Collated Gene Ontology terms

Biological process: chromatin binding(2013, 2014, 2018, 2019, 2025) DNA binding(2006, 2020, 2025) ATP-dependent topological DNA co-entrapment activity(2016, 2020, 2025) double-stranded DNA binding(2016, 2025) protein heterodimerization activity(2014)

Molecular function: sister chromatid cohesion2019, 2025 chromosome segregation2025 cell division2025 meiotic cell cycle2005, 2025 mitotic spindle assembly2020, 2025 establishment of meiotic sister chromatid cohesion2022, 2023, 2024, 2025 establishment of mitotic sister chromatid cohesion2024, 2025 mitotic sister chromatid cohesion2004, 2013, 2014, 2016, 2025 meiotic sister chromatid cohesion, centromeric2009, 2024, 2025 meiotic sister chromatid cohesion2004, 2010, 2025
synaptonemal complex assembly2003, 2016 stem cell population maintenance2012 regulation of vasculogenesis2022 regulation of hematopoietic progenitor cell differentiation2022 regulation of DNA damage checkpoint2021, 2025 protein localization to chromosome2014 mitotic sister chromatid segregation2006, 2025 mitotic sister chromatid cohesion, centromeric2024, 2025 homologous chromosome pairing at meiosis2014 double-strand break repair involved in meiotic recombination2021, 2025 chromatin looping2021, 2025 spindle attachment to meiosis I kinetochore2009 regulation of DNA-templated transcription2025 protein acetylation2004 neuron remodeling2011 mitotic cell cycle2017 meiotic sister chromatid cohesion involved in meiosis I2014 male meiosis sister chromatid cohesion2000 linear element assembly2016 homologous chromosome orientation in meiotic metaphase I2016 female meiosis sister chromatid cohesion2000

Cellular component: nucleus2003, 2005, 2009, 2016, 2017, 2018, 2024, 2025 chromatin2006, 2009, 2014, 2016, 2024, 2025 cohesin complex2010, 2017, 2019, 2023, 2025 chromosome2009, 2012, 2025 chromosome, centromeric region2012, 2025 nucleoplasm2010, 2012, 2022, 2024, 2025 nuclear matrix2017, 2025 mitotic spindle pole2017, 2025 nucleolus2007, 2024, 2025 meiotic cohesin complex2004, 2011, 2013, 2023, 2025
fibrillar center2024, 2025 nuclear body2024, 2025 synaptonemal complex2003, 2005, 2025 mitotic cohesin complex2014, 2016, 2022, 2025 condensed nuclear chromosome2004, 2007, 2013, 2014, 2025 transverse filament2005, 2025 male germ cell nucleus2008, 2025 lateral element2013, 2025 cytosol2012, 2021, 2025 condensed chromosome2006, 2024, 2025 pericentric heterochromatin2008, 2024, 2025 condensed chromosome, centromeric region2008, 2024, 2025 subtelomeric heterochromatin2011, 2025 mating-type region heterochromatin2024, 2025 cytoplasm2021, 2025 spindle pole2008 membrane2014 extracellular space2013 euchromatin2010 cilium2025

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 0/1 
Porifera: 0/0 
Choanoflagellates+: 15/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 3/4 
Harosa: 2/4 
Hacrobia: 0/0 
Plants: 37/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
SCC3_ARATH
TAIR»
3.4
SCC3 Sister-chromatid cohesion protein
3 (AtSCC3) (Stromalin protein)		 Arabidopsis thaliana
TI:3702 None
 
SCC3_CAEEL
WormBase»
5.5
scc-3 Cohesin subunit scc-3 Caenorhabditis elegans
TI:6239 None
 
A0A0R4IZR5_DANRE
ZFIN»
2.6
stag2b Cohesin subunit SA
(SCC3 homolog) (Stromal antigen)		 Danio rerio
TI:7955 None
 
A0A8M1NE13_DANRE
ZFIN»
1.0
stag2a Cohesin subunit SA
(SCC3 homolog) (Stromal antigen)		 Danio rerio
TI:7955 None
 
A0ACD6B6N8_DANRE
ZFIN»
0.0
stag1b Cohesin subunit SA-1 Danio rerio
TI:7955 None 		     
B0S5T4_DANRE
ZFIN»
1.0
si:ch211-269e2.1 Cohesin subunit SA
(SCC3 homolog) (Stromal antigen)		 Danio rerio
TI:7955 None
 
