Collated Gene Ontology terms

Biological process: DNA binding(2019, 2025)

Molecular function: regulation of DNA stability2019, 2025 cellular response to hydroxyurea2019, 2025 DNA replication termination2025 replication fork processing2024 replication fork arrest2024 mRNA splicing, via spliceosome2024 mRNA processing2025 head development2020 embryonic body morphogenesis2018 alternative mRNA splicing, via spliceosome2015
RNA splicing2025

Cellular component: nucleus2009, 2016, 2025 replication fork2018, 2019, 2024, 2025 nucleoplasm2016, 2017, 2024, 2025 nucleolus2016, 2017, 2024, 2025 chromosome2025 spliceosomal complex2024

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 4/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 13/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 3/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 39/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
U5D8W5_AMBTC
neXtProt»
0.0
AMTR_s00065p00181400 Ubiquitin-like domain-containing protein Amborella trichopoda
TI:13333 None
 
H9GMW6_ANOCA
Ensembl»
0.0
RTF2 Replication termination factor 2 (Replication
termination factor 2 domain-containing protein 1)		 Anolis carolinensis
TI:28377 None
   
A0A1S4H377_ANOGA
EnsemblMetazoa»
0.0
Replication termination factor 2 (Replication
termination factor 2 domain-containing protein 1)		 Anopheles gambiae
TI:7165 None
 
Q7PCR9_ANOGA
EnsemblMetazoa»
0.0
AgaP_AGAP010176 AgaP_AGAP012690 Replication termination factor 2 (Replication
termination factor 2 domain-containing protein 1)		 Anopheles gambiae
TI:7165 None
 
Q6NQ98_ARATH
TAIR»
0.8
RTF2 At5g58020 (RTF2 RING-finger protein) Arabidopsis thaliana
TI:3702 None
 
Q4WG81_ASPFU
TubercuList»
0.0
AFUA_7G04100 Replication termination factor 2 Aspergillus fumigatus
TI:746128 None
 
F4PDB2_BATDJ
euHCVdb»
0.0
BATDEDRAFT_28211 Uncharacterized protein Batrachochytrium dendrobatidis
TI:109871 None
 
F1MNT2_BOVIN
Ensembl»
0.0
RTF2 Replication termination factor 2 (Replication
termination factor 2 domain-containing protein 1)		 Bos taurus
TI:9913 None
   
RTF2_BOVIN
CTD»
0.0
RTF2 Replication termination factor 2 (RTF2) (Replication
termination factor 2 domain-containing protein 1)		 Bos taurus
TI:9913 None
 
I1H0C7_BRADI
EnsemblPlants»
0.0
LOC100827559 Uncharacterized protein Brachypodium distachyon
TI:15368 None
 
A0A9J7L086_BRAFL
euHCVdb»
0.0
LOC118413956 Replication termination factor 2 (Replication
termination factor 2 domain-containing protein 1)		 Branchiostoma floridae
TI:7739 None
   
A0A078H5J2_BRANA
neXtProt»
0.0
BnaA02g07940D (rape) hypothetical
protein (BnaA02g07940D protein)		 Brassica napus
TI:3708 None
 
A0A078IZT6_BRANA
euHCVdb»
0.0
BnaA10g29400D (rape) hypothetical
protein (BnaA10g29400D protein)		 Brassica napus
TI:3708 None
 
A0A078J9M9_BRANA
neXtProt»
0.0
BnaCnng39770D (rape) hypothetical
protein (BnaCnng39770D protein)		 Brassica napus
TI:3708 None
 
M4CEP7_BRACM
EnsemblPlants»
0.0
Uncharacterized protein Brassica campestris
TI:3711 None
   
M4DV54_BRACM
EnsemblPlants»
0.0
Uncharacterized protein Brassica campestris
TI:3711 None
   
A8XXP4_CAEBR
WormBase»
0.0
tads-1 Replication termination factor 2 (Replication
termination factor 2 domain-containing protein 1)		 Caenorhabditis briggsae
TI:6238 None
 
O02209_CAEEL
WormBase»
0.0
tads-1 Replication termination factor 2 (Replication
termination factor 2 domain-containing protein 1)		 Caenorhabditis elegans
TI:6239 None
 
Q5AA12_CANAL
CGD»
0.0
CAALFM_C105800CA orf19.10009 Replication termination factor 2 Candida albicans
TI:5476 None
 
