Collated Gene Ontology terms

Biological process: sulfiredoxin activity(2005, 2013, 2022, 2023, 2025) oxidoreductase activity(2025) nucleotide binding(2025) antioxidant activity(2025) ATP binding(2025) oxidoreductase activity, acting on a sulfur group of donors(2005, 2007, 2025)

Molecular function: cellular response to oxidative stress2005, 2013, 2017, 2025 cellular oxidant detoxification2022, 2025 response to oxidative stress2005, 2007, 2025 negative regulation of protein polymerization2016, 2025

Cellular component: cytoplasm2018, 2020, 2025 cytosol2005, 2009, 2022, 2025 nucleus2009, 2018, 2025 chloroplast2012, 2018, 2025 mitochondrion2012, 2025 endoplasmic reticulum membrane2022

Phylogenetic distribution

Chordates: 20/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 0/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 4/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 7/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 1/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 39/39 
Archea: 0/8 
Bacteria: 1/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
SRXN1_MOUSE
Ensembl»
3.6
Srxn1 Sulfiredoxin-1 (EC 1.8.98.2)
(Neoplastic progression protein 3)		 Mus musculus
TI:10090 None
 
SRX1_YEAST
SGD»
3.4
SRX1 Sulfiredoxin (EC 1.8.98.2) (Sulphiredoxin) Saccharomyces cerevisiae
TI:4932 None
 
SRXN1_HUMAN
Ensembl»
3.5
SRXN1 Sulfiredoxin-1 (EC 1.8.98.2) Homo sapiens
TI:9606 None
 
SRX1_SCHPO
PomBase»
2.6
srx1 Sulfiredoxin (EC 1.8.98.2) Schizosaccharomyces pombe
TI:4896 None
 
SRX_ARATH
TAIR»
2.6
SRX Sulfiredoxin, chloroplastic/mitochondrial
(AtSRX) (EC 1.8.98.2)		 Arabidopsis thaliana
TI:3702 None
 
Q59ZI2_CANAL
CGD»
0.0
CAALFM_C205060CA orf19.11021 Sulfiredoxin (EC 1.8.98.2) Candida albicans
TI:5476 None
 
Q759X0_EREGS
neXtProt»
0.0
AGOS_ADR152CA Sulfiredoxin (EC 1.8.98.2) Eremothecium gossypii
TI:33169 None
 
Q7TP44_RAT
RGD»
2.0
Srxn1 Sulfiredoxin-1 (EC 1.8.98.2) Rattus norvegicus
TI:10116 None
 
A0A1L8EM31_XENLA
euHCVdb»
0.0
LOC108702679 Sulfiredoxin (EC 1.8.98.2) Xenopus laevis
TI:8355 None
   
A0A1L8ETB1_XENLA
CTD»
0.0
LOC108700963 Sulfiredoxin (EC 1.8.98.2) Xenopus laevis
TI:8355 None
   
A0A3Q2UDS8_CHICK
Ensembl»
1.0
SRXN1 Sulfiredoxin-1 (EC 1.8.98.2) Gallus gallus
TI:9031 None
   
A0A6I8PBI0_ORNAN
Ensembl»
0.0
SRXN1 Sulfiredoxin (EC 1.8.98.2) Ornithorhynchus anatinus
TI:9258 None
   
A0A8I3NX66_CANLF
Ensembl»
0.0
SRXN1 Sulfiredoxin (EC 1.8.98.2) Canis lupus
TI:9612 None
   
F1S862_PIG
Ensembl»
0.0
SRXN1 Sulfiredoxin (EC 1.8.98.2) Sus scrofa
TI:9823 None
   
F6VCF5_MONDO
Ensembl»
0.0
SRXN1 Sulfiredoxin-1 (EC 1.8.98.2) Monodelphis domestica
TI:13616 None
   
F7H9B2_MACMU
Ensembl»
0.0
SRXN1 Sulfiredoxin (EC 1.8.98.2) Macaca mulatta
TI:9544 None
 
G3RKU5_GORGO
Ensembl»
0.0
SRXN1 Sulfiredoxin-1 (EC 1.8.98.2) Gorilla gorilla
TI:9593 None
 
K7CJI6_PANTR
Ensembl»
0.0
SRXN1 Sulfiredoxin-1 (EC 1.8.98.2) Pan troglodytes
TI:9598 None
 
SRX_DROME
FlyBase»
2.6
Srx Sulfiredoxin (EC 1.8.98.2) Drosophila melanogaster
TI:7227 None
 
