Collated Gene Ontology terms

Biological process: RNA binding(2007, 2014, 2017, 2025) translation initiation factor activity(2025) peptidase inhibitor activity(2025) nucleotide binding(2025) nucleic acid binding(2025) cysteine-type endopeptidase inhibitor activity(2025) alanine-tRNA ligase activity(2025) ATP binding(2025) ADP binding(2025)

Molecular function: mRNA splicing, via spliceosome2006, 2011, 2013, 2019, 2024, 2025 mRNA processing2025 RNA splicing2025 regulation of translation2025 ribosomal small subunit biogenesis2013, 2025 translational initiation2025 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2024, 2025 hyperosmotic response2013, 2025 hair follicle maturation2016 germ-line stem cell division2004, 2025
gastrulation2004, 2025 cell differentiation2004, 2025 translation2014 signal transduction2025 ribosome biogenesis2016 regulation of mRNA splicing, via spliceosome2007 regulation of cell cycle2007 post-transcriptional regulation of gene expression2016 mRNA cis splicing, via spliceosome2024 alanyl-tRNA aminoacylation2025

Cellular component: nucleolus2007, 2009, 2013, 2016, 2017, 2023, 2024, 2025 catalytic step 2 spliceosome2013, 2017, 2025 nucleus2004, 2013, 2017, 2018, 2019, 2025 nuclear speck2024, 2025 spliceosomal complex2006, 2007, 2025 U2-type precatalytic spliceosome2019, 2025 U2-type catalytic step 2 spliceosome2018, 2019, 2025 U2-type catalytic step 1 spliceosome2019, 2025 cytoplasm2025 post-spliceosomal complex2025
nucleoplasm2004, 2016, 2025 nuclear lumen2016, 2017, 2025 U2-type spliceosomal complex2013, 2025 germ cell nucleus2004, 2025 chromatin2004, 2025 Prp19 complex2024, 2025 FAL1-SGD1 complex2013, 2025 mitochondrion2018 cytosol2025

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 15/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 3/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 39/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
CWC22_HUMAN
Ensembl»
5.2
CWC22 Pre-mRNA-splicing factor CWC22
homolog (Nucampholin homolog) (fSAPb)		 Homo sapiens
TI:9606 None
 
CWC22_DROME
FlyBase»
1.5
ncm Pre-mRNA-splicing factor
CWC22 homolog (Nucampholin)		 Drosophila melanogaster
TI:7227 None
 
CWC22_MOUSE
Ensembl»
3.0
Cwc22 Pre-mRNA-splicing factor CWC22
homolog (Nucampholin homolog)		 Mus musculus
TI:10090 None
 
Q9SAG7_ARATH
TAIR»
1.0
At1g80930 At1g80930/F23A5_23 (F23A5.29 protein) (MIF4G domain-containing
protein / MA3 domain-containing protein)		 Arabidopsis thaliana
TI:3702 None
 
NOM1_HUMAN
Ensembl»
1.5
NOM1 Nucleolar MIF4G domain-containing
protein 1 (SGD1 homolog)		 Homo sapiens
TI:9606 None
 
Q67Z79_ARATH
TAIR»
1.0
MCM23.1 MIF4G domain-containing protein
/ MA3 domain-containing protein		 Arabidopsis thaliana
TI:3702 None
 
CWC22_CAEEL
WormBase»
3.9
let-858 Pre-mRNA-splicing factor CWC22 homolog
(Lethal protein 858) (Nucampholin)		 Caenorhabditis elegans
TI:6239 None
 
CWC22_SCHPO
PomBase»
1.8
cwf22 Pre-mRNA-splicing factor Cwf22 (Complexed
with cdc5 protein 22)		 Schizosaccharomyces pombe
TI:4896 None
 
CWC22_YEAST
SGD»
2.4
CWC22 Pre-mRNA-splicing factor CWC22 (Complexed
with CEF1 protein 22)		 Saccharomyces cerevisiae
TI:4932 None
 
NOM1_DROME
FlyBase»
1.0
CG9004 Nucleolar MIF4G domain-containing
protein 1 homolog		 Drosophila melanogaster
TI:7227 None
 
NOM1_MOUSE
Ensembl»
1.8
Nom1 Nucleolar MIF4G domain-containing
protein 1 (SGD1 homolog)		 Mus musculus
TI:10090 None
 
SGD1_YEAST
SGD»
3.4
SGD1 Suppressor of glycerol defect protein 1 Saccharomyces cerevisiae
TI:4932 None
 
CWC22_CHICK
TubercuList»
2.0
CWC22 Pre-mRNA-splicing factor CWC22
homolog (Nucampholin homolog)		 Gallus gallus
TI:9031 None
 
CWC22_DANRE
ZFIN»
2.0
cwc22 Pre-mRNA-splicing factor CWC22
homolog (Nucampholin homolog)		 Danio rerio
TI:7955 None
 
F4ICW3_ARATH
TAIR»
0.0
At1g52325 Initiation factor eIF-4 gamma, MA3 Arabidopsis thaliana
TI:3702 None
 
Q1LY17_DANRE
ZFIN»
1.8
nom1 Nucleolar MIF4G domain-containing
protein 1 (SGD1 homolog)		 Danio rerio
TI:7955 None
 
Q54PG9_DICDI
dictyBase»
1.0
DDB_G0284539 MI domain-containing protein Dictyostelium discoideum
TI:44689 None
 
Q55G70_DICDI
dictyBase»
1.5
DDB_G0267796 Initiation factor eIF-4
gamma middle domain-containing protein		 Dictyostelium discoideum
TI:44689 None
 
Q9U255_CAEEL
WormBase»
1.0
CELE_Y52B11A.10 Y52B11A.10 MI domain-containing protein Caenorhabditis elegans
TI:6239 None
 
SGD1_SCHPO
PomBase»
1.0
sgd1 Suppressor of glycerol defect protein 1 Schizosaccharomyces pombe
TI:4896 None
 
A0A8I6AUC8_RAT
RGD»
1.5
Nom1 Nucleolar MIF4G domain-containing
protein 1 (SGD1 homolog)		 Rattus norvegicus
TI:10116 None
   
A0A8I6GJW5_RAT
RGD»
2.0
Cwc22 Pre-mRNA-splicing factor CWC22
homolog (Nucampholin homolog)		 Rattus norvegicus
TI:10116 None
   
A0A8V1A366_CHICK
Ensembl»
1.0
NOM1 Nucleolar MIF4G domain-containing
protein 1 (SGD1 homolog)		 Gallus gallus
TI:9031 None
   
A0A8V1ACT5_CHICK
Ensembl»
1.0
CWC22 Pre-mRNA-splicing factor CWC22
homolog (Nucampholin homolog)		 Gallus gallus
TI:9031 None
   
A0ABK0LKE9_RAT
Ensembl»
0.0
LOC134479416 Pre-mRNA-splicing factor CWC22
homolog (Nucampholin homolog)		 Rattus norvegicus
TI:10116 None
   
A0ABK0LMI9_RAT
Ensembl»
0.0
Pre-mRNA-splicing factor CWC22
homolog (Nucampholin homolog)		 Rattus norvegicus
TI:10116 None
   
A2AK42_MOUSE
Ensembl»
2.0
Cwc22rt5 Pre-mRNA-splicing factor CWC22
homolog (Nucampholin homolog)		 Mus musculus
TI:10090 None
   
A2AK44_MOUSE
Ensembl»
2.0
Cwc22rt3 Pre-mRNA-splicing factor CWC22
homolog (Nucampholin homolog)		 Mus musculus
TI:10090 None