A0A8I3Q6G3_CANLF
Ensembl»
0.0
RTF2 Replication termination factor 2 (Replication
termination factor 2 domain-containing protein 1)		 Canis lupus
TI:9612 None 		     
A0A1U8H8L2_CAPAN
neXtProt»
0.0
T459_18889 Ubiquitin-like domain-containing protein Capsicum annuum
TI:4072 None
 
A0A2K3CPX4_CHLRE
euHCVdb»
0.0
CHLRE_17g715950v5 Replication termination factor 2 Chlamydomonas reinhardtii
TI:3055 None
 
A0A2K3DVP6_CHLRE
euHCVdb»
0.0
CHLRE_03g150650v5 Ubiquitin-like domain-containing protein Chlamydomonas reinhardtii
TI:3055 None
 
F6W7H5_CIOIN
Ensembl»
0.0
Replication termination factor 2 (Replication
termination factor 2 domain-containing protein 1)		 Ciona intestinalis
TI:7719 None
   
A0A067EW88_CITSI
euHCVdb»
0.0
CISIN_1g017480mg Uncharacterized protein Citrus sinensis
TI:2711 None
 
Q5K8P8_CRYD1
TubercuList»
0.0
CNL04920 Uncharacterized protein Cryptococcus deneoformans
TI:40410 None
 
A0A0A0LTI5_CUCSA
euHCVdb»
0.0
Csa_1G269330 Uncharacterized protein Cucumis sativus
TI:3659 None
 
Q7ZW03_DANRE
ZFIN»
0.0
rtf2 Replication termination factor 2 (Replication
termination factor 2 domain-containing protein 1)		 Danio rerio
TI:7955 None 		 
 
F0ZVT8_DICPU
TubercuList»
0.0
DICPUDRAFT_39155 Uncharacterized protein Dictyostelium purpureum
TI:5786 None
 
RTF2_DICDI
dictyBase»
0.0
rtf2 Replication termination factor 2 (RTF2) (Replication
termination factor 2 domain-containing protein 1)		 Dictyostelium discoideum
TI:44689 None
 
Q9VKR2_DROME
FlyBase»
0.0
Dmel\CG6443 Replication termination factor 2 (Replication
termination factor 2 domain-containing protein 1)		 Drosophila melanogaster
TI:7227 None
 
C4M3Q9_ENTH1
TubercuList»
0.0
EHI_146160 Uncharacterized protein Entamoeba histolytica
TI:5759 None
 
C4M5W0_ENTH1
TubercuList»
0.0
EHI_026320 Uncharacterized protein Entamoeba histolytica
TI:5759 None
 
A0A9L0TC73_HORSE
Ensembl»
0.0
RTF2 Replication termination factor 2 (Replication
termination factor 2 domain-containing protein 1)		 Equus caballus
TI:9796 None
   
D8FGB7_EREGS
euHCVdb»
0.0
AGOS_ADL356CA ADL356C-Ap Eremothecium gossypii
TI:33169 None
 
A0A022QFN0_ERYGU
euHCVdb»
0.0
MIMGU_mgv1a009079mg Uncharacterized protein Erythranthe guttata
TI:4155 None
 
F1NU37_CHICK
Ensembl»
0.0
RTFDC1 Replication termination factor 2 (Replication
termination factor 2 domain-containing protein 1)		 Gallus gallus
TI:9031 None
   
RTF2_CHICK
TubercuList»
1.5
RTF2 Replication termination factor 2 (RTF2) (Protein RTF2
homolog) (Replication termination factor 2 domain-containing protein 1)		 Gallus gallus
TI:9031 None
 
I1MT36_SOYBN
EnsemblPlants»
0.0
LOC100790159 Uncharacterized protein Glycine max
TI:3847 None
 
K7K9Q4_SOYBN
EnsemblPlants»
0.0
LOC100779501 Uncharacterized protein Glycine max
TI:3847 None
 
G3QNM7_GORGO
Ensembl»
0.0
RTF2 Replication termination factor 2 (Replication
termination factor 2 domain-containing protein 1)		 Gorilla gorilla
TI:9593 None
 
A0A1U8HPU4_GOSHI
neXtProt»
0.0
LOC107888434 Replication termination factor 2 Gossypium hirsutum
TI:3635 None
   
A0A1U8IC85_GOSHI
euHCVdb»
0.0
LOC107893426 Replication termination factor 2 Gossypium hirsutum
TI:3635 None
   
A0A1U8LW89_GOSHI
euHCVdb»
0.0
LOC107931409 Replication termination factor 2 Gossypium hirsutum
TI:3635 None
   
