Collated Gene Ontology terms

Biological process: RNA binding(2017, 2025) RNA helicase activity(2025) translation initiation factor activity(2023, 2025) nucleotide binding(2025) nucleic acid binding(2025) hydrolase activity(2025) helicase activity(2025) ATP binding(2025) mRNA binding(2025) ubiquitin binding(2017)

Molecular function: mRNA export from nucleus2009, 2021, 2024, 2025 protein ubiquitination2010, 2024, 2025 negative regulation of abscisic acid-activated signaling pathway2010, 2025 mRNA transport2025 mRNA processing2025 RNA splicing2025 apoptotic process2025 central nervous system development2013, 2025 translational initiation2025 translation2025
transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery2017 ta-siRNA processing2010 regulatory ncRNA-mediated gene silencing2010 piRNA processing2024 mRNA export from nucleus in response to heat stress2016 cytoplasmic translational initiation2023 abscisic acid-activated signaling pathway2025 RNA export from nucleus2020

Cellular component: THO complex2009, 2011, 2014, 2022, 2025 transcription export complex2009, 2016, 2021, 2025 nucleus2010, 2013, 2025 nuclear speck2024, 2025 Cul4-RING E3 ubiquitin ligase complex2008, 2025 nucleoplasm2015, 2024, 2025 chromosome, telomeric region2016, 2025 THO complex part of transcription export complex2009, 2025 nuclear pore2025 nuclear body2025
mitochondrion2019 cytoplasmic stress granule2023 cytoplasm2018

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 0/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 0/4 
Harosa: 2/4 
Hacrobia: 0/0 
Plants: 34/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
U5D4W4_AMBTC
euHCVdb»
0.0
AMTR_s00036p00200680 Uncharacterized protein Amborella trichopoda
TI:13333 None
 
H9GGC4_ANOCA
Ensembl»
0.0
thoc6 Uncharacterized protein Anolis carolinensis
TI:28377 None
   
Q7Q794_ANOGA
EnsemblMetazoa»
0.0
1276126 AGAP005429-PA Anopheles gambiae
TI:7165 None
 
THOC6_ARATH
TAIR»
3.7
THO6 THO complex subunit 6 (AtTHO6) (Protein DWD
HYPERSENSITIVE TO ABA 1) (WD repeat-containing protein DWA1)		 Arabidopsis thaliana
TI:3702 None
 
A0A3Q1MZJ3_BOVIN
Ensembl»
0.0
THOC6 WD repeat-containing protein 58 Bos taurus
TI:9913 None
   
A0A0Q3EUM8_BRADI
EnsemblPlants»
0.0
LOC100825336 Uncharacterized protein Brachypodium distachyon
TI:15368 None
 
A0A9J7M0T0_BRAFL
euHCVdb»
0.0
LOC118425952 THO complex subunit 6 homolog Branchiostoma floridae
TI:7739 None
   
A0A078J9L3_BRANA
euHCVdb»
0.0
BnaA07g36010D BnaA07g36010D protein Brassica napus
TI:3708 None
 
A0A078JNG9_BRANA
euHCVdb»
0.0
BnaCnng52800D BnaCnng52800D protein Brassica napus
TI:3708 None
 
M4FD32_BRACM
EnsemblPlants»
0.0
Uncharacterized protein Brassica campestris
TI:3711 None
   
A0A8I3MJX0_CANLF
Ensembl»
0.0
Uncharacterized protein Canis lupus
TI:9612 None
   
A0A8I3MPA7_CANLF
Ensembl»
0.0
THOC6 WD repeat-containing protein 58 Canis lupus
TI:9612 None
   
A0A2K3DXR5_CHLRE
euHCVdb»
0.0
CHLRE_03g180200v5 Uncharacterized protein Chlamydomonas reinhardtii
TI:3055 None
 
F6PM95_CIOIN
Ensembl»
0.0
Uncharacterized protein Ciona intestinalis
TI:7719 None
 
A0A067EDS4_CITSI
euHCVdb»
0.0
CISIN_1g0236432mg Uncharacterized protein Citrus sinensis
TI:2711 None 		 
 
A0A067EH67_CITSI
euHCVdb»
0.0
CISIN_1g0236431mg Uncharacterized protein Citrus sinensis
TI:2711 None 		 
 
A0A0A0LWJ2_CUCSA
euHCVdb»
0.0
Csa_1G589670 Uncharacterized protein Cucumis sativus
TI:3659 None
 
THOC6_DANRE
ZFIN»
0.5
thoc6 THO complex subunit 6
homolog (WD repeat-containing protein 58)		 Danio rerio
TI:7955 None
 
E9G522_DAPPU
neXtProt»
0.0
DAPPUDRAFT_314241 Uncharacterized protein Daphnia pulex
TI:6669 None
 
