Collated Gene Ontology terms

Biological process: lipoate synthase activity(2010, 2011, 2013, 2017, 2023, 2024) 4 iron, 4 sulfur cluster binding(2014, 2024) transferase activity(2017, 2024) metal ion binding(2024) structural constituent of ribosome(2024) protein kinase activity(2024) protein homodimerization activity(2014) iron-sulfur cluster binding(2024) iron ion binding(2009) ATP binding(2024)
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity2023

Molecular function: lipoate biosynthetic process2009, 2010, 2011, 2012, 2023, 2024 protein lipoylation2011, 2024 response to oxidative stress2009, 2010, 2024 response to lipopolysaccharide2009, 2010, 2024 inflammatory response2009, 2010, 2024 neural tube closure2005, 2024 translation2024 protein phosphorylation2024 protein maturation2017 photosynthesis2024
glycine catabolic process2003

Cellular component: mitochondrion2001, 2009, 2010, 2014, 2017, 2018, 2019, 2024 chloroplast2024 cytoplasm2009, 2024 mitochondrial matrix2010, 2015, 2024 kinetoplast2017 apicoplast2011, 2024 ribosome2024 ribonucleoprotein complex2024 membrane2024 large ribosomal subunit2024
cytosol2014

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 14/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 2/4 
Harosa: 3/4 
Hacrobia: 0/0 
Plants: 37/39 
Archea: 3/8 
Bacteria: 27/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
LIAS_ARATH
TAIR»
0.9
LIP1 Lipoyl synthase, mitochondrial (EC 2.8.1.8) (Lipoate synthase)
(LS) (Lip-syn) (Lipoate-protein ligase) (AtLPLA) (Lipoic acid synthase)		 Arabidopsis thaliana
TI:3702 None
 
LIAS_HUMAN
Ensembl»
3.5
LIAS Lipoyl synthase, mitochondrial (EC 2.8.1.8) (Lipoate
synthase) (LS) (Lip-syn) (Lipoic acid synthase)		 Homo sapiens
TI:9606 None
 
LIAS_MOUSE
Ensembl»
4.8
Lias Lipoyl synthase, mitochondrial (EC 2.8.1.8) (Lipoate
synthase) (LS) (Lip-syn) (mLIP1) (Lipoic acid synthase)		 Mus musculus
TI:10090 None
 
LIPA_ECOLI
EnsemblBacteria»
3.2
lipA Lipoyl synthase (EC 2.8.1.8) (Lip-syn) (LS) (Lipoate
synthase) (Lipoic acid synthase) (Sulfur insertion protein LipA)		 Escherichia coli
TI:562 None
 
LISC_ARATH
TAIR»
0.0
LIP1P Lipoyl synthase, chloroplastic (EC 2.8.1.8) (Lipoate synthase) (LS)
(Lip-syn) (Lipoate synthase, plastidial) (LIP1p) (Lipoic acid synthase)		 Arabidopsis thaliana
TI:3702 None
 
LIPA_YEAST
SGD»
1.5
LIP5 Lipoyl synthase, mitochondrial (EC 2.8.1.8) (Lipoate
synthase) (LS) (Lip-syn) (Lipoic acid synthase)		 Saccharomyces cerevisiae
TI:4932 None
 
LIAS_DROME
FlyBase»
1.0
Las Lipoyl synthase, mitochondrial (EC 2.8.1.8) (Lipoate
synthase) (LS) (Lip-syn) (Lipoic acid synthase)		 Drosophila melanogaster
TI:7227 None
 
LIPA_SCHPO
PomBase»
1.6
lip5 Lipoyl synthase, mitochondrial (EC 2.8.1.8) (Lipoate
synthase) (LS) (Lip-syn) (Lipoic acid synthase)		 Schizosaccharomyces pombe
TI:4896 None
 
LIAS_DANRE
ZFIN»
1.0
lias Lipoyl synthase, mitochondrial (EC 2.8.1.8) (Lipoate
synthase) (LS) (Lip-syn) (Lipoic acid synthase)		 Danio rerio
TI:7955 None
 
LIAS_CAEEL
WormBase»
1.0
M01F1.3 Lipoyl synthase, mitochondrial (EC 2.8.1.8) (Lipoate
synthase) (LS) (Lip-syn) (Lipoic acid synthase)		 Caenorhabditis elegans
TI:6239 None
 
LIAS_RAT
RGD»
4.0
Lias Lipoyl synthase, mitochondrial (EC 2.8.1.8) (Lipoate
synthase) (LS) (Lip-syn) (Lipoic acid synthase)		 Rattus norvegicus
TI:10116 None
 
A0A8V0YXK1_CHICK
Ensembl»
0.0
LIAS Lipoyl synthase, mitochondrial (EC 2.8.1.8) (Lipoate
synthase) (LS) (Lip-syn) (Lipoic acid synthase)		 Gallus gallus
TI:9031 None