Collated Gene Ontology terms

Biological process: ATP-dependent NAD(P)H-hydrate dehydratase activity(2013, 2014, 2015, 2019, 2021, 2024, 2025) nucleotide binding(2025) lyase activity(2025) hydro-lyase activity(2025) ATP binding(2025) ADP-dependent NAD(P)H-hydrate dehydratase activity(2011, 2016, 2019, 2025) NAD(P)HX epimerase activity(2011, 2016, 2019, 2025) catalytic activity(2025) metal ion binding(2025) isomerase activity(2025)
kinase activity2025

Molecular function: metabolite repair2018, 2024, 2025 nicotinamide nucleotide metabolic process2013, 2017, 2025 nicotinate metabolic process2025 NADP+ metabolic process2014 NAD+ metabolic process2025

Cellular component: mitochondrion2009, 2014, 2024, 2025 cytosol2009, 2014, 2024, 2025 cytoplasm2018, 2025 chloroplast2014, 2018, 2025 endoplasmic reticulum2015, 2024 mitochondrial matrix2015 kinetoplast2025

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 4/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 15/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 4/4 
Harosa: 3/4 
Hacrobia: 0/0 
Plants: 39/39 
Archea: 8/8 
Bacteria: 30/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
NNRD_ARATH
TAIR»
3.4
At5g19150 ATP-dependent (S)-NAD(P)H-hydrate dehydratase (EC
4.2.1.93) (ATP-dependent NAD(P)HX dehydratase)		 Arabidopsis thaliana
TI:3702 None
 
NNR_ECOLI
EnsemblBacteria»
3.9
nnr Bifunctional NAD(P)H-hydrate repair enzyme Nnr (Nicotinamide nucleotide repair protein) [Includes: ADP-dependent (S)-NAD(P)H-hydrate
dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]		 Escherichia coli
TI:562 None
 
NNRD_MOUSE
AG»
2.0
Naxd ATP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.93) (ATP-dependent NAD(P)HX
dehydratase) (Carbohydrate kinase domain-containing protein) (NAD(P)HX dehydratase)		 Mus musculus
TI:10090 None
 
NNRD_RAT
RGD»
3.1
Naxd ATP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.93) (ATP-dependent NAD(P)HX
dehydratase) (Carbohydrate kinase domain-containing protein) (NAD(P)HX dehydratase)		 Rattus norvegicus
TI:10116 None
   
NNRD_HUMAN
Ensembl»
3.6
NAXD ATP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.93) (ATP-dependent NAD(P)HX
dehydratase) (Carbohydrate kinase domain-containing protein) (NAD(P)HX dehydratase)		 Homo sapiens
TI:9606 None
 
NNRD_DROME
FlyBase»
2.0
Naxd ATP-dependent (S)-NAD(P)H-hydrate dehydratase (EC
4.2.1.93) (ATP-dependent NAD(P)HX dehydratase)		 Drosophila melanogaster
TI:7227 None
 
NNRD_YEAST
SGD»
2.6
NNR2 ATP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.93) (ATP-dependent
NAD(P)HX dehydratase) (Nicotinamide nucleotide repair protein 2)		 Saccharomyces cerevisiae
TI:4932 None
 
NNRD_SCHPO
PomBase»
1.5
SPCC61.03 ATP-dependent (S)-NAD(P)H-hydrate dehydratase (EC
4.2.1.93) (ATP-dependent NAD(P)HX dehydratase)		 Schizosaccharomyces pombe
TI:4896 None
 
A0A8V0YHG3_CHICK
Ensembl»
1.0
NAXD ATP-dependent (S)-NAD(P)H-hydrate dehydratase (EC
4.2.1.93) (ATP-dependent NAD(P)HX dehydratase)		 Gallus gallus
TI:9031 None
   
NNRD_CAEEL
WormBase»
1.0
R107.2 ATP-dependent (S)-NAD(P)H-hydrate dehydratase (EC
4.2.1.93) (ATP-dependent NAD(P)HX dehydratase)		 Caenorhabditis elegans
TI:6239 None
 
NNRD_DANRE
ZFIN»
1.0
naxd ATP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.93)
(ATP-dependent NAD(P)HX dehydratase) (NAD(P)HX dehydratase)		 Danio rerio
TI:7955 None
 
NNRD_DICDI
dictyBase»
1.0
DDB_G0290799 ATP-dependent (S)-NAD(P)H-hydrate dehydratase (EC
4.2.1.93) (ATP-dependent NAD(P)HX dehydratase)		 Dictyostelium discoideum
TI:44689 None