A0ABM3ADS9_GOSHI
euHCVdb»
0.0
LOC107953799 Uncharacterized protein Gossypium hirsutum
TI:3635 None
   
A0A251SQB2_HELAN
euHCVdb»
0.0
HannXRQ_Chr13g0397631 HanXRQr2_Chr13g0581501 Ubiquitin domain, replication termination
factor 2, Ubiquitin-like domain superfamily		 Helianthus annuus
TI:4232 None
 
A0A251TWZ6_HELAN
euHCVdb»
0.0
HannXRQ_Chr09g0262911 Putative zinc finger, RING/FYVE/PHD-type,
Replication termination factor 2, RING-finger		 Helianthus annuus
TI:4232 None 		 
 
A0A9K3N938_HELAN
neXtProt»
0.0
HanXRQr2_Chr09g0395601 Replication termination factor 2 Helianthus annuus
TI:4232 None
 
T1EI72_HELRO
EnsemblMetazoa»
0.0
20196272 Replication termination factor 2 (Replication
termination factor 2 domain-containing protein 1)		 Helobdella robusta
TI:6412 None
 
RTF2_HUMAN
Ensembl»
2.4
RTF2 Replication termination factor 2 (RTF2) (Replication
termination factor 2 domain-containing protein 1)		 Homo sapiens
TI:9606 None
 
A0A287VWF9_HORVV
EnsemblPlants»
0.0
LOC123407660 Uncharacterized protein Hordeum vulgare
TI:4513 None
   
B7PPK9_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW006698 Replication termination factor 2 (Replication
termination factor 2 domain-containing protein 1)		 Ixodes scapularis
TI:6945 None
 
A0A2I4H2E8_JUGRE
euHCVdb»
0.0
LOC109012894 Replication termination factor 2 Juglans regia
TI:51240 None
   
A0A1Y1HND2_KLENI
neXtProt»
0.0
KFL_000320310 Uncharacterized protein Klebsormidium nitens
TI:105231 None
 
A0A1Y1I4U6_KLENI
euHCVdb»
0.0
KFL_001590140 Rtf2 domain containing protein Klebsormidium nitens
TI:105231 None
 
A0A9R1X6M0_LACSA
euHCVdb»
0.0
LSAT_V11C600313350 Ubiquitin-like domain-containing protein Lactuca sativa
TI:4236 None
 
Q4Q5N7_LEIMA
TubercuList»
0.0
LMJF_32_0473 Replication termination factor 2 Leishmania major
TI:5664 None
 
W5MJ83_LEPOC
Ensembl»
0.0
Replication termination factor 2 (Replication
termination factor 2 domain-containing protein 1)		 Lepisosteus oculatus
TI:7918 None
 
F7HJW9_MACMU
Ensembl»
0.0
RTF2 Replication termination factor 2 (Replication
termination factor 2 domain-containing protein 1)		 Macaca mulatta
TI:9544 None
 
A0A2C9UKD1_MANES
euHCVdb»
0.0
MANES_14G111500v8 Uncharacterized protein Manihot esculenta
TI:3983 None
 
A0A2R6X0W5_MARPO
euHCVdb»
0.0
MARPO_0043s0023 Ubiquitin-like domain-containing protein Marchantia polymorpha
TI:3197 None
 
G7JGT3_MEDTR
EnsemblPlants»
0.0
MTR_4g131190 Replication termination factor 2 Medicago truncatula
TI:3880 None
 
A0A5F8H315_MONDO
Ensembl»
0.0
RTF2 Replication termination factor 2 (Replication
termination factor 2 domain-containing protein 1)		 Monodelphis domestica
TI:13616 None
   
A9V2K6_MONBE
euHCVdb»
0.0
MONBRDRAFT_26511 Uncharacterized protein Monosiga brevicollis
TI:81824 None
 
RTF2_MOUSE
Ensembl»
3.0
Rtf2 Replication termination factor 2 (RTF2) (Replication
termination factor 2 domain-containing protein 1)		 Mus musculus
TI:10090 None
 
A0A804KZQ2_MUSAM
EnsemblPlants»
0.0
GSMUA_326780.1 (wild Malaysian banana) hypothetical protein Musa acuminata
TI:4641 None
 
A0A1U8B834_NELNU
euHCVdb»
0.0
LOC104610706 Protein RTF2 homolog Nelumbo nucifera
TI:4432 None
   
