Biological process: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity^{(2005, 2006, 2008, 2009, 2012, 2013, 2014, 2016, 2017, 2022, 2024)} DNA binding^{(2005, 2006, 2009, 2016, 2024)} ATP binding^{(2005, 2006, 2024)} DNA topoisomerase activity^{(2006, 2017, 2024)} metal ion binding⁽²⁰²⁴⁾ chromatin binding^{(2006, 2015, 2024)} magnesium ion binding^{(2012, 2024)} DNA binding, bending^{(2012, 2024)} ATP-dependent activity, acting on DNA^{(2006, 2009, 2024)} ubiquitin binding^{(2006, 2024)}
± 23 protein kinase C binding^{2006, 2024} protein homodimerization activity^{2006, 2024} protein heterodimerization activity^{2006, 2024} isomerase activity²⁰²⁴ oxidoreductase activity²⁰²⁴ identical protein binding²⁰²⁴ ribonucleoprotein complex binding^{2015, 2024} ATP hydrolysis activity^{2022, 2023} zinc ion binding²⁰²⁴ transferase activity²⁰²⁴ sequence-specific DNA binding²⁰⁰⁶ satellite DNA binding²⁰⁰⁷ rDNA binding²⁰⁰⁷ protein-lysine N-methyltransferase activity²⁰²⁴ mRNA binding²⁰⁰⁶ hydrolase activity, hydrolyzing O-glycosyl compounds²⁰²⁴ hydrolase activity, acting on glycosyl bonds²⁰²⁴ histone methyltransferase activity²⁰²⁴ histone H3 methyltransferase activity²⁰²⁴ four-way junction DNA binding²⁰⁰⁸ cyclin binding²⁰⁰⁶ RNA binding²⁰¹⁴ 2-alkenal reductase [NAD(P)+] activity²⁰²⁴

Molecular function: DNA topological change^{2005, 2006, 2007, 2008, 2009, 2012, 2013, 2014, 2015, 2017, 2020, 2024} resolution of meiotic recombination intermediates^{2015, 2017, 2024} sister chromatid segregation^{2009, 2021, 2024} apoptotic chromosome condensation^{2006, 2009, 2017, 2024} positive regulation of single stranded viral RNA replication via double stranded DNA intermediate^{2006, 2018, 2024} rhythmic process²⁰²⁴ chromosome segregation^{2004, 2006, 2009, 2024} negative regulation of DNA duplex unwinding^{2017, 2024} regulation of circadian rhythm^{2014, 2024} B cell differentiation^{2022, 2024}
± 56 meiosis I cell cycle process²⁰²⁴ positive regulation of apoptotic process^{2006, 2009, 2024} chromosome condensation^{2004, 2016, 2024} DNA ligation^{2006, 2009, 2024} DNA damage response^{2006, 2009, 2024} positive regulation of transcription by RNA polymerase II^{2006, 2024} neuron migration^{2005, 2024} hematopoietic progenitor cell differentiation^{2014, 2024} forebrain development^{2005, 2024} female meiotic nuclear division^{2016, 2024} embryonic cleavage^{2004, 2024} axonogenesis^{2002, 2024} regulation of macromolecule metabolic process²⁰²⁴ chromatin organization^{2005, 2022, 2024} telomere maintenance via recombination^{2020, 2024} retinal ganglion cell axon guidance^{2011, 2024} retina layer formation^{2011, 2024} replication fork progression beyond termination site^{2013, 2024} regulation of mitotic recombination^{2013, 2024} reciprocal meiotic recombination^{2013, 2024} rRNA transcription^{2019, 2024} neuromast development^{2021, 2024} chromatin remodeling at centromere^{2013, 2024} axon target recognition^{2011, 2024} DNA strand elongation involved in DNA replication^{2013, 2024} DNA metabolic process²⁰²⁴ positive regulation of double-strand break repair via nonhomologous end joining^{2017, 2024} mitotic chromosome condensation^{2014, 2016, 2024} cellular senescence^{2017, 2024} cellular response to hydrogen peroxide^{2017, 2024} cellular response to ATP^{2017, 2024} cell division^{2019, 2024} animal organ regeneration^{2009, 2024} mitotic sister chromatid segregation^{2014, 2018} mitotic cell cycle^{2006, 2010} meiotic cell cycle^{2006, 2024} response to xenobiotic stimulus²⁰⁰⁹ response to parathyroid hormone²⁰⁰⁹ response to ionizing radiation²⁰¹⁷ mitotic sister chromatid separation²⁰¹⁷ metaphase plate congression²⁰⁰⁹ male meiosis chromosome segregation²⁰⁰⁶ heterochromatin formation²⁰⁰⁷ filamentous growth of a population of unicellular organisms in response to starvation²⁰¹⁴ filamentous growth of a population of unicellular organisms in response to neutral pH²⁰¹⁴ filamentous growth²⁰¹⁴ female meiosis chromosome separation²⁰¹⁶ deoxyribonucleotide biosynthetic process²⁰²⁴ chromatin remodeling²⁰²⁴ cerebellar granule cell differentiation²⁰¹⁰ cerebellar Purkinje cell differentiation²⁰¹⁰ cellular response to starvation²⁰¹⁴ cellular response to neutral pH²⁰¹⁴ carbohydrate metabolic process²⁰²⁴ anatomical structure morphogenesis²⁰²⁴ DNA replication²⁰⁰⁶

Cellular component: nucleus^{2002, 2005, 2006, 2009, 2013, 2015, 2016, 2017, 2018, 2020, 2024} nucleoplasm^{2006, 2009, 2018, 2020, 2022, 2023, 2024} nucleolus^{2009, 2011, 2020, 2023, 2024} cytoplasm^{2020, 2024} ribonucleoprotein complex^{2017, 2024} condensed chromosome^{2006, 2011, 2014, 2016, 2024} DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex^{2006, 2009, 2024} nuclear chromosome^{2006, 2009, 2024} protein-containing complex^{2014, 2024} male germ cell nucleus^{2006, 2024}
± 15 heterochromatin^{2006, 2024} cytosol^{2006, 2024} chromosome, centromeric region^{2020, 2024} centriole^{2006, 2024} chromosome^{2003, 2005, 2007, 2009, 2024} mitochondrion^{2018, 2019, 2024} synaptonemal complex^{2013, 2024} DNA replication termination region^{2019, 2024} membrane²⁰²⁴ euchromatin^{2015, 2024} chromosome, centromeric core domain^{2015, 2024} chromatin^{2017, 2024} spindle²⁰²⁴ kinetoplast²⁰¹⁷ cytoskeleton²⁰²⁴