Collated Gene Ontology terms

Biological process: 2-(3-amino-3-carboxypropyl)histidine synthase activity(2021, 2022, 2024, 2025) metal ion binding(2025) iron-sulfur cluster binding(2025) transferase activity(2025) 4 iron, 4 sulfur cluster binding(2022, 2025) ligase activity(2025) diphthine-ammonia ligase activity(2025) carboxylic ester hydrolase activity(2025) carboxylesterase activity(2025)

Molecular function: protein histidyl modification to diphthamide2013, 2014, 2022, 2023, 2024, 2025 response to oxidative stress2025 regulation of translational fidelity2024, 2025 maintenance of translational fidelity2024, 2025 regulation of cytoplasmic translation2009 cell population proliferation2004

Cellular component: 2-(3-amino-3-carboxypropyl)histidine synthase complex2024, 2025 cytosol2009, 2014, 2022, 2023, 2024, 2025 cytoplasm2014, 2017, 2018, 2025 perinuclear region of cytoplasm2024, 2025 protein-containing complex2024, 2025 nucleoplasm2024, 2025 nucleus2009, 2025 ciliary plasm2017 cell junction2025

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 15/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 3/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 39/39 
Archea: 6/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
A0A0G2K269_RAT
RGD»
1.5
Dph1 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (EC 2.5.1.108) (Diphthamide biosynthesis protein
1) (Diphtheria toxin resistance protein 1) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1)		 Rattus norvegicus
TI:10116 None
   
A0A8V0ZCB3_CHICK
Ensembl»
0.5
DPH2 2-(3-amino-3-carboxypropyl)histidine synthase
subunit 2		 Gallus gallus
TI:9031 None
   
A0A8V1AM15_CHICK
Ensembl»
0.5
DPH1 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (EC 2.5.1.108) (Diphthamide biosynthesis protein
1) (Diphtheria toxin resistance protein 1) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1)		 Gallus gallus
TI:9031 None
   
DPH1_CAEEL
WormBase»
2.0
dph-1 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (EC 2.5.1.108) (Diphthamide biosynthesis protein
1) (Diphtheria toxin resistance protein 1) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1)		 Caenorhabditis elegans
TI:6239 None
 
DPH1_CHICK
TubercuList»
2.0
DPH1 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (EC 2.5.1.108) (Diphthamide biosynthesis protein
1) (Diphtheria toxin resistance protein 1) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1)		 Gallus gallus
TI:9031 None
 
DPH1_DANRE
ZFIN»
2.0
dph1 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (EC 2.5.1.108) (Diphthamide biosynthesis protein
1) (Diphtheria toxin resistance protein 1) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1)		 Danio rerio
TI:7955 None
 
DPH1_DICDI
dictyBase»
2.0
dph1 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (EC 2.5.1.108) (Diphthamide biosynthesis protein
1) (Diphtheria toxin resistance protein 1) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1)		 Dictyostelium discoideum
TI:44689 None
 
DPH1_HUMAN
Ensembl»
2.6
DPH1 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (EC 2.5.1.108) (Diphthamide biosynthesis protein 1) (Diphtheria
toxin resistance protein 1) (Ovarian cancer-associated gene 1 protein) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1)		 Homo sapiens
TI:9606 None
 
DPH1_MOUSE
Ensembl»
6.0
Dph1 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (EC 2.5.1.108) (Diphthamide biosynthesis protein 1) (Diphtheria toxin
resistance protein 1) (Ovarian cancer-associated gene 1 protein homolog) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1)		 Mus musculus
TI:10090 None
 
DPH1_SCHPO
PomBase»
3.0
dph1 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (EC 2.5.1.108) (Diphthamide biosynthesis protein
1) (Diphtheria toxin resistance protein 1) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1)		 Schizosaccharomyces pombe
TI:4896 None
 
DPH1_YEAST
SGD»
4.5
DPH1 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (EC 2.5.1.108) (Diphthamide biosynthesis protein
1) (Diphtheria toxin resistance protein 1) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1)		 Saccharomyces cerevisiae
TI:4932 None
 
DPH2_CAEEL
WormBase»
2.0
dph-2 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (Diphthamide biosynthesis protein 2)
(Diphtheria toxin resistance protein 2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2)		 Caenorhabditis elegans
TI:6239 None
 
DPH2_CHICK
CTD»
2.0
DPH2 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (Diphthamide biosynthesis protein 2)
(Diphtheria toxin resistance protein 2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2)		 Gallus gallus
TI:9031 None
 
DPH2_DANRE
ZFIN»
2.0
dph2 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (Diphthamide biosynthesis protein 2)
(Diphtheria toxin resistance protein 2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2)		 Danio rerio
TI:7955 None
 
DPH2_DICDI
dictyBase»
2.0
dph2 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (Diphthamide biosynthesis protein 2)
(Diphtheria toxin resistance protein 2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2)		 Dictyostelium discoideum
TI:44689 None
 
DPH2_HUMAN
Ensembl»
5.1
DPH2 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (Diphthamide biosynthesis protein 2)
(Diphtheria toxin resistance protein 2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2)		 Homo sapiens
TI:9606 None
 
DPH2_MOUSE
Ensembl»
4.6
Dph2 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (Diphthamide biosynthesis protein 2)
(Diphtheria toxin resistance protein 2) (MmDph2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase DPH2)		 Mus musculus
TI:10090 None
 
DPH2_RAT
RGD»
3.0
Dph2 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (Diphthamide biosynthesis protein 2)
(Diphtheria toxin resistance protein 2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2)		 Rattus norvegicus
TI:10116 None
 
DPH2_SCHPO
PomBase»
3.0
dph2 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (Diphthamide biosynthesis protein 2)
(Diphtheria toxin resistance protein 2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2)		 Schizosaccharomyces pombe
TI:4896 None
 
DPH2_YEAST
SGD»
4.5
DPH2 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (Diphthamide biosynthesis protein 2)
(Diphtheria toxin resistance protein 2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2)		 Saccharomyces cerevisiae
TI:4932 None
 
Q8RWW3_ARATH
TAIR»
3.7
MTG10.5 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (EC 2.5.1.108) (Diphthamide biosynthesis protein
1) (Diphtheria toxin resistance protein 1) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1)		 Arabidopsis thaliana
TI:3702 None
 
Q9M1A5_ARATH
TAIR»
1.3
T16L24.180 2-(3-amino-3-carboxypropyl)histidine synthase
subunit 2		 Arabidopsis thaliana
TI:3702 None
 
Q9VFE9_DROME
FlyBase»
2.1
Dph2 2-(3-amino-3-carboxypropyl)histidine synthase
subunit 2		 Drosophila melanogaster
TI:7227 None
 
Q9VTM2_DROME
FlyBase»
2.1
Dph1 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (EC 2.5.1.108) (Diphthamide biosynthesis protein
1) (Diphtheria toxin resistance protein 1) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1)		 Drosophila melanogaster
TI:7227 None