F1QNA7_DANRE
ZFIN»
2.6
stag1a Cohesin subunit SA
(SCC3 homolog) (Stromal antigen)		 Danio rerio
TI:7955 None
 
Q54QR0_DICDI
dictyBase»
1.0
DDB_G0283681 STAG domain-containing protein Dictyostelium discoideum
TI:44689 None
 
Q9VM62_DROME
FlyBase»
5.6
SA1 LD34181p (Stromalin) Drosophila melanogaster
TI:7227 None
 
Q9W0F4_DROME
FlyBase»
1.0
SA2 Stromalin 2 Drosophila melanogaster
TI:7227 None
 
A0A8V0X6A7_CHICK
Ensembl»
1.0
STAG3 Cohesin subunit SA
(SCC3 homolog) (Stromal antigen)		 Gallus gallus
TI:9031 None
   
A0A8V0YJI9_CHICK
Ensembl»
1.0
STAG2 Cohesin subunit SA
(SCC3 homolog) (Stromal antigen)		 Gallus gallus
TI:9031 None
   
A0A8V0ZXE1_CHICK
Ensembl»
0.0
STAG1 Cohesin subunit SA
(SCC3 homolog) (Stromal antigen)		 Gallus gallus
TI:9031 None
   
ST3L1_HUMAN
AG»
0.0
STAG3L1 Putative STAG3-like protein 1
(Stromal antigen 3-like protein 1)		 Homo sapiens
TI:9606 None
 
ST3L2_HUMAN
AG»
0.0
STAG3L2 Putative STAG3-like protein 2
(Stromal antigen 3-like protein 2)		 Homo sapiens
TI:9606 None
 
ST3L3_HUMAN
AG»
0.0
STAG3L3 STAG3-like protein 3 (Stromal
antigen 3-like protein 3)		 Homo sapiens
TI:9606 None
 
ST3L4_HUMAN
AG»
0.0
STAG3L4 Putative STAG3-like protein 4
(Stromal antigen 3-like protein 4)		 Homo sapiens
TI:9606 None 		 
 
STAG1_HUMAN
Ensembl»
2.4
STAG1 Cohesin subunit SA-1 (SCC3
homolog 1) (Stromal antigen 1)		 Homo sapiens
TI:9606 None
 
STAG2_HUMAN
Ensembl»
3.2
STAG2 Cohesin subunit SA-2 (SCC3
homolog 2) (Stromal antigen 2)		 Homo sapiens
TI:9606 None
 
STAG3_HUMAN
Ensembl»
3.8
STAG3 Cohesin subunit SA-3 (SCC3 homolog
3) (Stromal antigen 3) (Stromalin-3)		 Homo sapiens
TI:9606 None
 
STAG1_MOUSE
Ensembl»
2.3
Stag1 Cohesin subunit SA-1 (SCC3
homolog 1) (Stromal antigen 1)		 Mus musculus
TI:10090 None
 
STAG2_MOUSE
Ensembl»
4.1
Stag2 Cohesin subunit SA-2 (SCC3
homolog 2) (Stromal antigen 2)		 Mus musculus
TI:10090 None
 
STAG3_MOUSE
Ensembl»
5.1
Stag3 Cohesin subunit SA-3 (SCC3 homolog
3) (Stromal antigen 3) (Stromalin-3)		 Mus musculus
TI:10090 None
 
A0A8I6ADB5_RAT
RGD»
2.0
Stag1 Cohesin subunit SA
(SCC3 homolog) (Stromal antigen)		 Rattus norvegicus
TI:10116 None
   
D3ZXT2_RAT
RGD»
3.0
Stag2 Cohesin subunit SA
(SCC3 homolog) (Stromal antigen)		 Rattus norvegicus
TI:10116 None
   
STAG3_RAT
RGD»
4.4
Stag3 Cohesin subunit SA-3 (SCC3 homolog
3) (Stromal antigen 3) (Stromalin-3)		 Rattus norvegicus
TI:10116 None
 
SCC3_YEAST
SGD»
4.6
IRR1 Cohesin subunit SCC3 (Irregular
cell behavior protein 1)		 Saccharomyces cerevisiae
TI:4932 None
 
REC11_SCHPO
PomBase»
4.7
rec11 Meiotic recombination protein rec11 Schizosaccharomyces pombe
TI:4896 None
 
SCC3_SCHPO
PomBase»
8.0
psc3 Cohesin subunit psc3 (SCC3 homolog) Schizosaccharomyces pombe
TI:4896 None