Collated Gene Ontology terms

Biological process: pyruvate dehydrogenase (acetyl-transferring) activity(2003, 2004, 2007, 2010, 2012, 2013, 2022, 2024, 2025) oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(2009, 2025) oxidoreductase activity(2025) metal ion binding(2025) pyruvate synthase activity(2025) magnesium ion binding(2025) DNA binding(2025) 2-oxoglutarate synthase activity(2025) 2-oxobutyrate synthase activity(2025) zinc ion binding(2021)
diacetyl reductase ((R)-acetoin forming) (NAD+) activity2025 cobalt ion binding2021

Molecular function: pyruvate decarboxylation to acetyl-CoA2004, 2007, 2012, 2013, 2019, 2025 glucose metabolic process2025 tricarboxylic acid cycle2025 pseudohyphal growth2014, 2025 response to hormone2025 regulation of DNA-templated transcription2025 branched-chain amino acid catabolic process2025 response to cadmium ion2010 pyruvate catabolic process2010 fatty acid biosynthetic process2009
carbon utilization2010 acetoin catabolic process2025

Cellular component: pyruvate dehydrogenase complex2004, 2007, 2010, 2012, 2013, 2019, 2024, 2025 mitochondrion2003, 2009, 2012, 2014, 2016, 2018, 2019, 2021, 2024, 2025 mitochondrial matrix2015, 2016, 2025 protein-containing complex2022, 2025 nucleus2014, 2019, 2025 mitochondrial nucleoid2013, 2025 chloroplast2018, 2021, 2025 cytosol2011, 2019 nucleolus2025 cytoplasm2016, 2017
plastid2019 phagocytic vesicle2006 myelin sheath2014 chloroplast stroma2021 chloroplast envelope2021 apicoplast2009

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 15/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 2/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 39/39 
Archea: 1/8 
Bacteria: 15/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
A0ABK0LJR0_RAT
Ensembl»
0.0
Pyruvate dehydrogenase E1 component
subunit alpha (EC 1.2.4.1)		 Rattus norvegicus
TI:10116 None
   
E7F9W7_DANRE
ZFIN»
1.0
pdha1b Pyruvate dehydrogenase E1 component
subunit alpha (EC 1.2.4.1)		 Danio rerio
TI:7955 None
 
ODPA1_ARATH
TAIR»
1.8
E1 ALPHA Pyruvate dehydrogenase E1 component subunit
alpha-1, mitochondrial (PDHE1-A) (EC 1.2.4.1)		 Arabidopsis thaliana
TI:3702 None
 
ODPA2_ARATH
TAIR»
2.0
IAR4 Pyruvate dehydrogenase E1 component subunit alpha-2,
mitochondrial (PDHE1-A) (EC 1.2.4.1) (Protein IAA-CONJUGATE-RESISTANT 4)		 Arabidopsis thaliana
TI:3702 None
 
ODPA3_ARATH
TAIR»
1.0
PDH-E1 ALPHA Pyruvate dehydrogenase E1 component
subunit alpha-3, chloroplastic (EC 1.2.4.1)		 Arabidopsis thaliana
TI:3702 None
 
ODPAT_HUMAN
Ensembl»
4.5
PDHA2 Pyruvate dehydrogenase E1 component subunit alpha, testis-specific
form, mitochondrial (EC 1.2.4.1) (PDHE1-A type II)		 Homo sapiens
TI:9606 None
 
ODPAT_MOUSE
Ensembl»
3.0
Pdha2 Pyruvate dehydrogenase E1 component subunit alpha, testis-specific
form, mitochondrial (EC 1.2.4.1) (PDHE1-A type II)		 Mus musculus
TI:10090 None
 
ODPAT_RAT
RGD»
3.6
Pdha2 Pyruvate dehydrogenase E1 component subunit alpha, testis-specific
form, mitochondrial (EC 1.2.4.1) (PDHE1-A type II)		 Rattus norvegicus
TI:10116 None
 
ODPA_CAEEL
WormBase»
1.0
pdha-1 Probable pyruvate dehydrogenase E1 component
subunit alpha, mitochondrial (PDHE1-A) (EC 1.2.4.1)		 Caenorhabditis elegans
TI:6239 None
 
ODPA_DICDI
dictyBase»
2.0
pdhA Pyruvate dehydrogenase E1 component subunit
alpha, mitochondrial (PDHE1-A) (EC 1.2.4.1)		 Dictyostelium discoideum
TI:44689 None
 
ODPA_HUMAN
Ensembl»
2.1
PDHA1 Pyruvate dehydrogenase E1 component subunit alpha, somatic
form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)		 Homo sapiens
TI:9606 None
 
ODPA_MOUSE
Ensembl»
4.1
Pdha1 Pyruvate dehydrogenase E1 component subunit alpha, somatic
form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)		 Mus musculus
TI:10090 None
 
ODPA_RAT
RGD»
4.1
Pdha1 Pyruvate dehydrogenase E1 component subunit alpha, somatic
form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)		 Rattus norvegicus
TI:10116 None
 
ODPA_SCHPO
PomBase»
1.0
pda1 Pyruvate dehydrogenase E1 component subunit
alpha, mitochondrial (PDHE1-A) (EC 1.2.4.1)		 Schizosaccharomyces pombe
TI:4896 None
 
ODPA_YEAST
SGD»
4.0
PDA1 Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial (EC
1.2.4.1) (Pyruvate dehydrogenase complex component E1 alpha) (PDHE1-A)		 Saccharomyces cerevisiae
TI:4932 None
 
Q5F426_CHICK
Ensembl»
0.0
PDHA2 Pyruvate dehydrogenase E1 component
subunit alpha (EC 1.2.4.1)		 Gallus gallus
TI:9031 None
 
Q7KVX1_DROME
FlyBase»
2.0
Pdha1 Pyruvate dehydrogenase E1 component
subunit alpha (EC 1.2.4.1)		 Drosophila melanogaster
TI:7227 None
 
Q9W4H4_DROME
FlyBase»
1.0
Pdha2 Pyruvate dehydrogenase E1 component
subunit alpha (EC 1.2.4.1)		 Drosophila melanogaster
TI:7227 None