Collated Gene Ontology terms

Biological process: protein-folding chaperone binding(2005, 2013, 2017, 2021, 2025) nucleotide binding(2025) ATP binding(2025) ABC-type protein transporter activity(2003, 2025) protein-macromolecule adaptor activity(2013, 2025) protein-transporting ATPase activity(2004, 2007) protein serine/threonine kinase activity(2025) protein kinase activity(2025) enzyme binding(2025) DNA binding(2025)
ATP-dependent DNA damage sensor activity2025 ATP hydrolysis activity2023

Molecular function: protein import into mitochondrial matrix2004, 2016, 2017, 2021, 2025 protein transport2025 protein targeting to mitochondrion2003, 2004, 2007, 2025 establishment of protein localization2025 intracellular protein transport2005, 2024, 2025 signal transduction2025 response to 3,3',5-triiodo-L-thyronine2017 protein transmembrane transport2025 cellular response to hypoxia2011 cardiac muscle cell differentiation2017
DNA repair2025

Cellular component: mitochondrial inner membrane2005, 2007, 2011, 2014, 2019, 2024, 2025 TIM23 mitochondrial import inner membrane translocase complex2003, 2016, 2023, 2025 mitochondrion2007, 2009, 2018, 2021, 2024, 2025 mitochondrial matrix2011, 2025 PAM complex, Tim23 associated import motor2004, 2013, 2021, 2025 extrinsic component of mitochondrial inner membrane2016, 2025 plasma membrane2014 nucleus2025 membrane2025 fibrillar center2025
cytoplasm2025

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 15/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 1/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 39/39 
Archea: 0/8 
Bacteria: 1/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
TIM44_MOUSE
Ensembl»
2.5
Timm44 Mitochondrial import inner
membrane translocase subunit TIM44		 Mus musculus
TI:10090 None
 
TIM44_RAT
RGD»
4.2
Timm44 Mitochondrial import inner
membrane translocase subunit TIM44		 Rattus norvegicus
TI:10116 None
 
TIM44_YEAST
SGD»
4.8
TIM44 Mitochondrial import inner membrane translocase subunit TIM44 (Inner membrane import site protein
45) (ISP45) (Membrane import machinery protein MIM44) (Mitochondrial protein import protein 1)		 Saccharomyces cerevisiae
TI:4932 None
 
TIM44_HUMAN
Ensembl»
2.5
TIMM44 Mitochondrial import inner
membrane translocase subunit TIM44		 Homo sapiens
TI:9606 None
 
Q5A7M2_CANAL
CGD»
0.0
TIM44 Mitochondrial import inner
membrane translocase subunit TIM44		 Candida albicans
TI:5476 None
 
Q9VDZ7_DROME
FlyBase»
2.8
CG117799 Mitochondrial import inner
membrane translocase subunit TIM44		 Drosophila melanogaster
TI:7227 None
 
A0A6I8PBJ5_ORNAN
Ensembl»
0.0
TIMM44 Mitochondrial import inner
membrane translocase subunit TIM44		 Ornithorhynchus anatinus
TI:9258 None
   
A0A8I3SBU7_CANLF
Ensembl»
0.0
TIMM44 Mitochondrial import inner
membrane translocase subunit TIM44		 Canis lupus
TI:9612 None
   
B6JZN5_SCHJY
TubercuList»
0.0
tim44 Mitochondrial import inner
membrane translocase subunit TIM44		 Schizosaccharomyces japonicus
TI:4897 None
 
E1B844_BOVIN
Ensembl»
0.0
TIMM44 Mitochondrial import inner
membrane translocase subunit TIM44		 Bos taurus
TI:9913 None
   
F7ASY3_MONDO
Ensembl»
0.0
TIMM44 Mitochondrial import inner
membrane translocase subunit TIM44		 Monodelphis domestica
TI:13616 None
   