F0ZS40_DICPU
TubercuList»
0.0
DICPUDRAFT_80975 Uncharacterized protein Dictyostelium purpureum
TI:5786 None
 
Q54K59_DICDI
dictyBase»
0.5
thoc6 WD40 repeat-containing protein Dictyostelium discoideum
TI:44689 None
 
THOC6_DROME
FlyBase»
2.7
thoc6 THO complex subunit 6 Drosophila melanogaster
TI:7227 None
 
A0A9L0RKE2_HORSE
Ensembl»
0.0
THOC6 THO complex subunit 6 Equus caballus
TI:9796 None
   
A0A022QI57_ERYGU
euHCVdb»
0.0
MIMGU_mgv1a008589mg Uncharacterized protein Erythranthe guttata
TI:4155 None
 
A0ABI7WWL0_FELCA
Ensembl»
0.0
THOC6 THO complex 6 Felis catus
TI:9685 None 		     
A0A8V0XD98_CHICK
Ensembl»
0.0
LOC121108727 THO complex 6 Gallus gallus
TI:9031 None 		     
A0A0R0L4P0_SOYBN
EnsemblPlants»
0.0
GLYMA_02G198600 Uncharacterized protein Glycine max
TI:3847 None 		 
 
I1LY15_SOYBN
EnsemblPlants»
0.0
LOC100820024 Uncharacterized protein Glycine max
TI:3847 None
 
K7MK24_SOYBN
EnsemblPlants»
0.0
LOC100806423 Uncharacterized protein Glycine max
TI:3847 None
 
G3QR25_GORGO
Ensembl»
0.0
THOC6 WD repeat-containing protein 58 Gorilla gorilla
TI:9593 None
 
A0A1U8ISY4_GOSHI
euHCVdb»
0.0
LOC107899953 THO complex subunit 6 Gossypium hirsutum
TI:3635 None
   
A0ABM3BVZ1_GOSHI
neXtProt»
0.0
LOC107895807 THO complex subunit 6 isoform X1 Gossypium hirsutum
TI:3635 None
   
A0A251TRZ5_HELAN
neXtProt»
0.0
DWA1 Putative DWD (DDB1-binding WD40
protein) hypersensitive to ABA 1		 Helianthus annuus
TI:4232 None
 
A0A9K3I1Z2_HELAN
neXtProt»
0.0
HanXRQr2_Chr10g0465741 Transcription factor WD40-like family Helianthus annuus
TI:4232 None
 
T1FGP6_HELRO
EnsemblMetazoa»
0.0
20207995 Uncharacterized protein Helobdella robusta
TI:6412 None 		 
 
THOC6_HUMAN
Ensembl»
2.7
THOC6 THO complex subunit 6 (Functional spliceosome-associated
protein 35) (fSAP35) (WD repeat-containing protein 58)		 Homo sapiens
TI:9606 None
 
F2EHY8_HORVV
EnsemblPlants»
0.0
LOC123395025 Predicted protein Hordeum vulgare
TI:4513 None
 
B7PZH3_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW020194 THO complex subunit 6 homolog Ixodes scapularis
TI:6945 None 		 
 
A0A6P9ESY1_JUGRE
neXtProt»
0.0
LOC109009115 RNA helicase (EC 3.6.4.13) Juglans regia
TI:51240 None
   
A0A9R1VFZ1_LACSA
neXtProt»
0.0
LSAT_V11C500280200 Uncharacterized protein Lactuca sativa
TI:4236 None
 
W5LVJ1_LEPOC
Ensembl»
0.0
THO complex 6 Lepisosteus oculatus
TI:7918 None
   
F7DB82_MACMU
Ensembl»
0.0
THOC6 WD repeat-containing protein 58 Macaca mulatta
TI:9544 None
 
A0A2C9W4A9_MANES
euHCVdb»
0.0
MANES_03G036200v8 THO complex subunit 6 Manihot esculenta
TI:3983 None
 
A0A2R6WEN0_MARPO
euHCVdb»
0.0
MARPO_0100s0025 Uncharacterized protein Marchantia polymorpha
TI:3197 None
 
A0A072UT23_MEDTR
EnsemblPlants»
0.0
25494213 WD repeat protein DWA1 Medicago truncatula
TI:3880 None
 
F6ZDJ6_MONDO
Ensembl»
0.0
THOC6 WD repeat-containing protein 58 Monodelphis domestica
TI:13616 None
   
THOC6_MOUSE
Ensembl»
2.0
Thoc6 THO complex subunit 6
homolog (WD repeat-containing protein 58)		 Mus musculus
TI:10090 None
 
A0A804KAR6_MUSAM
EnsemblPlants»
0.0
GSMUA_86550.1 (wild Malaysian banana) hypothetical protein Musa acuminata
TI:4641 None
 
