Collated Gene Ontology terms

Biological process: membrane insertase activity(2020, 2022, 2025) transmembrane transporter activity(2025)

Molecular function: protein insertion into ER membrane by stop-transfer membrane-anchor sequence2020, 2024, 2025 tail-anchored membrane protein insertion into ER membrane2020, 2022, 2024, 2025 protein folding in endoplasmic reticulum2019, 2025 transmembrane transport2025 protein insertion into ER membrane2020 phospholipid transport2024 phospholipid metabolic process2024

Cellular component: EMC complex2012, 2017, 2020, 2024, 2025 endoplasmic reticulum membrane2020, 2024, 2025 endoplasmic reticulum2009, 2014, 2018, 2021, 2025 membrane2012, 2025 protein-containing complex2018, 2025 plasma membrane2021 plant-type vacuole2021 nuclear envelope2025 endomembrane system2014 chloroplast2018
Golgi apparatus2021

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 15/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 2/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 39/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
W1NS17_AMBTC
neXtProt»
0.0
AMTR_s00109p00121860 ER membrane protein complex subunit 1 Amborella trichopoda
TI:13333 None
 
A0A803SMM0_ANOCA
Ensembl»
0.0
ER membrane protein complex subunit 1 Anolis carolinensis
TI:28377 None
   
Q5TT42_ANOGA
EnsemblMetazoa»
0.0
1274314 ER membrane protein complex subunit 1 Anopheles gambiae
TI:7165 None
 
F4JXW9_ARATH
TAIR»
0.0
At5g11560 ER membrane protein complex subunit 1 Arabidopsis thaliana
TI:3702 None
 
Q4WUQ2_ASPFU
TubercuList»
0.0
AFUA_5G09270 ER membrane protein complex subunit 1 Aspergillus fumigatus
TI:746128 None
 
F4P4D9_BATDJ
euHCVdb»
0.0
BATDEDRAFT_89405 EMC1 first
beta-propeller domain-containing protein		 Batrachochytrium dendrobatidis
TI:109871 None
 
F4P4E0_BATDJ
neXtProt»
0.0
BATDEDRAFT_89083 ER membrane protein complex subunit 1 Batrachochytrium dendrobatidis
TI:109871 None
 
A0A3Q1M901_BOVIN
Ensembl»
0.0
EMC1 ER membrane protein complex subunit 1 Bos taurus
TI:9913 None
   
I1HKT4_BRADI
EnsemblPlants»
0.0
LOC100839696 ER membrane protein complex subunit 1 Brachypodium distachyon
TI:15368 None
 
A0A9J7L739_BRAFL
euHCVdb»
0.0
LOC118415936 ER membrane protein complex subunit 1 Branchiostoma floridae
TI:7739 None
   
A0A078JRD8_BRANA
euHCVdb»
0.0
BnaCnng57230D BnaCnng57230D protein Brassica napus
TI:3708 None
 
A0A078JSY4_BRANA
euHCVdb»
0.0
BnaCnng59410D ER membrane protein complex subunit 1 Brassica napus
TI:3708 None
 
M4CPG8_BRACM
EnsemblPlants»
0.0
ER membrane protein complex subunit 1 Brassica campestris
TI:3711 None
   
M4CXK6_BRACM
EnsemblPlants»
0.0
ER membrane protein complex subunit 1 Brassica campestris
TI:3711 None
   
M4E3H8_BRACM
EnsemblPlants»
0.0
ER membrane protein complex subunit 1 Brassica campestris
TI:3711 None
   
A8X3R8_CAEBR
WormBase»
0.0
emc-1 ER membrane protein complex subunit 1 Caenorhabditis briggsae
TI:6238 None
 
H2L0C0_CAEEL
WormBase»
0.0
emc-1 ER membrane protein complex subunit 1 Caenorhabditis elegans
TI:6239 None
 
A0A1D8PN56_CANAL
CGD»
0.0
CAALFM_C501410CA orf19.11608 ER membrane protein complex subunit 1 Candida albicans
TI:5476 None
 
A0A8I3RRF6_CANLF
Ensembl»
0.0
EMC1 ER membrane protein complex subunit 1 Canis lupus
TI:9612 None
   
A0A2G2ZBI1_CAPAN
neXtProt»
0.0
T459_17410 ER membrane protein complex subunit 1 Capsicum annuum
TI:4072 None
 
