Collated Gene Ontology terms

Biological process: tRNA-intron endonuclease activity(2003, 2008, 2012, 2017, 2023) nucleic acid binding(2023) lyase activity(2023) endonuclease activity(2023) hydrolase activity(2023) RNA binding(2023)

Molecular function: tRNA splicing, via endonucleolytic cleavage and ligation2009, 2023 tRNA-type intron splice site recognition and cleavage2008, 2014, 2017, 2023 tRNA processing2021, 2023 mRNA processing2023 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2021 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2021 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2021 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2021

Cellular component: tRNA-intron endonuclease complex2003, 2008, 2014, 2017, 2023 nucleus2023 nucleoplasm2015, 2023 membrane2023 cytosol2023 centrosome2023 mitochondrial outer membrane2004, 2006, 2014, 2023 nucleolus2023 mitochondrion2006, 2023 endomembrane system2023
cytoplasm2009

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 1/3 
Arthropods: 4/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 15/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 0/4 
Harosa: 1/4 
Hacrobia: 0/0 
Plants: 35/39 
Archea: 8/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 0 2 4 6 8 10 Knownness

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
SEN2_YEAST
SGD»
4.2
SEN2 tRNA-splicing endonuclease subunit SEN2 (EC 4.6.1.16)
(Splicing endonuclease protein 2) (tRNA-intron endonuclease SEN2)		 Saccharomyces cerevisiae
TI:4932 None
 
SEN2_MOUSE
Ensembl»
1.5
Tsen2 tRNA-splicing endonuclease subunit Sen2
(EC 4.6.1.16) (tRNA-intron endonuclease Sen2)		 Mus musculus
TI:10090 None
 
SEN2_HUMAN
Ensembl»
1.8
TSEN2 tRNA-splicing endonuclease subunit Sen2 (EC
4.6.1.16) (tRNA-intron endonuclease Sen2) (HsSen2)		 Homo sapiens
TI:9606 None
 
SEN2_RAT
RGD»
1.5
Tsen2 tRNA-splicing endonuclease subunit Sen2
(EC 4.6.1.16) (tRNA-intron endonuclease Sen2)		 Rattus norvegicus
TI:10116 None
 
SEN2_SCHPO
PomBase»
2.0
sen2 Probable tRNA-splicing endonuclease subunit sen2
(EC 4.6.1.16) (tRNA-intron endonuclease sen2)		 Schizosaccharomyces pombe
TI:4896 None
 
Q08BW3_DANRE
ZFIN»
1.0
zgc:154067 tRNA-splicing endonuclease subunit
Sen2 (EC 4.6.1.16)		 Danio rerio
TI:7955 None
 
SEN2_CHICK
CTD»
1.0
TSEN2 tRNA-splicing endonuclease subunit Sen2
(EC 4.6.1.16) (tRNA-intron endonuclease Sen2)		 Gallus gallus
TI:9031 None
 
Q54RX5_DICDI
dictyBase»
1.0
DDB_G0282855 tRNA-splicing endonuclease subunit
Sen2 (EC 4.6.1.16)		 Dictyostelium discoideum
TI:44689 None
 
Q8IP11_DROME
FlyBase»
1.8
Tsen2 tRNA-intron lyase (EC 4.6.1.16) Drosophila melanogaster
TI:7227 None
 
SEN22_ARATH
TAIR»
1.0
SEN2 tRNA-splicing endonuclease subunit Sen2-2 (EC
4.6.1.16) (tRNA-intron endonuclease Sen2-2) (AtSen2)		 Arabidopsis thaliana
TI:3702 None
 
Q9U218_CAEEL
WormBase»
1.0
tsen-2 tRNA-intron lyase (EC 4.6.1.16) Caenorhabditis elegans
TI:6239 None
 
A0A8V1ADV8_CHICK
Ensembl»
0.0
TSEN2 tRNA-splicing endonuclease subunit
Sen2 (EC 4.6.1.16)		 Gallus gallus
TI:9031 None
   
SEN21_ARATH
TAIR»
0.0
SEN1 tRNA-splicing endonuclease subunit Sen2-1 (EC
4.6.1.16) (tRNA-intron endonuclease Sen2-1) (AtSen1)		 Arabidopsis thaliana
TI:3702 None
 
Q2V3Q6_ARATH
TAIR»
0.0
At3g45577 tRNA-intron endonuclease Arabidopsis thaliana
TI:3702 None