Biological process: chromatin binding^{(2013, 2014, 2017, 2019, 2025)} cis-regulatory region sequence-specific DNA binding^{(2024, 2025)} lncRNA binding^{(2023, 2025)} DNA-binding transcription factor binding^{(2023, 2025)} sequence-specific DNA binding^{(2012, 2025)} damaged DNA binding⁽²⁰⁰⁶⁾ DNA binding⁽²⁰²⁵⁾ ATP-dependent topological DNA co-entrapment activity^{(2021, 2024)} zinc ion binding⁽²⁰²⁵⁾ protein kinase binding⁽²⁰²²⁾
± 2 nucleic acid binding²⁰²⁵ double-stranded DNA binding²⁰¹⁶

Molecular function: sister chromatid cohesion^{2003, 2010, 2025} replication-born double-strand break repair via sister chromatid exchange^{2014, 2020, 2025} chromosome segregation²⁰²⁵ cell division^{2017, 2025} double-strand break repair^{2003, 2004, 2006, 2014, 2015, 2022, 2025} meiotic sister chromatid cohesion, centromeric^{2009, 2022, 2025} meiotic sister chromatid cohesion^{2013, 2014, 2020, 2025} mitotic sister chromatid cohesion^{2007, 2009, 2016, 2019, 2022, 2023} protein localization to chromatin^{2010, 2025} regulation of transcription by RNA polymerase II^{2010, 2012, 2025}
± 61 positive regulation of sister chromatid cohesion^{2016, 2025} negative regulation of mitotic metaphase/anaphase transition^{2016, 2025} negative regulation of G2/M transition of mitotic cell cycle^{2016, 2025} meiotic cell cycle^{2003, 2005, 2006, 2025} DNA damage response^{2013, 2016, 2025} DNA repair²⁰²⁵ synaptonemal complex assembly^{2006, 2013, 2015, 2025} establishment of mitotic sister chromatid cohesion^{2013, 2024, 2025} apoptotic process^{2013, 2025} positive regulation of gene expression^{2010, 2023, 2025} chromatin looping^{2021, 2022, 2025} spindle attachment to meiosis I kinetochore^{2009, 2021, 2024, 2025} reciprocal meiotic recombination^{2003, 2006, 2013} positive regulation of interleukin-10 production^{2023, 2025} negative regulation of tumor necrosis factor production^{2023, 2025} negative regulation of neuron apoptotic process^{2023, 2025} negative regulation of interleukin-1 beta production^{2023, 2025} negative regulation of glial cell apoptotic process^{2023, 2025} negative regulation of gene expression^{2023, 2025} homologous chromosome pairing at meiosis^{2008, 2022, 2025} establishment of meiotic sister chromatid cohesion²⁰²⁵ DNA-templated transcription²⁰²⁵ response to hypoxia^{2023, 2025} oocyte maturation^{2008, 2020} mitotic cell cycle^{2014, 2017} meiotic centromeric cohesion protection in anaphase I^{2021, 2024, 2025} spermatid development²⁰⁰⁸ seminiferous tubule development²⁰²¹ regulation of centriole-centriole cohesion^{2017, 2025} mitotic chromosome condensation^{2013, 2017} meiotic sister chromatid cohesion involved in meiosis I^{2014, 2025} meiotic chromosome movement towards spindle pole^{2007, 2025} male meiosis I²⁰⁰⁸ homologous chromosome orientation in meiotic metaphase I^{2024, 2025} fertilization²⁰¹³ enteric nervous system development²⁰¹⁵ double-strand break repair via homologous recombination²⁰²¹ ventriculo bulbo valve morphogenesis²⁰¹⁶ synaptonemal complex organization²⁰¹⁴ spermatogenesis²⁰⁰³ protein localization to chromosome, centromeric region²⁰¹³ protein acetylation²⁰⁰⁴ pollen development²⁰⁰⁷ pharyngeal system development²⁰¹⁶ neuron remodeling²⁰⁰⁹ mitotic telomere tethering at nuclear periphery²⁰¹⁷ mitotic sister chromatid segregation²⁰¹⁸ meiotic chromosome condensation²⁰⁰⁴ meiotic DNA double-strand break formation²⁰¹⁹ megagametogenesis²⁰⁰⁷ homologous recombination²⁰¹⁹ homologous chromosome segregation²⁰²⁴ heart looping²⁰¹⁶ heart development²⁰¹⁶ embryonic viscerocranium morphogenesis²⁰¹⁶ chromosome organization²⁰¹⁷ centromeric sister chromatid cohesion²⁰¹⁴ blood circulation²⁰¹⁶ atrioventricular valve morphogenesis²⁰¹⁶ G2/M transition of mitotic cell cycle²⁰²⁴ DNA recombination²⁰⁰³

Cellular component: cohesin complex^{2003, 2010, 2014, 2016, 2017, 2024, 2025} nucleus^{2003, 2006, 2009, 2011, 2013, 2014, 2016, 2017, 2018, 2023, 2024, 2025} meiotic cohesin complex^{2004, 2011, 2015, 2024, 2025} chromosome^{2011, 2013, 2017, 2025} condensed nuclear chromosome^{2006, 2013, 2014, 2019, 2025} chromosome, centromeric region^{2013, 2019, 2021, 2025} nucleoplasm^{2010, 2011, 2017, 2022, 2024, 2025} mitotic cohesin complex^{2016, 2022, 2024, 2025} chromatin^{2006, 2014, 2016, 2025} nuclear matrix^{2017, 2025}
± 21 condensed chromosome, centromeric region^{2012, 2016, 2020, 2024, 2025} synaptonemal complex^{2003, 2006, 2014, 2025} nucleolus^{2013, 2024, 2025} male germ cell nucleus^{2008, 2025} lateral element^{2005, 2022, 2025} kinetochore^{2012, 2025} condensed chromosome^{2016, 2025} cytosol^{2013, 2025} spindle pole²⁰²⁵ pericentric heterochromatin^{2014, 2018, 2025} spindle microtubule^{2017, 2025} meiotic spindle pole^{2017, 2025} meiotic spindle^{2018, 2025} cytoplasm²⁰²⁵ rDNA heterochromatin²⁰¹⁵ polytene chromosome interband²⁰⁰⁹ mitochondrion²⁰¹³ midbody²⁰²⁵ membrane²⁰¹⁴ heterochromatin island²⁰²⁰ chromosome, subtelomeric region²⁰¹⁵