A0A2K3E7I4_CHLRE
euHCVdb»
0.0
CHLRE_01g042550v5 ER membrane protein complex subunit 1 Chlamydomonas reinhardtii
TI:3055 None
 
H2Y0W0_CIOIN
Ensembl»
0.0
LOC100177708 ER membrane protein complex subunit 1 Ciona intestinalis
TI:7719 None
   
A0A067GJ73_CITSI
neXtProt»
0.0
CISIN_1g002016mg ER membrane protein complex subunit 1 Citrus sinensis
TI:2711 None
 
Q5KEQ0_CRYD1
TubercuList»
0.0
CNF04690 ER membrane protein complex subunit 1 Cryptococcus deneoformans
TI:40410 None
 
A0A0A0LS33_CUCSA
neXtProt»
0.0
Csa_2G375170 ER membrane protein complex subunit 1 Cucumis sativus
TI:3659 None
 
A0A8M9PDY1_DANRE
ZFIN»
0.0
emc1 ER membrane protein complex subunit 1 Danio rerio
TI:7955 None
   
E9GF57_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_211018 ER membrane protein complex subunit 1 Daphnia pulex
TI:6669 None
 
F0ZNI9_DICPU
TubercuList»
0.0
DICPUDRAFT_34933 ER membrane protein complex subunit 1 Dictyostelium purpureum
TI:5786 None
 
Q552B8_DICDI
dictyBase»
0.0
DDB_G0276243 ER membrane protein complex subunit 1 Dictyostelium discoideum
TI:44689 None
 
Q9VHY6_DROME
FlyBase»
2.8
EMC1 ER membrane protein complex subunit 1 Drosophila melanogaster
TI:7227 None
 
Q5B402_EMENI
TubercuList»
0.0
ANIA_04728 ER membrane protein complex subunit 1 Emericella nidulans
TI:162425 None
 
C4LWD8_ENTH1
TubercuList»
0.0
EHI_096250 ER membrane protein complex subunit 1 Entamoeba histolytica
TI:5759 None
 
F6U072_HORSE
Ensembl»
0.0
EMC1 ER membrane protein complex subunit 1 Equus caballus
TI:9796 None
   
Q751V5_EREGS
euHCVdb»
0.0
AGOS_AFR720W ER membrane protein complex subunit 1 Eremothecium gossypii
TI:33169 None
 
A0A022RNC5_ERYGU
neXtProt»
0.0
MIMGU_mgv1a000799mg ER membrane protein complex subunit 1 Erythranthe guttata
TI:4155 None
 
A0ABI7ZPV3_FELCA
Ensembl»
0.0
EMC1 ER membrane protein complex subunit 1 Felis catus
TI:9685 None
   
A0A8V0ZEQ3_CHICK
Ensembl»
0.0
EMC1 ER membrane protein complex subunit 1 Gallus gallus
TI:9031 None
   
EMC1_CHICK
CTD»
1.5
EMC1 ER membrane protein complex subunit 1 Gallus gallus
TI:9031 None
 
I1JUT9_SOYBN
EnsemblPlants»
0.0
LOC100807708 ER membrane protein complex subunit 1 Glycine max
TI:3847 None
 
I1K9B8_SOYBN
EnsemblPlants»
0.0
LOC100790095 ER membrane protein complex subunit 1 Glycine max
TI:3847 None
 
G3QE37_GORGO
Ensembl»
0.0
EMC1 ER membrane protein complex subunit 1 Gorilla gorilla
TI:9593 None
 
A0A1U8IYC1_GOSHI
euHCVdb»
0.0
LOC107901545 ER membrane protein complex subunit 1 Gossypium hirsutum
TI:3635 None
   
A0A1U8MI50_GOSHI
neXtProt»
0.0
LOC107937971 ER membrane protein complex subunit 1 Gossypium hirsutum
TI:3635 None
   
A0ABM2YL95_GOSHI
neXtProt»
0.0
LOC107944095 ER membrane protein complex subunit 1 Gossypium hirsutum
TI:3635 None
   
A0ABM2ZFV3_GOSHI
neXtProt»
0.0
LOC107893415 ER membrane protein complex subunit 1 Gossypium hirsutum
TI:3635 None
   
A0ABM3AJH8_GOSHI
euHCVdb»
0.0
LOC121220022 ER membrane protein complex subunit 1 Gossypium hirsutum
TI:3635 None
   
A0ABM3BXH0_GOSHI
euHCVdb»
0.0
LOC107962887 ER membrane protein complex subunit 1 Gossypium hirsutum
TI:3635 None
   
