Collated Gene Ontology terms

Biological process: RNA binding(2007, 2014, 2017, 2023) translation initiation factor activity(2023) peptidase inhibitor activity(2023) nucleotide binding(2023) nucleic acid binding(2023) cysteine-type endopeptidase inhibitor activity(2023) alanine-tRNA ligase activity(2023) ATP binding(2023)

Molecular function: mRNA splicing, via spliceosome2006, 2011, 2017, 2019, 2023 regulation of translation2023 ribosomal small subunit biogenesis2010, 2017, 2023 mRNA processing2023 RNA splicing2023 hair follicle maturation2016, 2023 translational initiation2023 ribosome biogenesis2016, 2023 hyperosmotic response2007, 2023 germ-line stem cell division2004, 2022
gastrulation2004, 2022 cell differentiation2004, 2022 translation2014 ribosomal large subunit assembly2021 regulation of mRNA splicing, via spliceosome2007 regulation of cell cycle2007 post-transcriptional regulation of gene expression2016 maturation of SSU-rRNA2023 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2021 mRNA cis splicing, via spliceosome2005 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2021 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2021 alanyl-tRNA aminoacylation2023

Cellular component: catalytic step 2 spliceosome2011, 2013, 2017, 2023 nucleolus2007, 2009, 2016, 2017, 2023 nucleus2002, 2004, 2017, 2019, 2022, 2023 spliceosomal complex2006, 2007, 2023 nuclear speck2023 U2-type precatalytic spliceosome2019, 2023 U2-type catalytic step 2 spliceosome2018, 2019, 2023 U2-type catalytic step 1 spliceosome2019, 2023 cytosol2023 cytoplasm2023
membrane2023 U2-type spliceosomal complex2009, 2013, 2023 nucleoplasm2004, 2016, 2022 FAL1-SGD1 complex2012, 2015, 2023 small-subunit processome2023 nuclear lumen2016, 2017 germ cell nucleus2004, 2022 chromatin2004, 2022

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 16/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 2/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 37/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 0 2 4 6 8 10 Knownness

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
CWC22_MOUSE
Ensembl»
3.0
Cwc22 Pre-mRNA-splicing factor CWC22
homolog (Nucampholin homolog)		 Mus musculus
TI:10090 None
 
CWC22_HUMAN
Ensembl»
4.6
CWC22 Pre-mRNA-splicing factor CWC22
homolog (Nucampholin homolog) (fSAPb)		 Homo sapiens
TI:9606 None
 
A0A8I6GJW5_RAT
RGD»
2.0
Cwc22 CWC22 spliceosome associated protein homolog Rattus norvegicus
TI:10116 None
   
CWC22_CAEEL
WormBase»
3.9
let-858 Pre-mRNA-splicing factor CWC22 homolog
(Lethal protein 858) (Nucampholin)		 Caenorhabditis elegans
TI:6239 None
 
CWC22_CHICK
VEuPathDB»
2.0
CWC22 Pre-mRNA-splicing factor CWC22
homolog (Nucampholin homolog)		 Gallus gallus
TI:9031 None
 
CWC22_DANRE
ZFIN»
2.0
cwc22 Pre-mRNA-splicing factor CWC22
homolog (Nucampholin homolog)		 Danio rerio
TI:7955 None
 
A2AK42_MOUSE
Ensembl»
2.0
Cwc22rt5 Predicted gene 13691 (Predicted gene 13693) (Predicted gene 13694)
(Predicted gene 13696) (Predicted gene 13697) (Predicted gene 13698)		 Mus musculus
TI:10090 None
   
A2AK44_MOUSE
Ensembl»
2.0
Cwc22rt3 Predicted gene 13695 Mus musculus
TI:10090 None
   
SGD1_YEAST
SGD»
3.2
SGD1 Suppressor of glycerol defect protein 1 Saccharomyces cerevisiae
TI:4932 None
 
CWC22_SCHPO
PomBase»
1.5
cwf22 Pre-mRNA-splicing factor cwf22 (Complexed
with cdc5 protein 22)		 Schizosaccharomyces pombe
TI:4896 None
 
CWC22_YEAST
SGD»
1.8
CWC22 Pre-mRNA-splicing factor CWC22 (Complexed
with CEF1 protein 22)		 Saccharomyces cerevisiae
TI:4932 None
 
CWC22_DROME
FlyBase»
1.5
ncm Pre-mRNA-splicing factor
CWC22 homolog (Nucampholin)		 Drosophila melanogaster
TI:7227 None
 
NOM1_HUMAN
Ensembl»
1.5
NOM1 Nucleolar MIF4G domain-containing
protein 1 (SGD1 homolog)		 Homo sapiens
TI:9606 None
 
NOM1_MOUSE
Ensembl»
1.8
Nom1 Nucleolar MIF4G domain-containing
protein 1 (SGD1 homolog)		 Mus musculus
TI:10090 None
 
Q55G70_DICDI
dictyBase»
1.5
DDB_G0267796 Initiation factor eIF-4
gamma middle domain-containing protein		 Dictyostelium discoideum
TI:44689 None
 
SGD1_SCHPO
PomBase»
1.5
sgd1 Suppressor of glycerol defect protein 1 Schizosaccharomyces pombe
TI:4896 None
 
NOM1_DROME
FlyBase»
1.0
CG9004 Nucleolar MIF4G domain-containing
protein 1 homolog		 Drosophila melanogaster
TI:7227 None
 
A0A8I6AUC8_RAT
RGD»
0.5
Nom1 Nucleolar protein with MIF4G domain 1 Rattus norvegicus
TI:10116 None
   
Q1LY17_DANRE
ZFIN»
1.8
si:ch211-266o5.1 Nucleolar MIF4G domain-containing protein 1 isoform
1 (Nucleolar protein with MIF4G domain 1)		 Danio rerio
TI:7955 None
 
Q54PG9_DICDI
dictyBase»
1.0
DDB_G0284539 MI domain-containing protein Dictyostelium discoideum
TI:44689 None
 
Q9U255_CAEEL
WormBase»
1.0
CELE_Y52B11A.10 Y52B11A.10 MI domain-containing protein Caenorhabditis elegans
TI:6239 None
 
F4ICW3_ARATH
TAIR»
0.0
At1g52325 Initiation factor eIF-4 gamma, MA3 Arabidopsis thaliana
TI:3702 None
 
Q67Z79_ARATH
TAIR»
0.0
MCM23.1 MIF4G domain-containing protein / MA3
domain-containing protein (Uncharacterized protein At5g17930)		 Arabidopsis thaliana
TI:3702 None
 
Q9SAG7_ARATH
TAIR»
0.0
At1g80930 At1g80930/F23A5_23 (F23A5.29 protein) (MIF4G domain-containing
protein / MA3 domain-containing protein)		 Arabidopsis thaliana
TI:3702 None
 
A0A8V1A366_CHICK
Ensembl»
0.0
NOM1 Nucleolar protein with MIF4G domain 1 Gallus gallus
TI:9031 None
   
A0A8V1ACT5_CHICK
Ensembl»
0.0
CWC22 CWC22 spliceosome associated protein homolog Gallus gallus
TI:9031 None