Collated Gene Ontology terms

Biological process: tRNA-intron lyase activity(2013, 2024, 2025) nucleic acid binding(2025) lyase activity(2025) endonuclease activity(2024, 2025) hydrolase activity(2025) zinc ion binding(2025) sequence-specific DNA binding(2025) nuclease activity(2004) nuclear receptor activity(2025) metal ion binding(2025)
RNA binding2025 DNA-binding transcription factor activity2025 DNA binding2025

Molecular function: tRNA processing2021, 2024, 2025 tRNA-type intron splice site recognition and cleavage2013, 2024, 2025 tRNA splicing, via endonucleolytic cleavage and ligation2003, 2009, 2025 mRNA processing2025 rhythmic process2025 regulation of transport2025 regulation of lipid localization2025 regulation of DNA-templated transcription2025 positive regulation of transcription by RNA polymerase II2025 negative regulation of gene expression2025
intracellular receptor signaling pathway2025 cellular response to xenobiotic stimulus2014 cellular response to hormone stimulus2025 DNA-templated transcription2025

Cellular component: tRNA-intron endonuclease complex2013, 2024, 2025 cytoplasm2009, 2025 nucleus2018, 2025 nucleoplasm2015, 2024, 2025 mitochondrial outer membrane2013, 2018, 2024, 2025 cytoplasmic side of mitochondrial outer membrane2025 nucleolus2025 mitochondrion2018 peroxisome2022 membrane2025
endomembrane system2025 cytosol2025 centrosome2025

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 1/3 
Arthropods: 4/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 14/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 1/4 
Harosa: 1/4 
Hacrobia: 0/0 
Plants: 37/39 
Archea: 8/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
Q2V3Q6_ARATH
TAIR»
1.5
At3g45577 tRNA-intron endonuclease Arabidopsis thaliana
TI:3702 None
 
SEN21_ARATH
TAIR»
1.5
SEN1 tRNA-splicing endonuclease subunit Sen2-1 (EC
4.6.1.16) (tRNA-intron endonuclease Sen2-1) (AtSen1)		 Arabidopsis thaliana
TI:3702 None
 
SEN22_ARATH
TAIR»
2.5
SEN2 tRNA-splicing endonuclease subunit Sen2-2 (EC
4.6.1.16) (tRNA-intron endonuclease Sen2-2) (AtSen2)		 Arabidopsis thaliana
TI:3702 None
 
Q9U218_CAEEL
WormBase»
1.5
tsen-2 tRNA-intron lyase (EC 4.6.1.16) Caenorhabditis elegans
TI:6239 None
 
Q08BW3_DANRE
ZFIN»
1.5
tsen2 tRNA-splicing endonuclease subunit
Sen2 (EC 4.6.1.16)		 Danio rerio
TI:7955 None
 
Q54RX5_DICDI
dictyBase»
1.5
DDB_G0282855 tRNA-splicing endonuclease subunit
Sen2 (EC 4.6.1.16)		 Dictyostelium discoideum
TI:44689 None
 
Q8IP11_DROME
FlyBase»
2.3
Tsen2 tRNA-intron lyase (EC 4.6.1.16) Drosophila melanogaster
TI:7227 None
 
A0A8V1ADV8_CHICK
Ensembl»
1.5
TSEN2 tRNA-splicing endonuclease subunit
Sen2 (EC 4.6.1.16)		 Gallus gallus
TI:9031 None
   
SEN2_CHICK
CTD»
1.5
TSEN2 tRNA-splicing endonuclease subunit Sen2
(EC 4.6.1.16) (tRNA-intron endonuclease Sen2)		 Gallus gallus
TI:9031 None
 
SEN2_HUMAN
Ensembl»
3.1
TSEN2 tRNA-splicing endonuclease subunit Sen2 (EC
4.6.1.16) (tRNA-intron endonuclease Sen2) (HsSen2)		 Homo sapiens
TI:9606 None
 
SEN2_MOUSE
Ensembl»
2.5
Tsen2 tRNA-splicing endonuclease subunit Sen2
(EC 4.6.1.16) (tRNA-intron endonuclease Sen2)		 Mus musculus
TI:10090 None
 
SEN2_RAT
RGD»
2.5
Tsen2 tRNA-splicing endonuclease subunit Sen2
(EC 4.6.1.16) (tRNA-intron endonuclease Sen2)		 Rattus norvegicus
TI:10116 None
 
SEN2_YEAST
SGD»
4.7
SEN2 tRNA-splicing endonuclease subunit SEN2 (EC 4.6.1.16)
(Splicing endonuclease protein 2) (tRNA-intron endonuclease SEN2)		 Saccharomyces cerevisiae
TI:4932 None
 
SEN2_SCHPO
PomBase»
1.5
sen2 Probable tRNA-splicing endonuclease subunit sen2
(EC 4.6.1.16) (tRNA-intron endonuclease sen2)		 Schizosaccharomyces pombe
TI:4896 None