A0A251U7I1_HELAN
neXtProt»
0.0
HannXRQ_Chr08g0221151 HanXRQr2_Chr12g0555271 ER membrane protein complex subunit 1 Helianthus annuus
TI:4232 None
 
T1G4P4_HELRO
EnsemblMetazoa»
0.0
20216042 ER membrane protein complex subunit 1 Helobdella robusta
TI:6412 None
 
EMC1_HUMAN
Ensembl»
3.2
EMC1 ER membrane protein complex subunit 1 Homo sapiens
TI:9606 None
 
F2D6F2_HORVV
EnsemblPlants»
0.0
LOC123428688 ER membrane protein complex subunit 1 Hordeum vulgare
TI:4513 None
 
B7PJJ4_IXOSC
EnsemblMetazoa»
0.0
8029887 ER membrane protein complex subunit 1 Ixodes scapularis
TI:6945 None
 
A0A2I4GFA7_JUGRE
neXtProt»
0.0
LOC109007375 ER membrane protein complex subunit 1 Juglans regia
TI:51240 None
   
A0A2I4GNQ6_JUGRE
euHCVdb»
0.0
LOC109009503 ER membrane protein complex subunit 1 Juglans regia
TI:51240 None
   
A0A1Y1ID68_KLENI
euHCVdb»
0.0
KFL_004680080 ER membrane protein complex subunit 1 Klebsormidium nitens
TI:105231 None
 
A0A9R1V5Y4_LACSA
euHCVdb»
0.0
LSAT_V11C600324890 ER membrane protein complex subunit 1 Lactuca sativa
TI:4236 None
 
Q4Q2C8_LEIMA
TubercuList»
0.0
LMJF_34_4130 ER membrane protein complex subunit 1 Leishmania major
TI:5664 None
 
W5MAJ0_LEPOC
Ensembl»
0.0
ER membrane protein complex subunit 1 Lepisosteus oculatus
TI:7918 None
 
F7FSE2_MACMU
Ensembl»
0.0
EMC1 ER membrane protein complex subunit 1 Macaca mulatta
TI:9544 None
   
A0A2C9W525_MANES
euHCVdb»
0.0
MANES_03G061800v8 ER membrane protein complex subunit 1 Manihot esculenta
TI:3983 None
 
A0A2R6XV44_MARPO
neXtProt»
0.0
MARPO_0001s0045 ER membrane protein complex subunit 1 Marchantia polymorpha
TI:3197 None
 
A0A072V1X3_MEDTR
EnsemblPlants»
0.0
MTR_3g110090 ER membrane protein complex subunit 1 Medicago truncatula
TI:3880 None
 
A0A072V2Z0_MEDTR
EnsemblPlants»
0.0
25490115 ER membrane protein complex subunit 1 Medicago truncatula
TI:3880 None
 
F7BRB3_MONDO
Ensembl»
0.0
EMC1 ER membrane protein complex subunit 1 Monodelphis domestica
TI:13616 None
   
A9UPJ8_MONBE
euHCVdb»
0.0
MONBRDRAFT_30835 ER membrane protein complex subunit 1 Monosiga brevicollis
TI:81824 None
 
EMC1_MOUSE
Ensembl»
3.0
Emc1 ER membrane protein complex subunit 1 Mus musculus
TI:10090 None
 
A0A804ILM9_MUSAM
EnsemblPlants»
0.0
GSMUA_111560.1 ER membrane protein complex subunit 1 Musa acuminata
TI:4641 None
 
A0A804IP65_MUSAM
EnsemblPlants»
0.0
GSMUA_118210.1 ER membrane protein complex subunit 1 Musa acuminata
TI:4641 None
 
A0A1U7ZJA4_NELNU
neXtProt»
0.0
LOC104595143 ER membrane protein complex subunit 1 Nelumbo nucifera
TI:4432 None
   
A7RNR6_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g234273 ER membrane protein complex subunit 1 Nematostella vectensis
TI:45351 None
 
A7T4B3_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g145387 ER membrane protein complex subunit 1 Nematostella vectensis
TI:45351 None
 
Q7SI37_NEUCR
TubercuList»
0.0
NCU00614 ER membrane protein complex subunit 1 Neurospora crassa
TI:5141 None
 
A0A1S4AJ77_TOBAC
euHCVdb»
0.0
LOC107798297 ER membrane protein complex subunit 1 Nicotiana tabacum
TI:4097 None
   
