LOC107925252 E3 ubiquitin-protein ligase CSU1 Gossypium hirsutum
TI:3635 None
   
A0A1U8MWL5_GOSHI
euHCVdb»
0.0
LOC107942073 E3 ubiquitin-protein ligase CSU1 Gossypium hirsutum
TI:3635 None
   
A0A3B3HXD4_ORYLA
Ensembl»
0.0
NOSIP Nitric oxide synthase-interacting protein Oryzias latipes
TI:8090 None
   
A0A3B6HTL1_WHEAT
EnsemblPlants»
0.0
LOC123085484 Nitric oxide
synthase-interacting protein homolog		 Triticum aestivum
TI:4565 None
   
A0A3B6IS78_WHEAT
EnsemblPlants»
0.0
LOC123092560 Nitric oxide
synthase-interacting protein homolog		 Triticum aestivum
TI:4565 None
   
A0A3B6JIM7_WHEAT
EnsemblPlants»
0.0
LOC123097863 Nitric oxide
synthase-interacting protein homolog		 Triticum aestivum
TI:4565 None
   
A0A3Q7FRI4_SOLLC
EnsemblPlants»
0.0
LOC101247881 Nitric oxide
synthase-interacting protein homolog		 Solanum lycopersicum
TI:4081 None
   
A0A5G2QVZ0_PIG
Ensembl»
0.0
NOSIP Nitric oxide synthase-interacting protein Sus scrofa
TI:9823 None
   
A0A6I8PH58_ORNAN
Ensembl»
0.0
NOSIP Nitric oxide synthase-interacting protein Ornithorhynchus anatinus
TI:9258 None
   
A0A6P9ES43_JUGRE
neXtProt»
0.0
LOC108981398 E3 ubiquitin-protein ligase CSU1 Juglans regia
TI:51240 None
   
A0A7M7RCW6_STRPU
EnsemblMetazoa»
0.0
Nitric oxide synthase-interacting
protein zinc-finger domain-containing protein		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A803SRD6_ANOCA
Ensembl»
0.0
NOSIP Nitric oxide synthase-interacting protein Anolis carolinensis
TI:28377 None
   
A0A804L500_MUSAM
EnsemblPlants»
0.0
Nitric oxide synthase-interacting
protein zinc-finger domain-containing protein		 Musa acuminata
TI:4641 None
   
A0A8I3PPA2_CANLF
Ensembl»
0.0
NOSIP Nitric oxide synthase-interacting protein (EC 2.3.2.27) (E3
ubiquitin-protein ligase NOSIP) (RING-type E3 ubiquitin transferase NOSIP)		 Canis lupus
TI:9612 None
   
A0A9J7MP10_BRAFL
euHCVdb»
0.0
LOC118414340 Nitric oxide synthase-interacting protein (E3 ubiquitin-protein
ligase NOSIP) (RING-type E3 ubiquitin transferase NOSIP)		 Branchiostoma floridae
TI:7739 None
   
A0A9L0S3N2_HORSE
Ensembl»
0.0
Nitric oxide synthase-interacting
protein zinc-finger domain-containing protein		 Equus caballus
TI:9796 None
   
A0A9L0SNA4_HORSE
Ensembl»
0.0
NOSIP Nitric oxide synthase-interacting protein Equus caballus
TI:9796 None
   
A0A9L0TRJ4_HORSE
Ensembl»
0.0
Nitric oxide synthase-interacting
protein zinc-finger domain-containing protein		 Equus caballus
TI:9796 None
   
A0A9R0II52_SPIOL
euHCVdb»
0.0
LOC110789189 E3 ubiquitin-protein ligase CSU1 Spinacia oleracea
TI:3562 None
   
A0ABI7ZPB0_FELCA
Ensembl»
0.0
NOSIP Nitric oxide synthase-interacting protein Felis catus
TI:9685 None
   
D3ZH12_RAT
RGD»
2.0
Nosip Nitric oxide synthase-interacting protein Rattus norvegicus
TI:10116 None
   
F6UWQ9_MONDO
Ensembl»
0.0
NOSIP Nitric oxide synthase-interacting protein Monodelphis domestica
TI:13616 None
   
F6YQB2_CIOIN
Ensembl»
0.0
LOC100180053 Nitric oxide synthase-interacting protein (E3 ubiquitin-protein
ligase NOSIP) (RING-type E3 ubiquitin transferase NOSIP)		 Ciona intestinalis
TI:7719 None
   
M1C192_SOLTU
EnsemblPlants»
0.0
LOC102602935 RING-type domain-containing protein Solanum tuberosum
TI:4113 None