Collated Gene Ontology terms

Biological process: ER retention sequence binding(2025) KDEL sequence binding(2007, 2014, 2019, 2025) HDEL sequence binding(2005, 2013, 2025) signaling receptor activity(2015)

Molecular function: protein retention in ER lumen2014, 2025 vesicle-mediated transport2025 protein transport2025 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum2019, 2021, 2024, 2025 maintenance of protein localization in endoplasmic reticulum2021, 2025 T cell differentiation2016 T cell apoptotic process2016 intracellular protein transport2007 IRE1-mediated unfolded protein response2018

Cellular component: endoplasmic reticulum membrane2005, 2013, 2015, 2019, 2022, 2025 membrane2019, 2025 endoplasmic reticulum2005, 2009, 2011, 2014, 2023, 2024, 2025 cis-Golgi network2003, 2011, 2013, 2014, 2021, 2025 Golgi membrane2015, 2019, 2025 COPI-coated vesicle membrane2019, 2025 cytoplasmic vesicle2025 Golgi apparatus2005, 2009, 2012, 2013, 2021, 2024, 2025 endoplasmic reticulum-Golgi intermediate compartment2006, 2025 endoplasmic reticulum-Golgi intermediate compartment membrane2015, 2025
transport vesicle2015 mitochondrion2018 cytoplasm2018, 2025 TRAPP complex2025

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 15/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 4/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 39/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
ERD23_HUMAN
Ensembl»
2.6
KDELR3 ER lumen protein-retaining receptor 3 (KDEL endoplasmic
reticulum protein retention receptor 3) (KDEL receptor 3)		 Homo sapiens
TI:9606 None
 
ERD21_HUMAN
Ensembl»
2.6
KDELR1 ER lumen protein-retaining receptor 1 (KDEL endoplasmic reticulum protein
retention receptor 1) (KDEL receptor 1) (Putative MAPK-activating protein PM23)		 Homo sapiens
TI:9606 None
 
ERD22_HUMAN
Ensembl»
4.2
KDELR2 ER lumen protein-retaining receptor 2 (ERD2-like protein 1) (ELP-1)
(KDEL endoplasmic reticulum protein retention receptor 2) (KDEL receptor 2)		 Homo sapiens
TI:9606 None
 
ERD22_MOUSE
Ensembl»
4.0
Kdelr2 ER lumen protein-retaining receptor 2 (KDEL endoplasmic
reticulum protein retention receptor 2) (KDEL receptor 2)		 Mus musculus
TI:10090 None
 
ERD2A_ARATH
TAIR»
1.0
ERD2A ER lumen protein-retaining
receptor A (HDEL receptor)		 Arabidopsis thaliana
TI:3702 None
 
ERD2B_ARATH
TAIR»
1.0
ERD2B ER lumen protein-retaining receptor B Arabidopsis thaliana
TI:3702 None
 
ERD2_DROME
FlyBase»
2.3
KdelR ER lumen protein-retaining receptor Drosophila melanogaster
TI:7227 None
 
ERD2_YEAST
SGD»
2.6
ERD2 ER lumen protein-retaining receptor (Endoplasmic reticulum
retention defective protein 2) (HDEL receptor)		 Saccharomyces cerevisiae
TI:4932 None
 
ERD21_MOUSE
Ensembl»
4.6
Kdelr1 ER lumen protein-retaining receptor 1 (KDEL endoplasmic
reticulum protein retention receptor 1) (KDEL receptor 1)		 Mus musculus
TI:10090 None
 
ERD23_MOUSE
Ensembl»
3.0
Kdelr3 ER lumen protein-retaining receptor 3 (KDEL endoplasmic
reticulum protein retention receptor 3) (KDEL receptor 3)		 Mus musculus
TI:10090 None
 
Q84TL5_ARATH
TAIR»
0.0
At1g75760 At1g75760 (ER lumen protein retaining receptor family
protein) (Putative ER lumen protein retaining receptor)		 Arabidopsis thaliana
TI:3702 None
 
Q8LD89_ARATH
TAIR»
0.0
At4g38790 At4g38791 ER lumen protein retaining receptor family
protein (Putative ER lumen protein retaining receptor)		 Arabidopsis thaliana
TI:3702 None
 
ERD21_CAEEL
WormBase»
1.5
erd-2.1 ER lumen protein-retaining receptor erd-2.1 Caenorhabditis elegans
TI:6239 None
 
ERD22_DANRE
ZFIN»
2.0
kdelr2 ER lumen protein-retaining receptor 2 (KDEL endoplasmic
reticulum protein retention receptor 2) (KDEL receptor 2)		 Danio rerio
TI:7955 None
 
Q5PNU5_ARATH
TAIR»
0.0
At3g25160 At3g25160 (ER lumen protein
retaining receptor family protein)		 Arabidopsis thaliana
TI:3702 None
 
Q6PH70_DANRE
ZFIN»
1.0
kdelr2b ER lumen protein-retaining receptor 2b (KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein
retention receptor 2, like) (KDEL endoplasmic reticulum protein retention receptor 2b)		 Danio rerio
TI:7955 None
 
Q9SKP4_ARATH
TAIR»
0.0
At2g21190 ER lumen protein retaining receptor family
protein (Putative ER lumen protein retaining receptor)		 Arabidopsis thaliana
TI:3702 None
 
ERD21_RAT
RGD»
4.0
Kdelr1 ER lumen protein-retaining receptor 1 (KDEL endoplasmic
reticulum protein retention receptor 1) (KDEL receptor 1)		 Rattus norvegicus
TI:10116 None
 
ERD22_CAEEL
WormBase»
0.0
erd-2.2 ER lumen protein-retaining receptor erd-2.2 Caenorhabditis elegans
TI:6239 None
 
ERD22_CHICK
CTD»
2.8
KDELR2 ER lumen protein-retaining receptor 2 (KDEL endoplasmic
reticulum protein retention receptor 2) (KDEL receptor 2)		 Gallus gallus
TI:9031 None
 
ERD22_RAT
RGD»
4.0
Kdelr2 ER lumen protein-retaining receptor 2 (KDEL endoplasmic
reticulum protein retention receptor 2) (KDEL receptor 2)		 Rattus norvegicus
TI:10116 None
 
ERD23_DANRE
ZFIN»
2.0
kdelr3 ER lumen protein-retaining receptor 3 (KDEL endoplasmic
reticulum protein retention receptor 3) (KDEL receptor 3)		 Danio rerio
TI:7955 None
 
ERD2_DICDI
dictyBase»
1.0
kdelr ER lumen protein-retaining receptor Dictyostelium discoideum
TI:44689 None
 
ERD2_SCHPO
PomBase»
3.0
erd2 ER lumen protein-retaining receptor Schizosaccharomyces pombe
TI:4896 None
 
F4HR00_ARATH
TAIR»
0.0
At1g19970 ER lumen protein
retaining receptor family protein		 Arabidopsis thaliana
TI:3702 None
 
A0A8V0YAZ3_CHICK
Ensembl»
1.0
KDELR3 ER lumen protein-retaining receptor Gallus gallus
TI:9031 None
   
A0A8V0ZA78_CHICK
Ensembl»
1.0
KDELR2 ER lumen protein-retaining receptor Gallus gallus
TI:9031 None
   
F1LPB5_RAT
RGD»
2.0
Kdelr3 ER lumen protein-retaining receptor Rattus norvegicus
TI:10116 None