F7HS29_MACMU
Ensembl»
0.0
TIMM44 Mitochondrial import inner
membrane translocase subunit TIM44		 Macaca mulatta
TI:9544 None
   
G3QR78_GORGO
Ensembl»
0.0
TIMM44 Mitochondrial import inner
membrane translocase subunit TIM44		 Gorilla gorilla
TI:9593 None
 
H2QF76_PANTR
Ensembl»
0.0
TIMM44 Mitochondrial import inner
membrane translocase subunit TIM44		 Pan troglodytes
TI:9598 None
 
Q5KEX5_CRYD1
TubercuList»
0.0
CNF03880 Mitochondrial import inner
membrane translocase subunit TIM44		 Cryptococcus deneoformans
TI:40410 None
 
Q6C8B1_YARLI
TubercuList»
0.0
YALI0_D21142g Mitochondrial import inner
membrane translocase subunit TIM44		 Yarrowia lipolytica
TI:4952 None
 
Q75AP0_EREGS
euHCVdb»
0.0
AGOS_ADL118C Mitochondrial import inner
membrane translocase subunit TIM44		 Eremothecium gossypii
TI:33169 None
 
TI442_ARATH
TAIR»
2.8
TIM44-2 Mitochondrial import inner
membrane translocase subunit TIM44-2		 Arabidopsis thaliana
TI:3702 None
 
TIM44_SCHPO
PomBase»
3.0
tim44 Mitochondrial import inner
membrane translocase subunit tim44		 Schizosaccharomyces pombe
TI:4896 None
 
TI441_ARATH
TAIR»
2.8
TIM44-1 Mitochondrial import inner
membrane translocase subunit TIM44-1		 Arabidopsis thaliana
TI:3702 None
 
A0A3B3I800_ORYLA
Ensembl»
0.0
timm44 Mitochondrial import inner
membrane translocase subunit TIM44		 Oryzias latipes
TI:8090 None
   
A0A480JTC0_PIG
Ensembl»
0.0
TIMM44 Mitochondrial import inner
membrane translocase subunit TIM44		 Sus scrofa
TI:9823 None
 
A0A7M7N9W0_STRPU
EnsemblMetazoa»
0.0
Mitochondrial import inner
membrane translocase subunit TIM44		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A8J0SE15_XENTR
Xenbase»
0.0
timm44 Mitochondrial import inner
membrane translocase subunit TIM44		 Xenopus tropicalis
TI:8364 None
   
A0A8J0TRA3_XENLA
Xenbase»
0.0
timm44.S Mitochondrial import inner
membrane translocase subunit TIM44		 Xenopus laevis
TI:8355 None
   
B7QIK5_IXOSC
EnsemblMetazoa»
0.0
8041787 Mitochondrial import inner
membrane translocase subunit TIM44		 Ixodes scapularis
TI:6945 None
 
D1ZZZ0_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_08130 Mitochondrial import inner
membrane translocase subunit TIM44		 Tribolium castaneum
TI:7070 None
 
E9GRP7_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_305300 Mitochondrial import inner
membrane translocase subunit TIM44		 Daphnia pulex
TI:6669 None
 
F1NU71_CHICK
Ensembl»
0.0
TIMM44 Mitochondrial import inner
membrane translocase subunit TIM44		 Gallus gallus
TI:9031 None
   
F6S578_CIOIN
Ensembl»
0.0
LOC100186487 Mitochondrial import inner
membrane translocase subunit TIM44		 Ciona intestinalis
TI:7719 None
 
H2MFT8_ORYLA
Ensembl»
0.0
TIMM44 Mitochondrial import inner
membrane translocase subunit TIM44		 Oryzias latipes
TI:8090 None
   
Q5BLH8_DANRE
ZFIN»
1.0
timm44 Mitochondrial import inner
membrane translocase subunit TIM44		 Danio rerio
TI:7955 None
 
Q7Q8M7_ANOGA
EnsemblMetazoa»
0.0
1275400 Mitochondrial import inner
membrane translocase subunit TIM44		 Anopheles gambiae
TI:7165 None
 