A0A1U8Q745_NELNU
neXtProt»
0.0
LOC104600806 RNA helicase (EC 3.6.4.13) Nelumbo nucifera
TI:4432 None
   
A7SWJ5_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g135342 THO complex subunit 6 homolog Nematostella vectensis
TI:45351 None
 
A0A1S3YLZ2_TOBAC
euHCVdb»
0.0
LOC107777567 THO complex subunit 6 Nicotiana tabacum
TI:4097 None
   
A0A6I8P1D4_ORNAN
Ensembl»
0.0
THOC6 WD repeat-containing protein 58 Ornithorhynchus anatinus
TI:9258 None
   
Q6K4E0_ORYSJ
euHCVdb»
0.0
Os09g0363600 Os09g0363600 protein (cDNA
clone:J013119F12, full insert sequence)		 Oryza sativa
TI:4530 None
 
A0A3B3I5Y2_ORYLA
Ensembl»
0.0
THOC6 THO complex 6 Oryzias latipes
TI:8090 None
   
H2QAF1_PANTR
Ensembl»
0.0
THOC6 WD repeat-containing protein 58 Pan troglodytes
TI:9598 None
 
H3GDV9_PHYRM
EnsemblProtists»
0.0
Uncharacterized protein Phytophthora ramorum
TI:164328 None
 
A0A2K1ZLP8_POPTR
euHCVdb»
0.0
POPTR_007G001500 Uncharacterized protein Populus trichocarpa
TI:3694 None
 
M5VW10_PRUPE
euHCVdb»
0.0
PRUPE_7G205900 Uncharacterized protein Prunus persica
TI:3760 None
 
THOC6_RAT
RGD»
2.0
Thoc6 THO complex subunit 6
homolog (WD repeat-containing protein 58)		 Rattus norvegicus
TI:10116 None
 
B9RK89_RICCO
neXtProt»
0.0
RCOM_1047550 RNA helicase (EC 3.6.4.13) Ricinus communis
TI:3988 None
 
K4A2N0_SETIT
EnsemblPlants»
0.0
LOC101784640 Uncharacterized protein Setaria italica
TI:4555 None
 
A0A3Q7I563_SOLLC
EnsemblPlants»
0.0
LOC101264535 Uncharacterized protein Solanum lycopersicum
TI:4081 None
   
C5XAP5_SORBI
neXtProt»
0.0
SORBI_3002G181400 Uncharacterized protein Sorghum bicolor
TI:4558 None
 
A0A9R0IM09_SPIOL
euHCVdb»
0.0
LOC110791408 THO complex subunit 6 Spinacia oleracea
TI:3562 None
   
A0A7M7HLI4_STRPU
EnsemblMetazoa»
0.0
THO complex subunit 6 homolog Strongylocentrotus purpuratus
TI:7668 None
   
A0A286ZII9_PIG
Ensembl»
0.0
THOC6 WD repeat-containing protein 58 Sus scrofa
TI:9823 None
 
B5YMK9_THAPS
euHCVdb»
0.0
THAPS_6825 Uncharacterized protein Thalassiosira pseudonana
TI:35128 None
 
A0A061GTD0_THECC
euHCVdb»
0.0
TCM_037622 DWD hypersensitive to ABA 1 Theobroma cacao
TI:3641 None
 
D6X1D8_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_11605 THO complex subunit 6-like Protein Tribolium castaneum
TI:7070 None
 
B3S4N0_TRIAD
CTD»
0.0
TRIADDRAFT_59146 Uncharacterized protein Trichoplax adhaerens
TI:10228 None
 
A0A3B6KFF1_WHEAT
EnsemblPlants»
0.0
LOC123103569 Uncharacterized protein Triticum aestivum
TI:4565 None 		     
A0A3B6LLL9_WHEAT
EnsemblPlants»
0.0
Uncharacterized protein Triticum aestivum
TI:4565 None 		     
A0A3B6MQZ2_WHEAT
EnsemblPlants»
0.0
LOC123121357 Uncharacterized protein Triticum aestivum
TI:4565 None 		     
D7TCM6_VITVI
euHCVdb»
0.0
VIT_11s0016g01910 THO complex subunit 6 Vitis vinifera
TI:29760 None
 
A0A8J1LSI8_XENLA
CTD»
0.0
thoc6.L THO complex 6 L homeolog isoform X1 Xenopus laevis
TI:8355 None
   
F7BYE1_XENTR
Xenbase»
0.0
thoc6 THO complex 6 (THO complex subunit 6 homolog) Xenopus tropicalis
TI:8364 None
   
A0A1D6I353_MAIZE
EnsemblPlants»
0.0
LOC103632647 THO complex subunit 6 Zea mays
TI:4577 None
 
A0A0K9NZJ9_ZOSMR
euHCVdb»
0.0
ZOSMA_52G00460 WD repeat-containing protein DWA1 Zostera marina
TI:29655 None