A0A1S4BHD6_TOBAC
euHCVdb»
0.0
LOC107808270 ER membrane protein complex subunit 1 Nicotiana tabacum
TI:4097 None
   
A0A1S4CC66_TOBAC
euHCVdb»
0.0
LOC107817260 ER membrane protein complex subunit 1 Nicotiana tabacum
TI:4097 None
   
F7C0Z3_ORNAN
Ensembl»
0.0
EMC1 ER membrane protein complex subunit 1 Ornithorhynchus anatinus
TI:9258 None
   
Q75GB3_ORYSJ
neXtProt»
0.0
Os05g0230600 ER membrane protein complex subunit 1 Oryza sativa
TI:4530 None
 
H2LGW1_ORYLA
Ensembl»
0.0
EMC1 ER membrane protein complex subunit 1 Oryzias latipes
TI:8090 None
   
H2R9E3_PANTR
Ensembl»
0.0
EMC1 ER membrane protein complex subunit 1 Pan troglodytes
TI:9598 None
 
A0BUA3_PARTE
euHCVdb»
0.0
GSPATT00032352001 ER membrane protein complex subunit 1 Paramecium tetraurelia
TI:5888 None
 
A0CJK9_PARTE
euHCVdb»
0.0
GSPATT00000688001 ER membrane protein complex subunit 1 Paramecium tetraurelia
TI:5888 None
 
A0E6E8_PARTE
euHCVdb»
0.0
GSPATT00003730001 ER membrane protein complex subunit 1 Paramecium tetraurelia
TI:5888 None
 
A0A7U2HVX2_PHANO
TubercuList»
0.0
JI435_095460 ER membrane protein complex subunit 1 Phaeosphaeria nodorum
TI:13684 None
 
A9SFI2_PHYPA
EnsemblPlants»
0.0
LOC112276735 ER membrane protein complex subunit 1 Physcomitrium patens
TI:3218 None
 
H3GWY1_PHYRM
EnsemblProtists»
0.0
ER membrane protein complex subunit 1 Phytophthora ramorum
TI:164328 None
 
Q8IAU7_PLAF7
TubercuList»
0.0
PF3D7_0811200 ER membrane protein complex subunit 1 Plasmodium falciparum
TI:5833 None
 
A0A2K1WVJ7_POPTR
euHCVdb»
0.0
POPTR_018G041650v4 ER membrane protein complex subunit 1 Populus trichocarpa
TI:3694 None
 
A0A2K2A7D7_POPTR
euHCVdb»
0.0
POPTR_006G240300 ER membrane protein complex subunit 1 Populus trichocarpa
TI:3694 None
 
A0A8R1Z5I5_PRIPA
EnsemblMetazoa»
0.0
WBGene00304454 ER membrane protein complex subunit 1 Pristionchus pacificus
TI:54126 None
   
A0A251RD06_PRUPE
neXtProt»
0.0
PRUPE_1G450600 ER membrane protein complex subunit 1 Prunus persica
TI:3760 None
 
E3KH97_PUCGT
TubercuList»
0.0
PGTG_09385 ER membrane protein complex subunit 1 Puccinia graminis
TI:5297 None
 
D4A994_RAT
RGD»
1.5
Emc1 ER membrane protein complex subunit 1 Rattus norvegicus
TI:10116 None
   
B9RS37_RICCO
euHCVdb»
0.0
RCOM_0802660 ER membrane protein complex subunit 1 Ricinus communis
TI:3988 None
 
EMC1_YEAST
SGD»
3.7
EMC1 ER membrane protein complex subunit 1 Saccharomyces cerevisiae
TI:4932 None
 
B6K2G8_SCHJY
TubercuList»
0.0
emc1 ER membrane protein complex subunit 1 Schizosaccharomyces japonicus
TI:4897 None
 
EMC1_SCHPO
PomBase»
1.5
emc1 ER membrane protein complex subunit 1 Schizosaccharomyces pombe
TI:4896 None
 
A7ED32_SCLS1
TubercuList»
0.0
SS1G_03221 ER membrane protein complex subunit 1 Sclerotinia sclerotiorum
TI:5180 None
 
D8QUF2_SELML
neXtProt»
0.0
SELMODRAFT_165412 ER membrane protein complex subunit 1 Selaginella moellendorffii
TI:88036 None
 
D8R415_SELML
neXtProt»
0.0
SELMODRAFT_84520 ER membrane protein complex subunit 1 Selaginella moellendorffii
TI:88036 None
 
