Biological process: metalloendopeptidase activity^{(2005, 2007, 2009, 2011, 2012, 2013, 2014, 2018, 2020, 2021, 2022, 2024)} metal ion binding⁽²⁰²⁴⁾ metallopeptidase activity^{(2019, 2024)} ATP binding^{(2007, 2009, 2024)} zinc ion binding^{(2007, 2009, 2011, 2019, 2022, 2024)} mRNA binding^{(2020, 2024)} endopeptidase activity^{(2019, 2022, 2024)} protein homodimerization activity^{(2019, 2024)} insulin binding^{(2007, 2012, 2024)} peptide binding^{(2012, 2024)}
± 16 peptidase activity^{2005, 2008, 2024} protein folding chaperone^{2023, 2024} identical protein binding^{2007, 2024} virus receptor activity²⁰²⁴ protein-containing complex binding²⁰⁰⁷ protein kinase activity²⁰²⁴ peptide hormone binding²⁰⁰⁷ hydroxymethylglutaryl-CoA synthase activity²⁰²⁴ hydrolase activity, hydrolyzing O-glycosyl compounds²⁰²⁴ hydrolase activity²⁰²⁴ glycosyltransferase activity²⁰²⁴ epidermal growth factor binding²⁰⁰⁵ endo-1,4-beta-xylanase activity²⁰²⁴ beta-endorphin binding²⁰⁰⁷ amyloid-beta binding²⁰¹⁰ ATP hydrolysis activity²⁰⁰⁷

Molecular function: proteolysis^{2011, 2014, 2018, 2019, 2024} peptide catabolic process^{2005, 2017, 2019, 2024} proteolysis involved in protein catabolic process^{2007, 2017, 2019, 2024} amyloid-beta metabolic process^{2009, 2010, 2017, 2019, 2024} hormone catabolic process^{2007, 2017, 2019, 2024} embryo development ending in seed dormancy^{2011, 2024} insulin catabolic process^{2014, 2019, 2022, 2024} protein catabolic process^{2007, 2019, 2021, 2024} positive regulation of membrane protein ectodomain proteolysis^{2008, 2022, 2024} amyloid-beta clearance^{2018, 2020, 2021, 2024}
± 53 bradykinin catabolic process^{2009, 2012, 2024} antigen processing and presentation of endogenous peptide antigen via MHC class I^{2019, 2024} regulation of endopeptidase activity^{2008, 2024} amyloid-beta clearance by cellular catabolic process^{2018, 2024} peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion^{2021, 2024} ubiquitin recycling^{2012, 2024} regulation of aerobic respiration^{2018, 2024} insulin metabolic process^{2012, 2024} positive regulation of myelination²⁰²² positive regulation of axonogenesis²⁰²² negative regulation of cold-induced thermogenesis²⁰¹⁸ mitochondrial protein processing^{2021, 2023, 2024} type B pancreatic cell development^{2017, 2024} pancreas regeneration^{2017, 2024} endocrine pancreas development^{2017, 2024} vesicle-mediated transport²⁰²⁴ response to oxidative stress²⁰²⁰ pyrroloquinoline quinone biosynthetic process^{2019, 2024} insulin receptor recycling²⁰²² endoplasmic reticulum to Golgi vesicle-mediated transport²⁰²⁴ cytogamy^{2015, 2024} chaperone-mediated protein folding^{2017, 2024} axial cellular bud site selection^{2013, 2024} viral entry into host cell²⁰²⁴ ubiquitin-dependent protein catabolic process²⁰²¹ response to pheromone²⁰²⁴ response to hydrogen peroxide²⁰²¹ regulation of egg-laying behavior²⁰¹³ protein processing involved in protein targeting to mitochondrion²⁰²⁰ protein processing²⁰²¹ protein phosphorylation²⁰²⁴ positive regulation of protein catabolic process²⁰²¹ positive regulation of protein binding²⁰¹⁹ positive regulation of innate immune response²⁰¹³ piecemeal microautophagy of the nucleus²⁰²¹ negative regulation of proteolysis²⁰⁰⁷ negative regulation of insulin receptor signaling pathway²⁰¹⁹ negative regulation of growth²⁰¹³ negative regulation of developmental growth²⁰¹⁹ meiotic cell cycle²⁰²⁴ insulin receptor signaling pathway²⁰¹² filamentous growth of a population of unicellular organisms in response to starvation²⁰¹⁴ filamentous growth of a population of unicellular organisms in response to biotic stimulus²⁰¹⁴ filamentous growth²⁰¹⁴ farnesyl diphosphate biosynthetic process, mevalonate pathway²⁰²⁴ determination of adult lifespan²⁰¹³ defense response to Gram-negative bacterium²⁰¹³ cytoplasm to vacuole transport by the Cvt pathway²⁰²¹ cellular response to starvation²⁰¹⁴ carbohydrate metabolic process²⁰²⁴ autophagy of mitochondrion²⁰²¹ acetyl-CoA metabolic process²⁰²⁴ GPI anchor biosynthetic process²⁰²¹

Cellular component: mitochondrion^{2009, 2017, 2018, 2021, 2023, 2024} cytosol^{2005, 2009, 2012, 2018, 2019, 2023, 2024} membrane²⁰²⁴ peroxisomal matrix^{2007, 2017, 2024} cytoplasm^{2011, 2014, 2017, 2018, 2024} mitochondrial matrix^{2018, 2021, 2024} peroxisome^{2012, 2013, 2018, 2024} extracellular space^{2012, 2018, 2024} cell surface^{2005, 2012, 2018, 2024} plasma membrane^{2014, 2024}
± 22 periplasmic space^{2019, 2024} nucleus^{2013, 2024} external side of plasma membrane^{2018, 2024} basolateral plasma membrane^{2018, 2024} extracellular region²⁰²⁴ chloroplast^{2021, 2024} extracellular exosome²⁰¹⁸ dendrite²⁰²⁴ chloroplast stroma^{2021, 2024} cellular bud neck^{2013, 2024} cell projection²⁰²⁴ plastid²⁰¹⁹ mating projection tip^{2013, 2024} endosome lumen²⁰²² endoplasmic reticulum²⁰²⁴ ciliary plasm²⁰¹⁷ TRAPP complex²⁰²⁴ Golgi apparatus²⁰²⁴ protein folding chaperone complex²⁰¹⁷ outer membrane-bounded periplasmic space²⁰¹⁴ outer membrane²⁰¹⁹ cytosolic proteasome complex²⁰⁰⁷