A0A1S3XFY6_TOBAC
neXtProt»
0.0
LOC107764730 sulfiredoxin (EC 1.8.98.2) Nicotiana tabacum
TI:4097 None
   
A0A1S3YGX8_TOBAC
neXtProt»
0.0
LOC107776142 sulfiredoxin (EC 1.8.98.2) Nicotiana tabacum
TI:4097 None
   
A0A1U8LLE4_GOSHI
neXtProt»
0.0
LOC107928688 sulfiredoxin (EC 1.8.98.2) Gossypium hirsutum
TI:3635 None
   
A0A9R0I7Z6_SPIOL
neXtProt»
0.0
LOC110784360 sulfiredoxin (EC 1.8.98.2) Spinacia oleracea
TI:3562 None
   
Q6C8V4_YARLI
TubercuList»
0.0
YALI0_D16709g Sulfiredoxin (EC 1.8.98.2) Yarrowia lipolytica
TI:4952 None
 
A0A3B3HLV1_ORYLA
Ensembl»
0.0
SRXN1 Sulfiredoxin-1 (EC 1.8.98.2) Oryzias latipes
TI:8090 None
   
A0A7M7G1N1_STRPU
EnsemblMetazoa»
0.0
sulfiredoxin (EC 1.8.98.2) Strongylocentrotus purpuratus
TI:7668 None
   
A0A8J1IYI9_XENTR
Xenbase»
0.0
srxn1 Sulfiredoxin (EC 1.8.98.2) Xenopus tropicalis
TI:8364 None
   
A0A9J7MWU5_BRAFL
euHCVdb»
0.0
LOC118419255 Sulfiredoxin-1 (EC 1.8.98.2) Branchiostoma floridae
TI:7739 None
   
A7RL34_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g198676 Sulfiredoxin (EC 1.8.98.2) Nematostella vectensis
TI:45351 None
 
A7RMU5_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g87155 Sulfiredoxin (EC 1.8.98.2) Nematostella vectensis
TI:45351 None
 
B6K600_SCHJY
TubercuList»
0.0
srx1 Sulfiredoxin (EC 1.8.98.2) Schizosaccharomyces japonicus
TI:4897 None
 
D6WAJ2_TRICA
neXtProt»
0.0
AUGUSTUS-3.0.2_01167 Sulfiredoxin (EC 1.8.98.2) Tribolium castaneum
TI:7070 None
 
E9HFZ8_DAPPU
neXtProt»
0.0
DAPPUDRAFT_62353 Sulfiredoxin (EC 1.8.98.2) Daphnia pulex
TI:6669 None
 
E9HG05_DAPPU
neXtProt»
0.0
DAPPUDRAFT_329227 Sulfiredoxin (EC 1.8.98.2) Daphnia pulex
TI:6669 None
 
E9HJN6_DAPPU
neXtProt»
0.0
DAPPUDRAFT_63423 DAPPUDRAFT_70136 Sulfiredoxin (EC 1.8.98.2) Daphnia pulex
TI:6669 None
 
F0ZSX9_DICPU
TubercuList»
0.0
DICPUDRAFT_12802 sulfiredoxin (EC 1.8.98.2) Dictyostelium purpureum
TI:5786 None
 
F6WIH5_CIOIN
Ensembl»
0.0
Sulfiredoxin (EC 1.8.98.2) Ciona intestinalis
TI:7719 None
 
W5M2J1_LEPOC
Ensembl»
0.0
Sulfiredoxin-1 (EC 1.8.98.2) Lepisosteus oculatus
TI:7918 None
 
A0A022RUL1_ERYGU
neXtProt»
0.0
MIMGU_mgv1a015075mg sulfiredoxin (EC 1.8.98.2) Erythranthe guttata
TI:4155 None
 
A0A061DVT4_THECC
neXtProt»
0.0
TCM_006053 Sulfiredoxin (EC 1.8.98.2) Theobroma cacao
TI:3641 None
 
A0A067GPK3_CITSI
neXtProt»
0.0
CISIN_1g033111mg sulfiredoxin (EC 1.8.98.2) Citrus sinensis
TI:2711 None
 
A0A078FHH0_BRANA
neXtProt»
0.0
BnaC08g09260D sulfiredoxin (EC 1.8.98.2) Brassica napus
TI:3708 None
 
A0A078GPB1_BRANA
neXtProt»
0.0
BnaA08g07990D Sulfiredoxin (EC 1.8.98.2) Brassica napus
TI:3708 None
 