Q7QF41_ANOGA
EnsemblMetazoa»
0.0
1271968 Mitochondrial import inner
membrane translocase subunit TIM44		 Anopheles gambiae
TI:7165 None
 
T1FYI2_HELRO
EnsemblMetazoa»
0.0
20213880 Mitochondrial import inner
membrane translocase subunit TIM44		 Helobdella robusta
TI:6412 None
 
W5MAA0_LEPOC
Ensembl»
0.0
Mitochondrial import inner
membrane translocase subunit TIM44		 Lepisosteus oculatus
TI:7918 None
 
A0A1U8LHG8_GOSHI
euHCVdb»
0.0
LOC107927508 Mitochondrial import inner
membrane translocase subunit TIM44-2		 Gossypium hirsutum
TI:3635 None
   
A0A1U8MPV5_GOSHI
euHCVdb»
0.0
LOC107939963 Mitochondrial import inner
membrane translocase subunit TIM44-2		 Gossypium hirsutum
TI:3635 None
   
A0A9R0HSW8_SPIOL
euHCVdb»
0.0
LOC110776163 Mitochondrial import inner membrane
translocase subunit TIM44-2 isoform X1		 Spinacia oleracea
TI:3562 None
   
A0A9R0ILD2_SPIOL
euHCVdb»
0.0
LOC110791020 Mitochondrial import inner membrane
translocase subunit TIM44-2-like isoform X1		 Spinacia oleracea
TI:3562 None
   
A7EMD9_SCLS1
TubercuList»
0.0
SS1G_06487 Mitochondrial import inner
membrane translocase subunit TIM44		 Sclerotinia sclerotiorum
TI:5180 None
 
H3GKR7_PHYRM
EnsemblProtists»
0.0
RecA family profile 1 domain-containing protein Phytophthora ramorum
TI:164328 None
 
A0A2A6CCQ9_PRIPA
EnsemblMetazoa»
0.0
WBGene00278345 Tin-44 Pristionchus pacificus
TI:54126 None
   
Q8IIA9_PLAF7
TubercuList»
0.0
PF3D7_1125400 Mitochondrial import inner membrane
translocase subunit TIM44, putative		 Plasmodium falciparum
TI:5833 None
 
A0A061DP09_THECC
euHCVdb»
0.0
TCM_004034 Translocase inner membrane
subunit 44-2 isoform 1		 Theobroma cacao
TI:3641 None
 
A0A067F2Y4_CITSI
euHCVdb»
0.0
CISIN_1g011958mg Tim44-like domain-containing protein Citrus sinensis
TI:2711 None
 
A0A0K9PJ99_ZOSMR
euHCVdb»
0.0
ZOSMA_221G00240 Putative Mitochondrial import inner
membrane translocase subunit tim44,putative		 Zostera marina
TI:29655 None
 
A0A1U8AAP9_NELNU
euHCVdb»
0.0
LOC104600873 Mitochondrial import inner
membrane translocase subunit TIM44-2		 Nelumbo nucifera
TI:4432 None
   
A0A2C9UNK5_MANES
euHCVdb»
0.0
MANES_13G034400v8 Tim44-like domain-containing protein Manihot esculenta
TI:3983 None
 
A0A2C9UUD1_MANES
euHCVdb»
0.0
MANES_12G032400v8 Tim44-like domain-containing protein Manihot esculenta
TI:3983 None
 
A0A2I4H8R1_JUGRE
euHCVdb»
0.0
LOC109014499 Mitochondrial import inner
membrane translocase subunit TIM44-2-like		 Juglans regia
TI:51240 None
   
A0A2K1KP65_PHYPA
EnsemblPlants»
0.0
LOC112280771 Tim44-like domain-containing protein Physcomitrium patens
TI:3218 None
 