A7RZE6_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g164493 Replication termination factor 2 (Replication
termination factor 2 domain-containing protein 1)		 Nematostella vectensis
TI:45351 None
 
Q7S6V8_NEUCR
TubercuList»
0.0
NCU05607 DUF602 domain-containing protein Neurospora crassa
TI:5141 None
 
A0A1S4C2V6_TOBAC
neXtProt»
0.0
LOC107814563 Protein RTF2 homolog
(Uncharacterized protein LOC107814563)		 Nicotiana tabacum
TI:4097 None
   
A0A1S4CWN0_TOBAC
euHCVdb»
0.0
LOC107823415 Protein RTF2 homolog
(Uncharacterized protein LOC107823415)		 Nicotiana tabacum
TI:4097 None
   
F7F055_ORNAN
Ensembl»
0.0
RTF2 Replication termination factor 2 (Replication
termination factor 2 domain-containing protein 1)		 Ornithorhynchus anatinus
TI:9258 None
   
Q5SMK9_ORYSJ
neXtProt»
0.0
Os06g0183900 Os06g0183900 protein (cDNA
clone:006-207-D12, full insert sequence)		 Oryza sativa
TI:4530 None
 
H2LNY9_ORYLA
Ensembl»
0.0
RTF2 Replication termination factor 2 (Replication
termination factor 2 domain-containing protein 1)		 Oryzias latipes
TI:8090 None
   
H2QKM3_PANTR
Ensembl»
0.0
RTF2 Replication termination factor 2 (Replication
termination factor 2 domain-containing protein 1)		 Pan troglodytes
TI:9598 None
 
A0DTQ1_PARTE
neXtProt»
0.0
GSPATT00020100001 Uncharacterized protein Paramecium tetraurelia
TI:5888 None
 
A0E1J7_PARTE
neXtProt»
0.0
GSPATT00022334001 Uncharacterized protein Paramecium tetraurelia
TI:5888 None
 
A0A7U2ETA6_PHANO
TubercuList»
0.0
JI435_083590 Replication termination factor 2 Phaeosphaeria nodorum
TI:13684 None 		 
 
A0A7I4AQI7_PHYPA
EnsemblPlants»
0.0
LOC112291921 Ubiquitin-like domain-containing protein Physcomitrium patens
TI:3218 None
 
H3HDX2_PHYRM
EnsemblProtists»
0.0
Uncharacterized protein Phytophthora ramorum
TI:164328 None
 
Q8I2P0_PLAF7
TubercuList»
0.0
PF3D7_0926900 Replication termination factor, putative Plasmodium falciparum
TI:5833 None
 
A0A2K1WZ89_POPTR
euHCVdb»
0.0
POPTR_018G109800 Ubiquitin-like domain-containing protein Populus trichocarpa
TI:3694 None
 
A0A2K2A4E1_POPTR
euHCVdb»
0.0
POPTR_006G186900 Ubiquitin-like domain-containing protein Populus trichocarpa
TI:3694 None
 
A0A2A6CCF5_PRIPA
EnsemblMetazoa»
0.0
WBGene00098823 Replication termination factor 2 (Replication
termination factor 2 domain-containing protein 1)		 Pristionchus pacificus
TI:54126 None
   
M5VW12_PRUPE
euHCVdb»
0.0
PRUPE_7G260500 Ubiquitin-like domain-containing protein Prunus persica
TI:3760 None
 
E3K1G4_PUCGT
TubercuList»
0.0
PGTG_04095 Replication termination factor 2 Puccinia graminis
TI:5297 None
 
RTF2_RAT
RGD»
3.0
Rtf2 Replication termination factor 2 (RTF2) (Replication
termination factor 2 domain-containing protein 1)		 Rattus norvegicus
TI:10116 None
 
B9SBX7_RICCO
euHCVdb»
0.0
RCOM_0700320 Ubiquitin-like domain-containing protein Ricinus communis
TI:3988 None
 
B6JX70_SCHJY
TubercuList»
0.0
rtf2 Replication termination factor Rtf2 Schizosaccharomyces japonicus
TI:4897 None
 
RTF2_SCHPO
PomBase»
2.4
rtf2 Splicing factor rtf2 Schizosaccharomyces pombe
TI:4896 None
 
A7F5R8_SCLS1
TubercuList»
0.0
SS1G_12946 Uncharacterized protein Sclerotinia sclerotiorum
TI:5180 None
 
D8SRW8_SELML
euHCVdb»
0.0
SELMODRAFT_46144 Uncharacterized protein Selaginella moellendorffii
TI:88036 None
 
