Collated Gene Ontology terms

Biological process: iron ion transmembrane transporter activity(2004, 2006, 2007, 2010, 2013, 2019, 2020, 2023, 2024, 2025) ferrous iron transmembrane transporter activity(2020, 2022, 2025) ATP:ADP antiporter activity(2025) ATP transmembrane transporter activity(2025) transferase activity(2025) tRNA binding(2025) tRNA (guanine(46)-N7)-methyltransferase activity(2025) nucleotide transmembrane transporter activity(2025) methyltransferase activity(2025) RNA binding(2025)

Molecular function: iron import into the mitochondrion2006, 2007, 2010, 2013, 2016, 2019, 2020, 2022, 2023, 2025 transmembrane transport2025 iron ion transport2025 monoatomic ion transport2025 positive regulation of hemoglobin biosynthetic process2021, 2025 iron ion transmembrane transport2025 mitochondrial ATP transmembrane transport2025 mitochondrial ADP transmembrane transport2025 multicellular organismal-level iron ion homeostasis2015, 2022 mRNA processing2025
cellular respiration2020 tRNA processing2025 tRNA modification2025 tRNA (guanine-N7)-methylation2025 spermatid differentiation2010 organic anion transport2025 methylation2025 intracellular iron ion homeostasis2022 erythrocyte maturation2006 erythrocyte development2015 embryonic hemopoiesis2012 cellular response to iron ion starvation2019

Cellular component: mitochondrial membrane2009, 2020, 2022, 2025 membrane2025 mitochondrial inner membrane2004, 2006, 2009, 2010, 2012, 2013, 2014, 2025 mitochondrion2002, 2006, 2007, 2009, 2013, 2014, 2018, 2019, 2020, 2021, 2022, 2024, 2025 kinetoplast2018, 2025 chloroplast2018 tRNA (m7G46) methyltransferase complex2025 plasma membrane2014 nucleus2025

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 15/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 2/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 39/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
MFRN1_MOUSE
Ensembl»
5.2
Slc25a37 Mitoferrin-1 (Mitochondrial iron transporter 1) (Mitochondrial solute
carrier protein) (Solute carrier family 25 member 37)		 Mus musculus
TI:10090 None
 
MFRN1_RAT
RGD»
3.5
Slc25a37 Mitoferrin-1 (Mitochondrial iron transporter 1)
(Solute carrier family 25 member 37)		 Rattus norvegicus
TI:10116 None
 
MFRN1_DANRE
ZFIN»
5.0
slc25a37 Mitoferrin-1 (Mitochondrial iron transporter 1) (Protein
frascati) (Solute carrier family 25 member 37)		 Danio rerio
TI:7955 None
 
MFRN1_HUMAN
Ensembl»
3.1
SLC25A37 Mitoferrin-1 (Mitochondrial iron transporter 1) (Mitochondrial solute
carrier protein) (Solute carrier family 25 member 37)		 Homo sapiens
TI:9606 None
 
MFRN_DROME
FlyBase»
4.2
mfrn Mitoferrin (dmfrn) Drosophila melanogaster
TI:7227 None
 
MRS4_YEAST
SGD»
3.4
MRS4 Mitochondrial RNA-splicing protein MRS4 Saccharomyces cerevisiae
TI:4932 None
 
O64731_ARATH
TAIR»
4.2
MIT1 Mitochondrial substrate carrier family
protein (Putative mitochondrial carrier protein)		 Arabidopsis thaliana
TI:3702 None
 
Q8L6Z2_ARATH
TAIR»
4.2
MIT2 At1g07030 (Mitochondrial carrier protein, putative)
(Mitochondrial substrate carrier family protein)		 Arabidopsis thaliana
TI:3702 None
 
F1NS09_CHICK
Ensembl»
1.0
SLC25A37 Mitoferrin-1 (Mitochondrial iron transporter 1)
(Solute carrier family 25 member 37)		 Gallus gallus
TI:9031 None
   
MFRN2_MOUSE
Ensembl»
1.8
Slc25a28 Mitoferrin-2 (Mitochondrial RNA-splicing protein 3/4 homolog) (MRS3/4) (Mitochondrial
iron transporter 2) (Solute carrier family 25 member 28)		 Mus musculus
TI:10090 None
 
MRS3_YEAST
SGD»
3.4
MRS3 Mitochondrial RNA-splicing protein MRS3 Saccharomyces cerevisiae
TI:4932 None
 
G3V865_RAT
RGD»
1.5
Slc25a28 Solute carrier family 25 member 28 Rattus norvegicus
TI:10116 None
   
MFRN2_HUMAN
Ensembl»
1.0
SLC25A28 Mitoferrin-2 (Mitochondrial RNA-splicing protein 3/4 homolog) (MRS3/4) (hMRS3/4) (Mitochondrial
iron transporter 2) (Solute carrier family 25 member 28)		 Homo sapiens
TI:9606 None
 
MFRN_DICDI
dictyBase»
2.0
mcfF Mitoferrin (Mitochondrial substrate
carrier family protein F)		 Dictyostelium discoideum
TI:44689 None
 
YETC_SCHPO
PomBase»
1.0
SPAC8C9.12c Uncharacterized mitochondrial carrier C8C9.12c Schizosaccharomyces pombe
TI:4896 None
 
F4HNW4_ARATH
TAIR»
1.0
At1g07025 Mitochondrial substrate carrier family protein Arabidopsis thaliana
TI:3702 None
 
MFRN2_DANRE
ZFIN»
1.0
slc25a28 Mitoferrin-2 (Mitochondrial iron transporter 2)
(Solute carrier family 25 member 28)		 Danio rerio
TI:7955 None
 
MFRN_CAEEL
WormBase»
1.0
mfn-1 Mitoferrin Caenorhabditis elegans
TI:6239 None
 
A0A8V0ZV06_CHICK
Ensembl»
0.0
SLC25A28 Solute carrier family 25 member 28 Gallus gallus
TI:9031 None
   
YAD8_SCHPO
PomBase»
1.0
SPAC4G8.08 Uncharacterized mitochondrial carrier C4G8.08 Schizosaccharomyces pombe
TI:4896 None
 
MCFE_DICDI
dictyBase»
0.0
mcfE Mitochondrial substrate carrier family protein E Dictyostelium discoideum
TI:44689 None
 
MCFU_DICDI
dictyBase»
0.0
mcfU Mitochondrial substrate carrier family protein U Dictyostelium discoideum
TI:44689 None