A0A0A0LYK6_CUCSA
neXtProt»
0.0
Csa_1G701390 Sulfiredoxin (EC 1.8.98.2) Cucumis sativus
TI:3659 None
 
A0A0K9NQQ2_ZOSMR
neXtProt»
0.0
ZOSMA_71G00040 sulfiredoxin (EC 1.8.98.2) Zostera marina
TI:29655 None
 
A0A1U8A0Z8_NELNU
neXtProt»
0.0
LOC104599677 sulfiredoxin (EC 1.8.98.2) Nelumbo nucifera
TI:4432 None
   
A0A1Y1HXX4_KLENI
neXtProt»
0.0
KFL_001500250 sulfiredoxin (EC 1.8.98.2) Klebsormidium nitens
TI:105231 None
 
A0A251T684_HELAN
neXtProt»
0.0
HannXRQ_Chr12g0381571 HanXRQr2_Chr12g0557091 Sulfiredoxin (EC 1.8.98.2) Helianthus annuus
TI:4232 None
 
A0A2C9U985_MANES
neXtProt»
0.0
MANES_16G055800v8 Sulfiredoxin (EC 1.8.98.2) Manihot esculenta
TI:3983 None
 
A0A2G3A6L9_CAPAN
neXtProt»
0.0
T459_04946 sulfiredoxin (EC 1.8.98.2) Capsicum annuum
TI:4072 None
 
A0A2I4G0B1_JUGRE
neXtProt»
0.0
LOC109003588 Sulfiredoxin (EC 1.8.98.2) Juglans regia
TI:51240 None
   
A0A2K1KBU4_PHYPA
EnsemblPlants»
0.0
LOC112284903 sulfiredoxin (EC 1.8.98.2) Physcomitrium patens
TI:3218 None
 
A0A2K1YCP6_POPTR
neXtProt»
0.0
POPTR_012G124500 sulfiredoxin (EC 1.8.98.2) Populus trichocarpa
TI:3694 None
 
A0A2K3CQW5_CHLRE
neXtProt»
0.0
CHLRE_17g729950v5 sulfiredoxin (EC 1.8.98.2) Chlamydomonas reinhardtii
TI:3055 None
 
A0A2K3DRW0_CHLRE
neXtProt»
0.0
CHLRE_05g232800v5 sulfiredoxin (EC 1.8.98.2) Chlamydomonas reinhardtii
TI:3055 None
 
A0A2R6WQB6_MARPO
neXtProt»
0.0
MARPO_0066s0018 sulfiredoxin (EC 1.8.98.2) Marchantia polymorpha
TI:3197 None
 
A0A3B6RA08_WHEAT
EnsemblPlants»
0.0
sulfiredoxin (EC 1.8.98.2) Triticum aestivum
TI:4565 None
   
A0A3B6S8T4_WHEAT
EnsemblPlants»
0.0
LOC123158909 sulfiredoxin (EC 1.8.98.2) Triticum aestivum
TI:4565 None
   
A0A3B6TLQ3_WHEAT
EnsemblPlants»
0.0
sulfiredoxin (EC 1.8.98.2) Triticum aestivum
TI:4565 None
   
A0A3Q7FMG0_SOLLC
EnsemblPlants»
0.0
LOC101260008 Sulfiredoxin (EC 1.8.98.2) Solanum lycopersicum
TI:4081 None
   
A0A804HPX5_MUSAM
EnsemblPlants»
0.0
GSMUA_287510.1 sulfiredoxin (EC 1.8.98.2) Musa acuminata
TI:4641 None
 
A0A8I6YJ92_HORVV
EnsemblPlants»
0.0
LOC123409752 sulfiredoxin (EC 1.8.98.2) Hordeum vulgare
TI:4513 None
   
A0A9R1WBY2_LACSA
neXtProt»
0.0
LSAT_V11C300144870 Sulfiredoxin (EC 1.8.98.2) Lactuca sativa
TI:4236 None
 
A0AAA9ST57_BOVIN
Ensembl»
0.0
SRXN1 Sulfiredoxin (EC 1.8.98.2) Bos taurus
TI:9913 None
   
A7T8W8_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g150651 sulfiredoxin (EC 1.8.98.2) Nematostella vectensis
TI:45351 None
 
B7PI40_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW024306 sulfiredoxin (EC 1.8.98.2) Ixodes scapularis
TI:6945 None
 
B7PQR7_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW024409 sulfiredoxin (EC 1.8.98.2) Ixodes scapularis
TI:6945 None
 
B7Q5U0_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW011176 sulfiredoxin (EC 1.8.98.2) Ixodes scapularis
TI:6945 None
 
