Collated Gene Ontology terms

Biological process: RNA binding(2014, 2015) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(2025) metal ion binding(2025) first spliceosomal transesterification activity(2013) dioxygenase activity(2025)

Molecular function: generation of catalytic spliceosome for second transesterification step2013, 2017, 2025 mRNA 3'-splice site recognition2013, 2017 mRNA splicing, via spliceosome2006, 2010, 2011, 2019, 2025 RNA splicing2025 mRNA processing2025 mRNA cis splicing, via spliceosome2023, 2024, 2025 regulation of primary miRNA processing2019, 2025 cellular response to xenobiotic stimulus2014

Cellular component: nucleus2009, 2017, 2018, 2019, 2025 catalytic step 2 spliceosome2010, 2011, 2017, 2025 Prp19 complex2013, 2014, 2017, 2024, 2025 post-mRNA release spliceosomal complex2013, 2016, 2017, 2025 post-spliceosomal complex2013, 2017 spliceosomal complex2006, 2014, 2025 U2-type catalytic step 1 spliceosome2013, 2019, 2025 nuclear speck2024, 2025 cytoplasm2025 U2-type spliceosomal complex2025
nucleoplasm2015, 2025 cytosol2009, 2019 U2-type post-mRNA release spliceosomal complex2016, 2025 precatalytic spliceosome2010 U2-type catalytic step 2 spliceosome2013

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 2/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 14/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 3/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 39/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
A0A0N4SUM8_MOUSE
Ensembl»
0.0
Gm45140 Pre-mRNA-splicing factor ISY1 homolog Mus musculus
TI:10090 None
   
A4FUN5_DANRE
ZFIN»
1.0
isy1 Pre-mRNA-splicing factor ISY1 homolog Danio rerio
TI:7955 None
 
F1P220_CHICK
Ensembl»
1.0
ISY1 Pre-mRNA-splicing factor ISY1 homolog Gallus gallus
TI:9031 None
   
ISY1_CAEEL
WormBase»
1.8
isy-1 Protein isy-1 Caenorhabditis elegans
TI:6239 None
 
ISY1_DICDI
dictyBase»
1.5
isy1 Pre-mRNA-splicing factor ISY1 homolog Dictyostelium discoideum
TI:44689 None
 
ISY1_HUMAN
Ensembl»
3.9
ISY1 Pre-mRNA-splicing factor ISY1 homolog Homo sapiens
TI:9606 None
 
ISY1_MOUSE
Ensembl»
1.5
Isy1 Pre-mRNA-splicing factor ISY1 homolog Mus musculus
TI:10090 None
 
ISY1_RAT
RGD»
2.0
Isy1 Pre-mRNA-splicing factor ISY1 homolog Rattus norvegicus
TI:10116 None
 
ISY1_SCHPO
PomBase»
2.6
cwf12 Pre-mRNA-splicing factor cwf12 (Complexed
with cdc5 protein 12)		 Schizosaccharomyces pombe
TI:4896 None
 
ISY1_YEAST
SGD»
4.0
ISY1 Pre-mRNA-splicing factor ISY1 (Interactor of
SYF1) (PRP19-associated complex protein 30)		 Saccharomyces cerevisiae
TI:4932 None
 
Q9LS97_ARATH
TAIR»
1.0
At3g18790 At3g18790/MVE11_17 AT3G18790 protein (AT3g18790/MVE11_17)
(Pre-mRNA-splicing factor ISY1-like protein)		 Arabidopsis thaliana
TI:3702 None
 
Q9VHV6_DROME
FlyBase»
2.5
Dmel\CG9667 RE31520p (Uncharacterized protein, isoform A) Drosophila melanogaster
TI:7227 None