A0A2X0S2S5_WHEAT
EnsemblPlants»
0.0
LOC123052017 Tim44-like domain-containing protein Triticum aestivum
TI:4565 None
   
A0A3B6ATL3_WHEAT
EnsemblPlants»
0.0
LOC123187884 Tim44-like domain-containing protein Triticum aestivum
TI:4565 None
   
A0A3B6C283_WHEAT
EnsemblPlants»
0.0
LOC123044140 Tim44-like domain-containing protein Triticum aestivum
TI:4565 None
   
A0A3Q7EMK5_SOLLC
EnsemblPlants»
0.0
LOC101251332 Tim44-like domain-containing protein Solanum lycopersicum
TI:4081 None
   
A0A804K444_MUSAM
EnsemblPlants»
0.0
GSMUA_341500.1 (wild Malaysian banana) hypothetical protein Musa acuminata
TI:4641 None
 
A0A9J7HXD2_BRAFL
euHCVdb»
0.0
LOC118408886 Mitochondrial import inner
membrane translocase subunit TIM44-like		 Branchiostoma floridae
TI:7739 None
   
A0A9L0RWT6_HORSE
Ensembl»
0.0
TIMM44 Translocase of inner mitochondrial membrane 44 Equus caballus
TI:9796 None
   
A8XG07_CAEBR
WormBase»
0.0
tin-44 Mitochondrial import inner
membrane translocase subunit TIM44		 Caenorhabditis briggsae
TI:6238 None
 
B3RSD1_TRIAD
CTD»
0.0
TRIADDRAFT_54556 Mitochondrial import inner
membrane translocase subunit TIM44		 Trichoplax adhaerens
TI:10228 None
 
B4FDK0_MAIZE
EnsemblPlants»
0.0
LOC100193036 Mitochondrial import inner
membrane translocase subunit TIM44-2		 Zea mays
TI:4577 None
 
B9GS13_POPTR
euHCVdb»
0.0
POPTR_002G038300 Tim44-like domain-containing protein Populus trichocarpa
TI:3694 None
 
B9SF39_RICCO
euHCVdb»
0.0
RCOM_1213600 Mitochondrial import inner membrane
translocase subunit tim44, putative		 Ricinus communis
TI:3988 None
 
C5X6E8_SORBI
euHCVdb»
0.0
SORBI_3002G428100 Tim44-like domain-containing protein Sorghum bicolor
TI:4558 None
 
C8VSF8_EMENI
TubercuList»
0.0
ANIA_01281 Mitochondrial import inner
membrane translocase subunit TIM44		 Emericella nidulans
TI:162425 None
 
D7U300_VITVI
euHCVdb»
0.0
VIT_07s0005g03380 Tim44-like domain-containing protein Vitis vinifera
TI:29760 None
 
F2D9Y1_HORVV
EnsemblPlants»
0.0
LOC123425224 Predicted protein Hordeum vulgare
TI:4513 None
 
G7IM56_MEDTR
EnsemblPlants»
0.0
11412031 Import inner membrane translocase subunit
TIM44-2 (Putative NTF2-like domain-containing protein)		 Medicago truncatula
TI:3880 None
 
I1GS43_BRADI
EnsemblPlants»
0.0
LOC100837656 Tim44-like domain-containing protein Brachypodium distachyon
TI:15368 None
 
I1JVJ8_SOYBN
EnsemblPlants»
0.0
LOC100784560 Tim44-like domain-containing protein Glycine max
TI:3847 None
 
K4A9D9_SETIT
EnsemblPlants»
0.0
LOC101756060 Tim44-like domain-containing protein Setaria italica
TI:4555 None
 
M5VM00_PRUPE
euHCVdb»
0.0
PRUPE_8G223600 Tim44-like domain-containing protein Prunus persica
TI:3760 None
 
Q1K930_NEUCR
TubercuList»
0.0
tim44 Mitochondrial import inner
membrane translocase subunit TIM44		 Neurospora crassa
TI:5141 None
 