B9SCC3_RICCO
neXtProt»
0.0
RCOM_0891620 sulfiredoxin (EC 1.8.98.2) Ricinus communis
TI:3988 None
 
C5Z5B8_SORBI
neXtProt»
0.0
SORBI_3010G058200 sulfiredoxin (EC 1.8.98.2) Sorghum bicolor
TI:4558 None
 
D7T9L4_VITVI
neXtProt»
0.0
VIT_01s0011g01620 sulfiredoxin (EC 1.8.98.2) Vitis vinifera
TI:29760 None
 
D8RRA4_SELML
neXtProt»
0.0
SELMODRAFT_18837 sulfiredoxin (EC 1.8.98.2) Selaginella moellendorffii
TI:88036 None
 
D8RX69_SELML
neXtProt»
0.0
SELMODRAFT_103767 sulfiredoxin (EC 1.8.98.2) Selaginella moellendorffii
TI:88036 None
 
I1H0K3_BRADI
EnsemblPlants»
0.0
LOC100838881 sulfiredoxin (EC 1.8.98.2) Brachypodium distachyon
TI:15368 None
 
I1NDB8_SOYBN
EnsemblPlants»
0.0
GLYMA_20G019100 Sulfiredoxin (EC 1.8.98.2) Glycine max
TI:3847 None
 
K3XZQ8_SETIT
EnsemblPlants»
0.0
LOC101770539 sulfiredoxin (EC 1.8.98.2) Setaria italica
TI:4555 None
 
K7VA76_MAIZE
EnsemblPlants»
0.0
LOC100194080 sulfiredoxin (EC 1.8.98.2) Zea mays
TI:4577 None
 
M1AP37_SOLTU
EnsemblPlants»
0.0
LOC102592429 Sulfiredoxin (EC 1.8.98.2) Solanum tuberosum
TI:4113 None
   
M4FBE6_BRACM
EnsemblPlants»
0.0
sulfiredoxin (EC 1.8.98.2) Brassica campestris
TI:3711 None
   
Q2MGR0_MEDTR
EnsemblPlants»
0.0
11444056 Sulfiredoxin (EC 1.8.98.2) Medicago truncatula
TI:3880 None
 
Q45GC6_ORYSJ
neXtProt»
0.0
Os06g0174300 sulfiredoxin (EC 1.8.98.2) Oryza sativa
TI:4530 None
 
Q5KNI8_CRYD1
TubercuList»
0.0
CNA06340 sulfiredoxin (EC 1.8.98.2) Cryptococcus deneoformans
TI:40410 None
 
U5DGZ2_AMBTC
neXtProt»
0.0
AMTR_s00062p00193540 sulfiredoxin (EC 1.8.98.2) Amborella trichopoda
TI:13333 None
 
A0A1U8N9Z8_GOSHI
neXtProt»
0.0
LOC107945222 sulfiredoxin (EC 1.8.98.2) Gossypium hirsutum
TI:3635 None
   
A0ABI7Z488_FELCA
Ensembl»
0.0
SRXN1 Sulfiredoxin (EC 1.8.98.2) Felis catus
TI:9685 None
   
M5WI61_PRUPE
neXtProt»
0.0
PRUPE_4G113200 Sulfiredoxin (EC 1.8.98.2) Prunus persica
TI:3760 None
 
O66661_AQUAE
EnsemblBacteria»
0.0
aq_324 sulfiredoxin (EC 1.8.98.2) Aquifex aeolicus
TI:63363 None
 
O66789_AQUAE
EnsemblBacteria»
0.0
aq_499 sulfiredoxin (EC 1.8.98.2) Aquifex aeolicus
TI:63363 None
 
A0A3B6RE38_WHEAT
EnsemblPlants»
0.0
Sulfiredoxin Triticum aestivum
TI:4565 None
   
A0A3B6S9P9_WHEAT
EnsemblPlants»
0.0
LOC123155712 Sulfiredoxin Triticum aestivum
TI:4565 None
   
A0A3B6TEI0_WHEAT
EnsemblPlants»
0.0
LOC123170405 Sulfiredoxin Triticum aestivum
TI:4565 None
   
A0A3B6TLP8_WHEAT
EnsemblPlants»
0.0
LOC123164497 Sulfiredoxin Triticum aestivum
TI:4565 None
   
A0ACD6B5Q8_DANRE
ZFIN»
0.0
srxn1 Sulfiredoxin-1 isoform X1 Danio rerio
TI:7955 None