Collated Gene Ontology terms

Biological process: single-stranded DNA binding(2019, 2020, 2025) protein-DNA covalent cross-linking activity(2024, 2025) peptidase activity(2025) lyase activity(2025) hydrolase activity(2025) DNA binding(2025) DNA-(abasic site) binding(2023, 2024, 2025) DNA-(apurinic or apyrimidinic site) endonuclease activity(2019)

Molecular function: protein-DNA covalent cross-linking repair2023, 2024, 2025 DNA damage response2019, 2020, 2023, 2025 interstrand cross-link repair2023, 2025 proteolysis2025 double-strand break repair via alternative nonhomologous end joining2020, 2025 somatic hypermutation of immunoglobulin genes2023, 2025 positive regulation of isotype switching2020, 2025 DNA repair2025 SOS response2025 cellular response to iron ion2017

Cellular component: replication fork2023, 2025 chromosome2025 nucleus2018 cytoplasm2018

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 4/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 11/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 1/4 
Harosa: 3/4 
Hacrobia: 0/0 
Plants: 36/39 
Archea: 1/8 
Bacteria: 13/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 5 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
HMCES_HUMAN
Ensembl»
10.4
HMCES Abasic site processing protein HMCES (EC 4.-.-.-) (Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein)
(ES cell-specific 5hmC-binding protein) (Peptidase HMCES) (EC 3.4.-.-) (SRAP domain-containing protein 1)		 Homo sapiens
TI:9606 None
 
Q8GZ60_ARATH
TAIR»
3.0
At2g26470 At2g26470/T9J22.14 At2g26470 (Embryonic stem
cell-specific 5-hydroxymethylcytosine-binding protein)		 Arabidopsis thaliana
TI:3702 None
 
YEDK_ECOLI
EnsemblBacteria»
5.4
yedK Abasic site processing protein YedK
(EC 4.-.-.-) (Peptidase YedK) (EC 3.4.-.-)		 Escherichia coli
TI:562 None
 
A5PLB0_DANRE
ZFIN»
3.5
hmces Abasic site processing protein HMCES (ES cell-specific 5hmC-binding protein) (EC 3.4.-.-)
(Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein) (Peptidase HMCES) (SRAP domain-containing protein 1)		 Danio rerio
TI:7955 None
 
HMCES_MOUSE
Ensembl»
12.2
Hmces Abasic site processing protein HMCES (EC 4.-.-.-) (Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein)
(ES cell-specific 5hmC-binding protein) (Peptidase HMCES) (EC 3.4.-.-) (SRAP domain-containing protein 1)		 Mus musculus
TI:10090 None
 
Q9VHI3_DROME
FlyBase»
3.0
Dmel\CG11986 Abasic site processing protein HMCES (Embryonic stem cell-specific
5-hydroxymethylcytosine-binding protein) (Peptidase HMCES) (SRAP domain-containing protein 1)		 Drosophila melanogaster
TI:7227 None
 
YM04_YEAST
SGD»
3.0
YMR114C Abasic site processing protein YMR114C
(EC 4.-.-.-) (Peptidase YMR114C) (EC 3.4.-.-)		 Saccharomyces cerevisiae
TI:4932 None
 
HMCES_CHICK
Ensembl»
7.0
HMCES Abasic site processing protein HMCES (EC 4.-.-.-) (Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein)
(ES cell-specific 5hmC-binding protein) (Peptidase HMCES) (EC 3.4.-.-) (SRAP domain-containing protein 1)		 Gallus gallus
TI:9031 None
 
HMCES_RAT
RGD»
12.5
Hmces Abasic site processing protein HMCES (EC 4.-.-.-) (Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein)
(ES cell-specific 5hmC-binding protein) (Peptidase HMCES) (EC 3.4.-.-) (SRAP domain-containing protein 1)		 Rattus norvegicus
TI:10116 None