Q4WTB9_ASPFU
TubercuList»
0.0
AFUA_1G09840 Mitochondrial import inner
membrane translocase subunit TIM44		 Aspergillus fumigatus
TI:746128 None
 
Q69V11_ORYSJ
euHCVdb»
0.0
Os07g0409700 Os07g0409700 protein (cDNA clone:J013040N20, full insert
sequence) (cDNA clone:J023006L22, full insert sequence)		 Oryza sativa
TI:4530 None
 
TIM44_CAEEL
WormBase»
1.0
tin-44 Probable mitochondrial import inner
membrane translocase subunit tin-44		 Caenorhabditis elegans
TI:6239 None
 
A0A1S4B373_TOBAC
euHCVdb»
0.0
LOC107804069 Mitochondrial import inner
membrane translocase subunit TIM44-2-like		 Nicotiana tabacum
TI:4097 None
   
A0A1S4DBS0_TOBAC
euHCVdb»
0.0
LOC107828135 Mitochondrial import inner membrane
translocase subunit TIM44-2 isoform X2		 Nicotiana tabacum
TI:4097 None
   
M1C1V7_SOLTU
EnsemblPlants»
0.0
Mitochondrial import inner
membrane translocase subunit tim44		 Solanum tuberosum
TI:4113 None
   
A0A022RKG5_ERYGU
euHCVdb»
0.0
MIMGU_mgv1a005111mg Tim44-like domain-containing protein Erythranthe guttata
TI:4155 None
 
A0A022RQE2_ERYGU
neXtProt»
0.0
MIMGU_mgv1a005119mg Tim44-like domain-containing protein Erythranthe guttata
TI:4155 None
 
A0A072UXK5_MEDTR
EnsemblPlants»
0.0
25492859 Import inner membrane translocase subunit TIM44-2
(Putative RGS domain, NTF2-like domain-containing protein)		 Medicago truncatula
TI:3880 None
 
A0A078H516_BRANA
euHCVdb»
0.0
BnaA07g00370D (rape) hypothetical
protein (BnaA07g00370D protein)		 Brassica napus
TI:3708 None
 
A0A078HMM2_BRANA
neXtProt»
0.0
BnaA09g10320D (rape) hypothetical
protein (BnaA09g10320D protein)		 Brassica napus
TI:3708 None
 
A0A1Y1HK16_KLENI
neXtProt»
0.0
KFL_000200580 TIM44 mitochondrial import
inner membrane translocon protein		 Klebsormidium nitens
TI:105231 None
 
A0A251RYK2_HELAN
neXtProt»
0.0
ATTIM44-2 Putative translocase inner membrane subunit 44-2
(Tim44-like domain, NTF2-like domain superfamily protein)		 Helianthus annuus
TI:4232 None
 
A0A2G2YZ31_CAPAN
euHCVdb»
0.0
T459_22297 Mitochondrial import inner
membrane translocase subunit TIM44-2		 Capsicum annuum
TI:4072 None
 
A0A2K2AKR2_POPTR
neXtProt»
0.0
POPTR_005G224500 Tim44-like domain-containing protein Populus trichocarpa
TI:3694 None
 
A0A2K3CTI6_CHLRE
euHCVdb»
0.0
CHLRE_16g660800v5 Tim44-like domain-containing protein Chlamydomonas reinhardtii
TI:3055 None
 
A0A2R6WNX2_MARPO
neXtProt»
0.0
MARPO_0070s0010 Tim44-like domain-containing protein Marchantia polymorpha
TI:3197 None
 
A0A7U2FBN2_PHANO
TubercuList»
0.0
JI435_069140 Mitochondrial import inner
membrane translocase subunit TIM44		 Phaeosphaeria nodorum
TI:13684 None
 
A0A9R1X3U7_LACSA
euHCVdb»
0.0
LSAT_V11C700372260 Tim44-like domain-containing protein Lactuca sativa
TI:4236 None
 