D8T219_SELML
neXtProt»
0.0
SELMODRAFT_46143 Uncharacterized protein Selaginella moellendorffii
TI:88036 None
 
K3XWY0_SETIT
EnsemblPlants»
0.0
Uncharacterized protein Setaria italica
TI:4555 None
 
A0A3Q7HZA9_SOLLC
EnsemblPlants»
0.0
Ubiquitin-like domain-containing protein Solanum lycopersicum
TI:4081 None
   
M0ZUB0_SOLTU
EnsemblPlants»
0.0
LOC107059939 Ubiquitin-like domain-containing protein Solanum tuberosum
TI:4113 None
   
C5Z5I3_SORBI
euHCVdb»
0.0
SORBI_3010G065400 Uncharacterized protein Sorghum bicolor
TI:4558 None
 
A0A9R0I7N7_SPIOL
neXtProt»
0.0
LOC110784094 Ubiquitin-like domain-containing protein Spinacia oleracea
TI:3562 None
   
A0A7M7SXV4_STRPU
EnsemblMetazoa»
0.0
Replication termination factor 2 (Replication
termination factor 2 domain-containing protein 1)		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A4X1UPR2_PIG
Ensembl»
0.0
RTF2 Replication termination factor 2 (Replication
termination factor 2 domain-containing protein 1)		 Sus scrofa
TI:9823 None
   
RTF2_PIG
CTD»
0.0
RTF2 Replication termination factor 2 (RTF2) (Replication
termination factor 2 domain-containing protein 1)		 Sus scrofa
TI:9823 None
 
B8LC80_THAPS
neXtProt»
0.0
THAPSDRAFT_8849 Replication termination factor 2 Thalassiosira pseudonana
TI:35128 None
 
A0A061GJI9_THECC
euHCVdb»
0.0
TCM_037082 Ubiquitin-like domain-containing protein Theobroma cacao
TI:3641 None
 
D6W881_TRICA
CTD»
0.0
AUGUSTUS-3.0.2_01733 Replication termination factor 2 (Replication
termination factor 2 domain-containing protein 1)		 Tribolium castaneum
TI:7070 None
 
D6X2M7_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_12475 Replication termination factor 2 (Replication
termination factor 2 domain-containing protein 1)		 Tribolium castaneum
TI:7070 None
 
A2FJ49_TRIV3
TubercuList»
0.0
TVAG_428590 Uncharacterized protein Trichomonas vaginalis
TI:5722 None 		 
 
B3S2N1_TRIAD
CTD»
0.0
TRIADDRAFT_58086 Replication termination factor 2 (Replication
termination factor 2 domain-containing protein 1)		 Trichoplax adhaerens
TI:10228 None
 
A0A3B6SEB3_WHEAT
EnsemblPlants»
0.0
LOC123155648 Uncharacterized protein Triticum aestivum
TI:4565 None
   
A0A3B6SIE3_WHEAT
EnsemblPlants»
0.0
Uncharacterized protein Triticum aestivum
TI:4565 None
   
A0A3B6TFD7_WHEAT
EnsemblPlants»
0.0
LOC123166049 Uncharacterized protein Triticum aestivum
TI:4565 None
   
Q388D9_TRYB2
TubercuList»
0.0
Tb10.61.2030 Replication termination factor 2 Trypanosoma brucei
TI:5691 None
 
F6HYI7_VITVI
neXtProt»
0.0
VIT_11s0037g00090 Ubiquitin-like domain-containing protein Vitis vinifera
TI:29760 None
 
A0A1B8Y5J8_XENTR
Xenbase»
0.0
rtf2 Replication termination factor 2 (Replication
termination factor 2 domain-containing protein 1)		 Xenopus tropicalis
TI:8364 None
 
A0A1L8ELJ9_XENLA
Xenbase»
0.0
rtf2.S Replication termination factor 2 (Replication
termination factor 2 domain-containing protein 1)		 Xenopus laevis
TI:8355 None
   
Q6C2P1_YARLI
TubercuList»
0.0
YALI0_F06270g YALI0F06270p Yarrowia lipolytica
TI:4952 None
 
A0A804NG31_MAIZE
EnsemblPlants»
0.0
Uncharacterized protein Zea mays
TI:4577 None 		     
A0A0K9NRT8_ZOSMR
euHCVdb»
0.0
ZOSMA_69G00090 Uncharacterized protein Zostera marina
TI:29655 None