K3Z3H2_SETIT
EnsemblPlants»
0.0
LOC101757400 ER membrane protein complex subunit 1 Setaria italica
TI:4555 None
 
A0A3Q7HWY2_SOLLC
EnsemblPlants»
0.0
ER membrane protein complex subunit 1 Solanum lycopersicum
TI:4081 None
   
M1AZN8_SOLTU
EnsemblPlants»
0.0
LOC102580852 ER membrane protein complex subunit 1 Solanum tuberosum
TI:4113 None
   
C5YV63_SORBI
euHCVdb»
0.0
SORBI_3009G084900 ER membrane protein complex subunit 1 Sorghum bicolor
TI:4558 None
 
A0A9R0HRA9_SPIOL
neXtProt»
0.0
LOC110775256 ER membrane protein complex subunit 1 Spinacia oleracea
TI:3562 None
   
A0A7M7NXZ4_STRPU
EnsemblMetazoa»
0.0
ER membrane protein complex subunit 1 Strongylocentrotus purpuratus
TI:7668 None
   
A0A5G2QQ04_PIG
Ensembl»
0.0
EMC1 ER membrane protein complex subunit 1 Sus scrofa
TI:9823 None
   
B8C9T9_THAPS
euHCVdb»
0.0
THAPSDRAFT_24233 ER membrane protein complex subunit 1 Thalassiosira pseudonana
TI:35128 None
 
A0A061GJM6_THECC
euHCVdb»
0.0
TCM_037167 ER membrane protein complex subunit 1 Theobroma cacao
TI:3641 None
 
D6WIT7_TRICA
neXtProt»
0.0
AUGUSTUS-3.0.2_02407 ER membrane protein complex subunit 1 Tribolium castaneum
TI:7070 None
 
B3S0A1_TRIAD
CTD»
0.0
TRIADDRAFT_37902 ER membrane protein complex subunit 1 Trichoplax adhaerens
TI:10228 None
 
A0A3B5XX70_WHEAT
EnsemblPlants»
0.0
ER membrane protein complex subunit 1 Triticum aestivum
TI:4565 None
   
A0A3B5YUK0_WHEAT
EnsemblPlants»
0.0
LOC123116977 ER membrane protein complex subunit 1 Triticum aestivum
TI:4565 None
   
A0A3B5ZSP2_WHEAT
EnsemblPlants»
0.0
LOC123180745 ER membrane protein complex subunit 1 Triticum aestivum
TI:4565 None
   
Q57ZY7_TRYB2
TubercuList»
0.0
Tb04.5E12.1170 ER membrane protein complex subunit 1 Trypanosoma brucei
TI:5691 None
 
D7SUC3_VITVI
euHCVdb»
0.0
VIT_04s0008g03620 ER membrane protein complex subunit 1 Vitis vinifera
TI:29760 None
 
A0A8J0T8C8_XENLA
Xenbase»
0.0
emc1.L ER membrane protein complex subunit 1 Xenopus laevis
TI:8355 None
   
A0A8J0TDX4_XENLA
Xenbase»
0.0
emc1.S ER membrane protein complex subunit 1 Xenopus laevis
TI:8355 None
   
EMC1_XENLA
Xenbase»
0.0
emc1 ER membrane protein complex subunit 1 Xenopus laevis
TI:8355 None
 
F6TUQ9_XENTR
Xenbase»
0.0
emc1 ER membrane protein complex subunit 1 Xenopus tropicalis
TI:8364 None
   
Q6C5W6_YARLI
TubercuList»
0.0
YALI0_E14575g ER membrane protein complex subunit 1 Yarrowia lipolytica
TI:4952 None
 
A0A1D6FQV1_MAIZE
EnsemblPlants»
0.0
ZEAMMB73_Zm00001d010413 ER membrane protein complex subunit 1 Zea mays
TI:4577 None
 
A0A1D6M0B8_MAIZE
EnsemblPlants»
0.0
LOC100381974 ER membrane protein complex subunit 1 Zea mays
TI:4577 None
 
A0A0K9P6R7_ZOSMR
euHCVdb»
0.0
ZOSMA_38G00010 EMC1 first
beta-propeller domain-containing protein		 Zostera marina
TI:29655 None
 
A0A0K9Q1W9_ZOSMR
neXtProt»
0.0
ZOSMA_126G00130 ER membrane protein complex subunit 1 Zostera marina
TI:29655 None