A0ABI8AM27_FELCA
Ensembl»
0.0
TIMM44 Mitochondrial import inner
membrane translocase subunit TIM44		 Felis catus
TI:9685 None
   
A0C1I5_PARTE
neXtProt»
0.0
GSPATT00034128001 Tim44-like domain-containing protein Paramecium tetraurelia
TI:5888 None
 
A0CBB5_PARTE
euHCVdb»
0.0
GSPATT00036865001 Tim44-like domain-containing protein Paramecium tetraurelia
TI:5888 None
 
A2F7V1_TRIV3
TubercuList»
0.0
TVAG_008790 Tim44-like domain-containing protein Trichomonas vaginalis
TI:5722 None
 
A9S8R1_PHYPA
EnsemblPlants»
0.0
LOC112289178 Tim44-like domain-containing protein Physcomitrium patens
TI:3218 None
 
A9V3Z3_MONBE
neXtProt»
0.0
MONBRDRAFT_37779 Tim44-like domain-containing protein Monosiga brevicollis
TI:81824 None
 
D8R0Z0_SELML
euHCVdb»
0.0
SELMODRAFT_83588 Tim44-like domain-containing protein Selaginella moellendorffii
TI:88036 None
 
D8S158_SELML
euHCVdb»
0.0
SELMODRAFT_176052 Tim44-like domain-containing protein Selaginella moellendorffii
TI:88036 None
 
E3KHB2_PUCGT
TubercuList»
0.0
PGTG_09400 Tim44-like domain-containing protein Puccinia graminis
TI:5297 None
 
F4P7Z6_BATDJ
euHCVdb»
0.0
BATDEDRAFT_90410 Tim44-like domain-containing protein Batrachochytrium dendrobatidis
TI:109871 None
 
G7JJL0_MEDTR
EnsemblPlants»
0.0
MTR_4g029490 Import inner membrane
translocase subunit TIM44-2		 Medicago truncatula
TI:3880 None
 
M4F5X2_BRACM
EnsemblPlants»
0.0
Tim44-like domain-containing protein Brassica campestris
TI:3711 None
   
M4F6G4_BRACM
EnsemblPlants»
0.0
Tim44-like domain-containing protein Brassica campestris
TI:3711 None
   
U5DEB7_AMBTC
euHCVdb»
0.0
AMTR_s00067p00028100 Tim44-like domain-containing protein Amborella trichopoda
TI:13333 None
 
A0A251TK99_HELAN
neXtProt»
0.0
HannXRQ_Chr10g0294161 HanXRQr2_Chr10g0431831 Uncharacterized protein Helianthus annuus
TI:4232 None
 
A0A0A0KPP0_CUCSA
neXtProt»
0.0
Csa_5G576800 Tim44-like domain-containing protein Cucumis sativus
TI:3659 None
 
A0A2K2DSR0_BRADI
EnsemblPlants»
0.0
BRADI_1g60993v3 Tim44-like domain-containing protein Brachypodium distachyon
TI:15368 None
 
A7SUW6_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g41423 Tim44-like domain-containing protein Nematostella vectensis
TI:45351 None
 
B8BZ52_THAPS
euHCVdb»
0.0
THAPSDRAFT_262136 Tim44-like protein Thalassiosira pseudonana
TI:35128 None
 
K7LB35_SOYBN
EnsemblPlants»
0.0
GLYMA_09G002800 Tim44-like domain-containing protein Glycine max
TI:3847 None
 
Q89WN6_BRADU
EnsemblBacteria»
0.0
blr0642 Blr0642 protein Bradyrhizobium diazoefficiens
TI:1355477 None
 
A0A0A0KRQ0_CUCSA
euHCVdb»
0.0
Csa_5G576810 Uncharacterized protein Cucumis sativus
TI:3659 None 		 
 
A0A2G2YDX5_CAPAN
euHCVdb»
0.0
T459_27386 Uncharacterized protein Capsicum annuum
TI:4072 None